Results 201 to 210 of about 41,306 (245)

Activation of TOR signaling by diverse nitrogen signals in plants

Developmental Cell, 2021
Growth control in eukaryotes depends on the TOR kinase, which integrates energy and nutrient signals. In this issue of Developmental Cell, Liu et al. demonstrate that, in plants, inorganic nitrogen and amino acids activate TOR via the GTPase ROP2 to promote cell proliferation and leaf growth in the shoot.
Frej, Tulin, Zhenzhen, Zhang, Zhi-Yong, Wang   +2 more
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Amino Acid Signaling in TOR Activation

Annual Review of Biochemistry, 2011
The target of rapamycin (TOR) is a central cell growth regulator conserved from yeast to mammals. Uncontrolled TOR activation is commonly observed in human cancers. TOR forms two distinct structural and functional complexes, TORC1 and TORC2. TORC1 promotes cell growth and cell size by stimulating protein synthesis.
Joungmok, Kim, Kun-Liang, Guan
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Mitochondrial signaling, TOR, and life span

Biological Chemistry, 2006
Growing evidence supports the concept that mitochondrial metabolism and reactive oxygen species (ROS) play a major role in aging and determination of an organism's life span. Cellular signaling pathways regulating mitochondrial activity, and hence the generation of ROS and retrograde signaling events originating in mitochondria, have recently moved ...
Stefan M, Schieke, Toren, Finkel
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Complexity of the TOR signaling network

Trends in Cell Biology, 2006
The target of rapamycin (TOR) is a serine/threonine kinase of the phosphatidylinositol kinase-related kinase family and is highly conserved from yeast to mammals. TOR functions as a central regulator of cell growth and is itself regulated by a wide range of signals, including growth factors, nutrients and stress conditions. Recent studies in eukaryotic
Ken, Inoki, Kun-Liang, Guan
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TOR signaling in the green picoalga Ostreococcus tauri

Plant Science, 2022
Target of rapamycin (TOR) is a master regulator that controls growth and metabolism by integrating external and internal signals. Although there was a great progress in the study of TOR in plants and in the model alga Chlamydomonas, scarce data are available in other green algae.
Gonzalo, Caló, María Agustina, De Marco, Graciela Lidia, Salerno, Giselle María Astrid, Martínez-Noël   +3 more
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TOR Signals Alter Chromatin

Science's STKE, 2003
The signaling pathway controlled by the kinase TOR (target of rapamycin) governs cell growth in response to nutrient availability. It accomplishes this in part by inducing the expression of genes encoding ribosomal proteins (RP genes). Rohde and Cardenas report that TOR signaling maintains the presence of a histone acetylase called Esa1 at RP gene ...
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A Tour of TOR Complex Signaling in Plants

Trends in Biochemical Sciences, 2021
To identify the appropriate times for growth and development, organisms must sense and process information about the availability of nutrients, energy status, and environmental cues. For sessile eukaryotes such as plants, integrating such information can be critical in life or death decisions.
Graham M, Burkart, Federica, Brandizzi
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TOR signalling in bugs, brain and brawn

Nature Reviews Molecular Cell Biology, 2003
TOR--a highly conserved atypical protein kinase and the 'target of rapamycin', an immunosuppressant and anti-cancer drug--controls cell growth. TOR controls the growth of proliferating yeast, fly and mammalian cells in response to nutrients. Recent findings, however, indicate that TOR also controls the growth of non-proliferating cells, such as neurons
Jacinto, E., Hall, M. N.
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Phosphatase Targets in TOR Signaling

2007
Cells undergo growth or increase in mass in the presence of nutrients. A key signaling molecule that responds to the presence of nutrients is the target of rapamycin (TOR). TOR is a highly conserved protein kinase and is the target of the growth inhibitor rapamycin.
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TOR signalling and control of cell growth

Current Opinion in Cell Biology, 1997
TOR, phosphatidylinositol 3-kinase, p70s6k, and 4E-BP1 have recently emerged as components of a major signalling pathway that is dedicated to protein translation and thus to cell growth. This pathway appears to be conserved, at least in part, in yeast, slime molds, plants, flies, and mammals.
Thomas, G., Hall, M. N.
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