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Evolution of the TSC1/TSC2-TOR Signaling Pathway
Science Signaling, 2010The TSC1/TSC2-TOR signaling pathway evolved from a primitive signaling pathway linking adenosine monophosphate abundance to cell growth.
Jaco, Serfontein +3 more
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8 Tor-signaling and Tor-interacting proteins in yeast
2004The Tor (target of rapamycin) signaling pathway is an important mechanism used by eukaryotic cells to regulate their growth in response to nutrient-related environmental cues. Recent studies have revealed that the two Tor kinases in S. cerevisiae, Tor1p and Tor2p, regulate gene expression at several levels, including transcription, translation ...
Ted Powers +4 more
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2007
Plant development is strikingly plastic. Totipotent cell lines called meristems give rise to all post-embryonic organs—leaves, roots, flowers, for example—throughout the life of the plant. Unlike most multicellular eukaryotes, plants can change their final body plans dramatically in response to environmental and nutrient cues.
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Plant development is strikingly plastic. Totipotent cell lines called meristems give rise to all post-embryonic organs—leaves, roots, flowers, for example—throughout the life of the plant. Unlike most multicellular eukaryotes, plants can change their final body plans dramatically in response to environmental and nutrient cues.
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2010
Publisher Summary This chapter discusses target of rapamycin (TOR) signaling and aging. TOR is emerging as a key modulator of life span in multiple organisms, suggesting a conserved longevity role also in humans. TOR is a strong candidate regulator of, at least in part, the beneficial effects of dietary restriction.
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Publisher Summary This chapter discusses target of rapamycin (TOR) signaling and aging. TOR is emerging as a key modulator of life span in multiple organisms, suggesting a conserved longevity role also in humans. TOR is a strong candidate regulator of, at least in part, the beneficial effects of dietary restriction.
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The TOR Complex and Signaling Pathway in Plants
2010I. Abstract The mechanisms of plant growth and development are specific and have been shaped by their evolution as immobile, autotrophic and multicellular organisms. Indeed, plant growth is highly plastic, relatively undetermined, and strongly influenced by external conditions. Signaling pathways must therefore constantly link environmental inputs to
Moreau, Manon +5 more
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Genetic Analysis of TOR Signaling in Drosophila
2004Over a 4-day period of development, Drosophila larvae undergo a roughly 1,000-fold increase in mass. This impressive growth requires a continuous source of dietary protein; in the absence of amino acids, growth is arrested and various larval tissues display characteristic cell-cycle, metabolic, and structural changes. Mutations in the Drosophila target
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2010
Publisher Summary This chapter discusses the target of rapamycin (TOR) signaling and cell death. The evolutionarily conserved serine/threonine protein kinase, TOR, acts as a central effector of cell growth by controlling diverse metabolic processes, including translation initiation, ribosome biosynthesis, lipid synthesis, endocytosis, nutrient uptake,
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Publisher Summary This chapter discusses the target of rapamycin (TOR) signaling and cell death. The evolutionarily conserved serine/threonine protein kinase, TOR, acts as a central effector of cell growth by controlling diverse metabolic processes, including translation initiation, ribosome biosynthesis, lipid synthesis, endocytosis, nutrient uptake,
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TOR Signaling and Cell Growth Control
2005The mammalian target of rapamycin (mTOR) occupies a central position in a signaling network that regulates cell growth in response to growth factors and nutrients. Cell growth is an integral part of biological processes such as proliferation, differentiation and development.
Lisa M. Ballou, Richard Z. Lin
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Yeast TOR Signaling: A Mechanism for Metabolic Regulation
2004Understanding how cell growth is regulated in response to environmental signals remains a challenging biological problem. Recent studies indicate the TOR (target of rapamycin) kinase acts within an intracellular regulatory network used by eukaryotic cells to regulate their growth according to nutrient availability.
T, Powers +3 more
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FEBS Letters
The Target of Rapamycin (TOR) is a highly conserved protein kinase that regulates cell growth and metabolism through two distinct complexes, TORC1 and TORC2. Each complex regulates different downstream targets; however, both are activated and regulated on lipid membranes.
Robbie Loewith, Lucas Tafur
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The Target of Rapamycin (TOR) is a highly conserved protein kinase that regulates cell growth and metabolism through two distinct complexes, TORC1 and TORC2. Each complex regulates different downstream targets; however, both are activated and regulated on lipid membranes.
Robbie Loewith, Lucas Tafur
openaire +1 more source