Results 31 to 40 of about 41,306 (245)
TIF-IA-dependent regulation of ribosome synthesis in drosophila muscle is required to maintain systemic insulin signaling and larval growth. [PDF]
PLoS Genetics, 2014 The conserved TOR kinase signaling network links nutrient availability to cell, tissue and body growth in animals. One important growth-regulatory target of TOR signaling is ribosome biogenesis.
Abhishek Ghosh +2 more
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Rheb-TOR signaling promotes protein synthesis, but not glucose or amino acid import, in
BMC Biology, 2007 Background The Ras-related GTPase, Rheb, regulates the growth of animal cells. Genetic and biochemical tests place Rheb upstream of the target of rapamycin (TOR) protein kinase, and downstream of the tuberous sclerosis complex (TSC1/TSC2) and the insulin-
de la Cruz Aida +3 more
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Loss of wobble uridine modification in tRNA anticodons interferes with TOR pathway signaling
Microbial Cell, 2014 Previous work in yeast has suggested that modification of tRNAs, in particular uridine bases in the anticodon wobble position (U34), is linked to TOR (target of rapamycin) signaling.
Viktor Scheidt +4 more
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Hsf1 activation inhibits rapamycin resistance and TOR signaling in yeast revealed by combined proteomic and genetic analysis. [PDF]
PLoS ONE, 2008 TOR kinases integrate environmental and nutritional signals to regulate cell growth in eukaryotic organisms. Here, we describe results from a study combining quantitative proteomics and comparative expression analysis in the budding yeast, S. cerevisiae,
Sricharan Bandhakavi +5 more
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Frontiers in Microbiology, 2021 Phytophthora infestans, one of most famous pathogenic oomycetes, triggered the Great Irish Famine from 1845 to 1852. The target of rapamycin (TOR) is well known as a key gene in eukaryotes that controls cell growth, survival and development.
Shumin Zhang +8 more
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TOR signaling regulates microtubule structure and function [PDF]
Current Biology, 2000 The functional diversity and structural heterogeneity of microtubules are largely determined by microtubule-associated proteins (MAPs) [1] [2]. Bik1p (bilateral karyogamy defect protein) is one of the MAPs required for microtubule assembly, stability and function in cell processes such as karyogamy and nuclear migration and positioning in the yeast ...
Choi, Jae H. +5 more
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Parasites & Vectors, 2022 Background Mosquito-borne diseases threaten human health, but mosquito control faces various challenges, such as resistance to chemical insecticides. Thus, there is an urgent need for more effective and environment-friendly control agents.
Jing Wang +6 more
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TOR as a Regulatory Target in Rhipicephalus microplus Embryogenesis
Frontiers in Physiology, 2019 Embryogenesis is a metabolically intensive process carried out under tightly controlled conditions. The insulin signaling pathway regulates glucose homeostasis and is essential for reproduction in metazoan model species.
Camila Waltero +9 more
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Plant Autophagy: An Intricate Process Controlled by Various Signaling Pathways
Frontiers in Plant Science, 2021 Autophagy is a ubiquitous process used widely across plant cells to degrade cellular material and is an important regulator of plant growth and various environmental stress responses in plants.
Pingping Wang +6 more
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Mammalian TOR signaling to the AGC kinases [PDF]
Critical Reviews in Biochemistry and Molecular Biology, 2011 The mechanistic (or mammalian) target of rapamycin (mTOR), an evolutionarily conserved protein kinase, orchestrates cellular responses to growth, metabolic and stress signals. mTOR processes various extracellular and intracellular inputs as part of two mTOR protein complexes, mTORC1 or mTORC2.
Bing, Su, Estela, Jacinto
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