Results 61 to 70 of about 41,306 (245)

Targeting of the AKT/m-TOR Pathway: Biomarkers of Resistance to Cancer Therapy——
AKT/m-TOR Pathway and Resistance to Cancer Therapy

Chinese Journal of Lung Cancer, 2018
Resistance to cancer therapy continues to be a major limitation for the successful treatment of cancer. There are many published studies on therapy resistance in breast and prostate cancers; however, there are currently no data on molecular markers ...
Liudmila V SPIRINA, Irina V KONDAKOVA, Natalia V TARASENKO, Elena M SLONIMSKAYA, Evgeny A USYNIN, Alexey K GORBUNOV, Zahar A YURMAZOV, Svetlana Yu CHIGEVSKAYA   +7 more
doaj   +1 more source

RAG GTPases in nutrient-mediated TOR signaling pathway [PDF]

Cell Cycle, 2009
Amino acids are key nutrients for protein synthesis and many metabolic processes. There is compelling evidence that amino acids themselves regulate protein synthesis, degradation and cell growth. Mammalian target of rapamycin complex 1 (mTORC1) plays a central role in cellular growth regulation.
Eunjung, Kim, Kun-Liang, Guan
openaire   +2 more sources

Eco‐Friendly Synthesis of Cobalt Phthalocyanine for High‐Efficiency CO2${\rm CO}_{2}$ Electroreduction

Chemistry – A European Journal, EarlyView.
A sustainable synthesis of cobalt phthalocyanine (CoPc) using low‐impact solvents yields high‐performance electrocatalysts with reduced waste (E‐factor 18.6). When integrated into gas diffusion electrodes, CoPc achieves up to 12% Faradays efficiency for CO2‐to‐methanol and 65% CO2‐to‐CO conversion, aligning with state‐of‐the‐art materials and enabling ...
Gloria Zanotti, Federica Palmeri, Venanzio Raglione, Abdolhamid Khodadadi, Camille Tabaries, Jerome Capitolis, Mathieu Prevot, Laurent Piccolo, Mahmoud Zendehdel, Roberto Flammini, Giorgio Contini   +10 more
wiley   +1 more source

Nitrogen starvation leads to TOR kinase-mediated downregulation of fatty acid synthesis in the algae Chlorella sorokiniana and Chlamydomonas reinhardtii

BMC Plant Biology
Background When subject to stress conditions such as nutrient limitation microalgae accumulate triacylglycerol (TAG). Fatty acid, a substrate for TAG synthesis is derived from de novo synthesis or by membrane remodeling.
Jithesh Vijayan, Sophie Alvarez, Michael J. Naldrett, Wyatt Morse, Amanda Maliva, Nishikant Wase, Wayne R. Riekhof   +6 more
doaj   +1 more source

Cardiac remodelling in the era of the recommended four pillars heart failure medical therapy

ESC Heart Failure, Volume 12, Issue 2, Page 1029-1044, April 2025.
Abstract Cardiac remodelling is a key determinant of worse cardiovascular outcome in patients with heart failure (HF) and reduced ejection fraction (HFrEF). It affects both the left ventricle (LV) structure and function as well as the left atrium (LA) and the right ventricle (RV).
Giada Colombo, Tor Biering‐Sorensen, Joao P. Ferreira, Carlo Mario Lombardi, Andrea Bonelli, Andrea Garascia, Marco Metra, Riccardo M. Inciardi   +7 more
wiley   +1 more source

The Effects of Autophagy and PI3K/AKT/m-TOR Signaling Pathway on the Cell-Cycle Arrest of Rats Primary Sertoli Cells Induced by Zearalenone

Toxins, 2018
A high concentration of Zearalenone (ZEA) will perturb the differentiation of germ cells, and induce a death of germ cells, but the toxic mechanism and molecular mechanism remain unclear.
Bing-jie Wang, Wang-long Zheng, Nan-nan Feng, Tao Wang, Hui Zou, Jian-hong Gu, Yan Yuan, Xue-zhong Liu, Zong-ping Liu, Jian-chun Bian   +9 more
doaj   +1 more source

Digital Rights Activism in Multilevel Governance

European Policy Analysis, EarlyView.
ABSTRACT Multilevel governance (MLG) without a clear hierarchical structure can create power imbalances among various actors, particularly in settings with overlapping jurisdictions and policy areas. This dynamic is especially pronounced in Internet governance, which faces a complex interplay of domestic laws, state interdependence, and heightened ...
Alison Harcourt
wiley   +1 more source

Effectiveness of adjunctive low‐dose clobazam in adults with focal drug‐resistant epilepsy and incomplete response to cenobamate: A real‐world study

Epilepsia Open, EarlyView.
Abstract Objective Cenobamate (CNB) is a highly effective antiseizure medication (ASM) for focal drug‐resistant epilepsy (DRE); nevertheless, even with CNB treatment and optimized therapy, a substantial proportion of patients continued to experience seizures.
Ilaria Ciullo, Alfredo D'Aniello, Chiara Panzini, Enrico Michele Salamone, Pier Paolo Quarato, Liliana Graciela Grammaldo, Maddalena Dal Pozzo, Damiano Abeni, Giancarlo Di Gennaro   +8 more
wiley   +1 more source

Ataxia-Telangiectasia Mutated Kinase in the Control of Oxidative Stress, Mitochondria, and Autophagy in Cancer: A Maestro With a Large Orchestra

Frontiers in Oncology, 2018
Ataxia-telangiectasia mutated kinase (ATM) plays a central role in the DNA damage response (DDR) and mutations in its gene lead to the development of a rare autosomic genetic disorder, ataxia telangiectasia (A-T) characterized by neurodegeneration ...
Venturina Stagni, Venturina Stagni, Claudia Cirotti, Claudia Cirotti, Daniela Barilà, Daniela Barilà   +5 more
doaj   +1 more source

A Multivariate Mixed‐Effects Regression Framework for Ground Motion Modeling: Integrating Parametric and Machine Learning Approaches

Earthquake Engineering &Structural Dynamics, EarlyView.
ABSTRACT Multivariate ground motion models (GMMs) that capture the correlation between different intensity measures (IMs) are essential for seismic risk assessment. Conventional GMMs are often developed using a two‐stage approach, where separate univariate models with predefined functional forms are fitted first, and correlation is addressed in a ...
Sayed Mohammad Sajad Hussaini, Shaghayegh Karimzadeh, Paulo B. Lourenço   +2 more
wiley   +1 more source