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The suppression of torulene and torularhodin treatment on the growth of PC-3 xenograft prostate tumors

Biochemical and Biophysical Research Communications, 2016
Torulene and torularhodin are two of the principal carotenoids in Sporidiobolus pararoseus and have a similar structure to that of lycopene. The present study was to elucidate the anti-cancer activity of torulene and torularhodin in vivo with lycopene as a control. Nude mice were orally supplemented every day with a low or high dose [9 or 18 mg/kg body
Yahui Guo, Chang Liu, Weiguo Zhang
exaly   +3 more sources

Increased torulene accumulation in red yeast Sporidiobolus pararoseus NGR as stress response to high salt conditions

Food Chemistry, 2017
Carotenoids represent a class of molecules valuable for food, chemical and pharmaceutical industries. As a microbial carotenoid, torulene possesses potential health-promoting effects in human. However, few studies have been conducted to investigate optimal condition for its large-scale commercial production to date.
Hongtao Zou, Bingxue Li, Chunji Li
exaly   +3 more sources

Investigation of factors influencing production of the monocyclic carotenoid torulene in metabolically engineered Escherichia coli

Applied Microbiology and Biotechnology, 2004
Factors influencing production of the monocyclic carotenoid torulene in recombinant Escherichia coli were investigated by modulating enzyme expression level, culture conditions, and engineering of the isoprenoid precursor pathway. The gene dosage of in vitro evolved lycopene cyclase crtY2 significantly changed the carotenoid profile.
Pyung Cheon Lee   +2 more
exaly   +3 more sources

Identification of the gene responsible for torulene cleavage in the Neurospora carotenoid pathway

Molecular Genetics and Genomics, 2007
Torulene, a C(40) carotene, is the precursor of the end product of the Neurospora carotenoid pathway, the C(35) xanthophyll neurosporaxanthin. Torulene is synthesized by the enzymes AL-2 and AL-1 from the precursor geranylgeranyl diphosphate and then cleaved by an unknown enzyme into the C(35) apocarotenoid.
Javier Avalos   +2 more
exaly   +3 more sources

Production of Torularhodin, Torulene, and β-Carotene by Rhodotorula Yeasts

Methods in Molecular Biology, 2012
Yeasts of the genera Rhodotorula are able to synthesize different pigments of high economic value like β-carotene, torulene, and torularhodin, and therefore represent a biotechnologically interesting group of yeasts. However, the low production rate of pigment in these microorganisms limits its industrial application.
Diego Libkind Frati   +2 more
exaly   +3 more sources

Tentative Identification of Torulene Cis/trans Geometrical Isomers Isolated from Sporidiobolus pararoseus by High-Performance Liquid Chromatography-Diode Array Detection-Mass Spectrometry and Preparation by Column Chromatography

open access: yesAnalytical Sciences, 2013
The major carotenoids (β-carotene, γ-carotene, torulene, and torularhodin) were determined by high-performance liquid chromatography, with torulene present in the largest amount (167.0 μg/g), followed by torularhodin (113.4 μg/g), β-carotene (52.1 μg/g) and γ-carotene (15.4 μg/g).
Chao Du, Chang Liu, Weiguo Zhang
exaly   +4 more sources

Transcriptomic and Metabolomic Analyses Provide Insights into the Enhancement of Torulene and Torularhodin Production in Rhodotorula glutinis ZHK under Moderate Salt Conditions

Journal of Agricultural and Food Chemistry, 2021
Carotenoids are a group of tetraterpene pigments widely used in the food, pharmaceutical, and cosmetic industries. Torulene, torularhodin, and β-carotene, three principal carotenoids synthesized by Rhodotorula glutinis ZHK, possess strong health-promoting properties such as antioxidant, provitamin A, and antitumor.
Chunji Li   +6 more
openaire   +2 more sources

Anti-cancer effects of torulene, isolated from Sporidiobolus pararoseus, on human prostate cancer LNCaP and PC-3 cells via a mitochondrial signal pathway and the down-regulation of AR expression

open access: yesRSC Advances, 2017
Torulene, inhibit LNCaP and PC-3 cells growth through Bcl-2/Bax mediated apoptosis and AR down-regulation.
Yuliang Cheng, Yahui Guo, Chang Liu
exaly   +3 more sources

Torulene and torularhodin, protects human prostate stromal cells from hydrogen peroxide-induced oxidative stress damage through the regulation of Bcl-2/Bax mediated apoptosis

Free Radical Research, 2017
The current study was designed to elucidate the cytoprotective effects and possible mechanisms of torulene and torularhodin on hydrogen peroxide (H2O2)-induced oxidative stress damage in human prostate stromal cells (WPMY-1). After treated with H2O2, a notable decrease was appeared in cell viability, yet the decrease was attenuated when cells were ...
Yuliang Cheng, Yahui Guo, Chang Liu
exaly   +3 more sources

Reactions of OOH Radical with β-Carotene, Lycopene, and Torulene: Hydrogen Atom Transfer and Adduct Formation Mechanisms

Journal of Physical Chemistry B, 2009
The relative free radical scavenging activity of beta-carotene, lycopene, and torulene toward OOH radicals has been studied using density functional theory. Hydrogen atom transfer (HAT) and radical adduct formation (RAF) mechanisms have been considered.
Annia Galano, Francisco-Márquez M
exaly   +3 more sources

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