Results 91 to 100 of about 2,710,536 (294)

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Comprehensive Second-Order Adjoint Sensitivity Analysis Methodology (2nd-ASAM) Applied to a Subcritical Experimental Reactor Physics Benchmark: III. Effects of Imprecisely Known Microscopic Fission Cross Sections and Average Number of Neutrons per Fission

Energies, 2019
The Second-Order Adjoint Sensitivity Analysis Methodology (2nd-ASAM) is applied to compute the first-order and second-order sensitivities of the leakage response of a polyethylene-reflected plutonium (PERP) experimental system with respect to the ...
D. G. Cacuci, R. Fang, J. A. Favorite, M. C. Badea, F. Di Rocco   +4 more
doaj   +1 more source

Hadronic total cross sections at high energy and the QCD spectrum [PDF]

, 2014
We show how to obtain the leading energy dependence of hadronic total cross sections, in the framework of the nonperturbative approach to soft high-energy scattering based on Wilson-loop correlation functions, if certain nontrivial analyticity ...
Giordano, Matteo, Meggiolaro, Enrico
core   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Next-to-Leading Order QCD Corrections to the Direct Top Quark Production via Model-independent FCNC Couplings at Hadron Colliders

, 2005
We calculated the next-to-leading order (NLO) QCD corrections to the cross sections for direct top quark productions induced by model--independent flavour changing neutral current couplings at hadron colliders.
Chong Sheng Li, J. A. Aguilar-Saavedra, Jian Jun Liu, Li Gang Jin, Li Lin Yang   +4 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Next-to-leading order QCD predictions for $A^0Z^0$ associated production at the CERN Large Hadron Collider

, 2005
We present the calculations of the complete next-to-leading order (NLO) QCD corrections (including supersymmetric QCD) to the inclusive total cross sections of the associated production processes $pp\to A^0Z^0+X$ in the Minimal Supersymmetric Standard ...
A. Denner, A. Djouadi, C.-P. Yuan, Chong Sheng Li, F. Gianotti, J. C. Collins, Jian Jun Liu, K. I. Aoki, Li Gang Jin, M. Dittmar, Qiang Li, W. J. Marciano, Y. Okada   +12 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

On a relation between production processes and total cross sections

, 2013
Perturbative QCD is the appropriate tool to describe many important properties of the inclusive observables measured at electron-proton (or ion) colliders, such as the energy dependence of the total cross sections in well-chosen kinematical regions. This
Munier, Stephane
core   +1 more source