Results 101 to 110 of about 2,710,536 (294)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

P-P Total Cross Sections at VHE from Accelerator Data

, 2004
Comparison of P-P total cross-sections estimations at very high energies - from accelerators and cosmic rays - shows a disagreement amounting to more than 10 %, a discrepancy which is beyond statistical errors.
, , , A Faus-Golfe, A Gallegos-Cruz, A Sánchez-Hertz, Albrow M, Avila R F Luna E G S Menon M J, Baltrusatis R M, Basilevsky A, Caravalho P A S Martini A F Menon M J, Chatfield Ch, Cheng H, Chou T, Cramer H, Cudell J R Ezhela V Kang K Lugovsky S Tkachenko N, Cudell J R Ezhela V V Gauron P Kang K Kuyanonv Yu V Lugovsky S B Martynov E Nicolescu B Razuvaev E A Tkachenko N P (COMPETE Collaboration), Dias de Deus J, Eadie W T, Fuller W A, Glauber R J, Glauber R J, Gribov V N, J Pérez-Peraza, J Velasco, Kang K Kim S K, Lipari P, Lukaszuk L, Luna E G S Menon M J, M Alvarez-Madrigal, Martin A, Matthiae G, Mendenhall W, Menon M J, Nicolescu B Cudell J R Ezhela V V Gauron P Kang K Kuyanonv Yu V Lugovsky S B Razuvaev E A Tkachenko N P (COMPETE Collaboration), Nicolescu B Cudell J R Ezhela V V Gauron P Kang K Kuyanonv Yu V Lugovsky S B Tkachenko N P (COMPETE Collaboration), Perez-Peraza J Gallegos-Cruz A Velasco J Sanchez-Hertz A Faus-Golfe A Alvarez-Madrigal M, Pryke C L, Schubert K R, Velasco J Perez-Peraza J Gallegos-Cruz A Alvarez-Madrigal M Faus-Golfe A Sanchez-Hertz A   +39 more
core   +2 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Comparison of Cross-Sections of Different Femoral Components for Revision Total Knee Replacement

Journal of Orthopaedic Surgery, 2012
Purpose. To compare the inner contour of the femoral component of 10 total knee replacement (TKR) designs for possible exchange in use. Methods. Inner contours of the femoral components of 10 cemented, cruciate-retaining TKR designs (e.motion, Genesis ...
Carmen Zietz, Philipp Bergschmidt, Andreas Fritsche, Daniel Kluess, Wolfram Mittelmeier, Rainer Bader   +5 more
doaj   +1 more source

Investigation of complete and incomplete fusion in $^{7}$Li+$^{124}$Sn reaction around Coulomb barrier energies

, 2018
The complete and incomplete fusion cross sections for $^{7}$Li+$^{124}$Sn reaction were measured using online and offline characteristic $\gamma$-ray detection techniques. The complete fusion (CF) cross sections at energies above the Coulomb barrier were
Jha, V., Kanagalekar, Bhushan, Mahata, K., Nag, T. N., Palit, R., Pandit, S. K., Parkar, V. V., Ramachandran, K., Rath, P. K., Santra, S., Sharma, Sushil K., Shrivastava, A., Trivedi, T., Upadhyaya, S.   +13 more
core   +1 more source

The total charm cross section [PDF]

The European Physical Journal Special Topics, 2008
We assess the theoretical uncertainties on the total charm cross section. We discuss the importance of the quark mass, the scale choice and the parton densities on the estimate of the uncertainty. We conclude that due to the small charm quark mass, which amplifies the effect of the other parameters in the calculation, the uncertainty on the total charm
openaire   +2 more sources

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Reactions with light exotic nuclei

EPJ Web of Conferences, 2014
Experimental cross sections for the 6He+120Sn are analysed. Elastic scattering angular distributions and alpha particle production cross sections have been measured and are compared with the total reaction cross sections.
Lichtenthäler R., de Faria P. N., Pires K. C. C., Moro A. M., Lépine-Szily A., Guimarães V., Mendes D. R., Arazi A., Assunção M., Barioni M., Morcelle V., Morais M.C., Camargo O., Alcantara Nuñez J., Rodríguez-Gallardo M.   +14 more
doaj   +1 more source