Results 141 to 150 of about 6,662,662 (243)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
The $k$-Total Bondage Number of a Graph
Theory and Applications of GraphsLet \(G=(V,E)\) be a connected, finite undirected graph. A set \(S \subseteq V\) is said to be a total dominating set of \(G\) if every vertex in \(V\) is adjacent to some vertex in \(S\).
Jean-Pierre Appel +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
On the domination number and the total domination number of Fibonacci cubes
Ars Mathematica Contemporanea, 2019 Summary: Fibonacci cubes are special subgraphs of the hypercube graphs. Their domination numbers and total domination numbers are obtained for some small dimensions by integer linear programming. For larger dimensions upper and lower bounds on these numbers are given.
openaire +7 more sources
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
UPPER TOTAL DOMINATION VERSUS UPPER PAIRED-DOMINATION
, 2007 Let G be a graph with no isolated vertices. A set S of vertices in G is a total dominating set of G if every vertex of G is adjacent to some vertex in S, while a paired-dominating set of G is a dominating set of vertices whose induced subgraph has a ...
Mccoy, John +6 more
core
Signed total domination number of a graph [PDF]
, 2001 summary:The signed total domination number of a graph is a certain variant of the domination number. If $v$ is a vertex of a graph $G$, then $N(v)$ is its oper neighbourhood, i.e. the set of all vertices adjacent to $v$ in $G$.
Zelinka, Bohdan
core
Indicated total domination game [PDF]
A vertex $u$ in a graph $G$ totally dominates a vertex $v$ if $u$ is adjacent to $v$ in $G$. A total dominating set of $G$ is a set $S$ of vertices of $G$ such that every vertex of $G$ is totally dominated by a vertex in $S$.
Rall, Douglas F., Henning, Michael A.
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source