Results 111 to 120 of about 1,521,521 (318)

Total domination numbers of cartesian products

open access: yesMathematical communications, 2004
Let $G\Box H$ denote the cartesian product of graphs G and H. Here we determine the total domination numbers of $P_5\Box P_n$ and $P_6\Box P_n$.
openaire   +4 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Total outer-connected domination number of middle graphs [PDF]

open access: green, 2023
Farshad Kazemnejad   +3 more
openalex   +1 more source

Total domination number of grid graphs

open access: yesDiscrete Applied Mathematics, 2002
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

On the total domatic number of regular graphs [PDF]

open access: yesTransactions on Combinatorics, 2012
A set S of vertices of a graph G = (V;E) without isolated vertex is a total dominating set if every vertex of V (G) is adjacent to some vertex in S.
H. Aram   +2 more
doaj  

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Lower bounds on the signed (total) $k$-domination number depending on the clique number

open access: yesCommunications in Combinatorics and Optimization, 2018
Let $G$ be a graph with vertex set $V(G)$‎. ‎For any integer $k\ge 1$‎, ‎a signed (total) $k$-dominating function‎ ‎is a function $f‎: ‎V(G) \rightarrow‎ \{ -1, ‎1\}$ satisfying $\sum_{x\in N[v]}f(x)\ge k$ ($\sum_{x\in N(v)}f(x)\ge k$)‎ ‎for every $v ...
L‎. ‎Volkmann
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

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