Results 221 to 230 of about 5,447,906 (320)

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

High-throughput sheathless focusing and sorting of flexible microalgae in spiral-coupled contraction-expansion channels. [PDF]

Microsyst Nanoeng
Zhou T, Wu Z, Wang L, Wan S, Qian G, Yan H, Deng Y, Shi L.   +7 more
europepmc   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

A stochastic approach to k-nearest neighbors search using a fixed radius method. [PDF]

Comput Stat
Cano Urrego B, Alsup A, Thompson JA, Koestler DC.   +3 more
europepmc   +1 more source

Detection of internal defects in concrete by ultrasonic total focusing imaging using the delay-multiply-and-sum method

Yiqiong Chen, Lifan Rong, Ying Song, Xingyu Yang   +3 more
openalex   +1 more source

The sobol sensitivity analysis of the pressure, stresses, and displacement arising from poroelastic modelling of hard mechanical systems. [PDF]

Sci Rep
Asghari H, Miller L, Penta R, Melnikov A, Spitas C, Merodio J.   +5 more
europepmc   +1 more source

A Multi-Objective Optimization Method for Cylindrical Surface Ultrasonic Array Parameters Based on BPNN and NSGA-II. [PDF]

Sensors (Basel)
Zeng X, Cao X, Zhao J, Dai Y, Li C, Chen H.   +5 more
europepmc   +1 more source

A Neural Style Transfer Data Augmentation Strategy as Applied to Total Focusing Method Images: A Classification Task Perspective

Roberto Miorelli, Léonard Le Jeune, S. Mahaut, Souad Bannouf   +3 more
openalex   +2 more sources