Results 1 to 10 of about 133,635 (182)

Total neoadjuvant therapy for rectal cancer: evidence and challenge [PDF]

Annals of Coloproctology, 2023
Recent advances in the management of rectal cancer have dramatically changed the clinical practice of colorectal surgeons because the main focus of rectal cancer treatment has changed from sphincter-saving to an organ-preserving strategies. Modifying the
Suk-Hwan Lee
doaj   +3 more sources

Total neoadjuvant therapy for locally advanced rectal cancer. [PDF]

Cochrane Database Syst Rev
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the effectiveness and safety of total neoadjuvant therapy versus standard therapy in individuals with locally advanced rectal cancer.
Mueller S, Kao YS, Kastner C, Chen PH, Hendricks A, Lee GY, Koehler F, Jhou HJ, Germer CT, Kang EY, Janka H, Ho CL, Lee CH, Wiegering A.   +13 more
europepmc   +6 more sources

Comparing outcomes following total neoadjuvant therapy and following neoadjuvant chemoradiation therapy in patients with locally advanced rectal cancer [PDF]

EClinicalMedicine, 2019
Background: There is recent interest in treating locally advanced rectal cancer (LARC) patients with total neoadjuvant therapy (TNT). However, whether TNT is associated with improved overall survival (OS) remains unknown.
Shaoyu Zhu, N. Patrik Brodin, Keara English, Nitin Ohri, Jennifer W. Chuy, Lakshmi N. Rajdev, Rahul Narang, Shalom Kalnicki, Chandan Guha, Madhur K. Garg, Rafi Kabarriti   +10 more
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Quality of life following total neoadjuvant therapy for rectal cancer [PDF]

Journal of Cancer Research and Clinical Oncology
Purpose This study aimed to assess the health-related quality of life (HRQoL) in patients with locally advanced rectal cancer (LARC) undergoing total neoadjuvant therapy (TNT), comparing outcomes with the German general population and colorectal cancer ...
Georg W. Wurschi, Markus Diefenhardt, Justus Kaufmann, Hai Minh Ha, Melanie Schneider, Daphne Schepers von Ohlen, Maren Schöneich, Adrianna Cieslak, Alina Depardon, Jan-Niklas Becker, Alexander Rühle, Felix Ehret, Maximilian Römer, Florian Rißner, Andreas Hinz, Klaus Pietschmann   +15 more
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Comparison of Standard Neoadjuvant Therapy and Total Neoadjuvant Therapy in Terms of Effectiveness in Patients Diagnosed with Locally Advanced Rectal Cancer [PDF]

Medicina
Background/Objectives: The study aimed to compare the treatment effectiveness of patients with locally advanced rectal cancer undergoing standard neoadjuvant therapy or total neoadjuvant therapy.
Ayberk Bayramgil, Ahmet Bilici, Ali Murat Tatlı, Seda Kahraman, Yunus Emre Altintas, Fahri Akgul, Musa Barış Aykan, Jamshid Hamdard, Sema Sezgin Göksu, Mehmet Ali Nahit Şendur, Fatih Selçukbiricik, Ömer Fatih Ölmez   +11 more
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New Pattern of Rectal Cancer Treatment: Total Neoadjuvant Therapy

Zhongliu Fangzhi Yanjiu, 2018
Total neoadjuvant therapy (TNT) transfers postoperative adjuvant chemotherapy for rectal cancer to preoperative surgery. Preoperative neoadjuvant chemotherapy followed by concurrent chemoradiotherapy is designed to improve patient compliance and long ...
SUN Peiyan, WU Gang, SUN Peichun
doaj   +2 more sources

Total Neoadjuvant Therapy Versus Conventional Neoadjuvant Therapy for Rectal Cancer: Cost Analysis in a Public Healthcare System. [PDF]

ANZ J Surg
ABSTRACTPurposeTotal neoadjuvant therapy (TNT) has become the standard of care in locally advanced rectal cancer, but its economic impact is unclear. This study compares the cost of TNT with conventional neoadjuvant therapy (CNT), consisting of either short‐course radiotherapy or long‐course chemoradiotherapy, within a universally funded public ...
Murshed I, Bedrikovetski S, Murshed I, Bunjo Z, Fitzsimmons T, Thomas M, Sammour T.   +6 more
europepmc   +3 more sources

Influence of neoadjuvant radiotherapy combined with immunotherapy on minimally invasive surgeries for rectal cancer [PDF]

Waike lilun yu shijian, 2023
The current domestic and international guidelines recommend neoadjuvant chemoradiation or total neoadjuvant therapy followed by radical surgery for mid-low locally advanced rectal cancer.
YANG Yingchi, PANG Kai, ZHANG Zhongtao
doaj   +1 more source

Neoadjuvant therapy in rectal cancer—one year follow-up results of standard versus total neoadjuvant strategies

World Journal of Surgical Oncology
Background Locally advanced rectal cancer (LARC) poses a significantly challenge in clinical management, requiring a multimodal treatment approach.
Luís Correia Gomes, Bernardo Alves Pereira, Isália Miguel, Ana Luís, Ana Pina, Cátia Pedro, Daniela Cavadas, Daniela Pereira, Joana Lemos, João Maciel, João Oliveira, José Venâncio, Madalena Santos, Manuel Limbert, Miguel Braga, Miriam Abdulrehman, Pedro Freitas, Ricardo Fonseca, Teresa Ferreira, Isadora Rosa   +19 more
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Total neoadjuvant therapy in rectal cancer: a network meta-analysis of randomized trials [PDF]

Annals of Coloproctology, 2023
Purpose To assess the efficacy of total neoadjuvant therapy (TNT) for rectal carcinoma in comparison with conventional chemoradiotherapy (CRT). Methods A systematic review was performed according to the PRISMA guidelines. A Bayesian network meta-analysis
Sergey Sychev, Aleksey Ponomarenko, Stanislav Chernyshov, Mikhail Alekseev, Zaman Mamedli, Dmitriy Kuzmichev, Andrey Polynovskiy, Evgeny Rybakov   +7 more
doaj   +1 more source