Results 131 to 140 of about 8,795,233 (257)

Adjuvant and neoadjuvant therapy with lapatinib in ErbB2-overexpressing breast cancer [PDF]

, 2008
Möbus, Volker, Minckwitz, Gunter von, Nitz, Ulrike, Janni, Wolfgang   +3 more
core   +1 more source

CD86‐Positive Mature Tertiary Lymphoid Structures Are Associated With CD8+ T‐Cell Infiltration and Favorable Clinical Outcomes in Pancreatic Ductal Adenocarcinoma

Annals of Gastroenterological Surgery, EarlyView.
CD86‐positive mature tertiary lymphoid structures were associated with increased intratumoral CD8+ T‐cell infiltration, a higher proportion of Granzyme B‐expressing CD8+ T cells in an exploratory analysis, and favorable clinical outcomes in pancreatic ductal adenocarcinoma.
Takaomi Seki, Kenichiro Araki, Takehiko Yokobori, Hayato Ikota, Norio Kubo, Takamichi Igarashi, Mariko Tsukagoshi, Norihiro Ishii, Yasuo Hosouchi, Hiroshi Saeki, Ken Shirabe   +10 more
wiley   +1 more source

Neoadjuvant Therapy and the Evolving Management of Resectable Advanced Melanoma

Melanoma has long represented a unique challenge in oncology. In its early stages, it can often be cured with surgery alone, resulting in excellent survival outcomes.
Jacopo Pigozzo, Gabriele Roccuzzo, Nikolaos Papadopoulos, Luisa Piccin, Alessandro Minisini, Paolo Fava, Michele Del Vecchio, Andrea Spagnoletti, Federico Pravisano, Carolina Cimminiello   +9 more
core   +1 more source

Long‐Term Stoma‐Free Outcomes After Diverting Stoma Closure Following Radiation‐Based Neoadjuvant Treatment for Rectal Cancer

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Aim Long‐term stoma‐free outcomes after diverting stoma closure in patients who underwent sphincter‐preserving rectal cancer surgery with double‐stapling technique (DST) reconstruction following radiation‐based neoadjuvant treatment remain unclear.
Hidetaka Ichikawa, Shimpei Matsui, Kentaro Sato, Tatsuki Noguchi, Takashi Sakamoto, Toshiki Mukai, Tomohiro Yamaguchi, Takashi Akiyoshi   +7 more
wiley   +1 more source

Potential and limitations of deep learning-based MRI in assessing complete response and the “watch and wait” strategy for rectal cancer

结直肠肛门外科
With the widespread adoption of neoadjuvant therapy and the development of combined treatment strategies such as total neoadjuvant therapy, targeted therapy, and immunotherapy, the rate of tumor complete response in patients with locally advanced rectal ...
Zhao Xinzhe, Diao Dechang
doaj   +1 more source

Laparoscopic Surgery Is Associated With Reduced Small Bowel Obstruction Risk After Colorectal Cancer Surgery: A Nationwide Cohort Study of 5458 Patients

Annals of Gastroenterological Surgery, EarlyView.
Abbreviated Abstract This nationwide retrospective cohort study of 5458 colorectal cancer surgeries across 32 Japanese institutions examined the effects of laparoscopic surgery, adhesion prevention materials (APMs), and stoma creation on the 5‐year risk of small bowel obstruction (SBO).
Takeshi Yamada, Fumihiko Fujita, Ken Eto, Kozo Kataoka, Norio Yukawa, Kiichi Sugimoto, Rai Shimoyama, Atsuko Fukazawa, Kensuke Kumamoto, Yuichi Takayama, Akira Komono, Akihisa Matsuda, Ryo Ohta, Hiromichi Sonoda, Koichi Okuya, Keisuke Ihara, Yasuyuki Yokoyama, Takuya Nishino, Yasuki Akiyama, Daisuke Ichikawa   +19 more
wiley   +1 more source

Can Chemoradiotherapy Expand Immune Checkpoint Blockade Responsiveness in Mismatch Repair‐Proficient Rectal Cancer?

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Immune checkpoint blockade (ICB) has transformed the treatment of mismatch repair‐deficient (dMMR) colorectal cancer but produces no meaningful benefit in advanced mismatch repair‐proficient (pMMR) disease. In the neoadjuvant setting, however, pathological responses have been reported in a subset of pMMR tumors, suggesting that clinical ...
Kimihiro Yamashita, Takeru Matsuda, Junko Mukohyama, Ryohei Sasaki, Yoshihiro Kakeji   +4 more
wiley   +1 more source

Minimally Invasive Versus Open Total and Distal Gastrectomy After Chemotherapy for Gastric Cancer: A Nationwide Observational Study

Annals of Gastroenterological Surgery, EarlyView.
This nationwide observational study used data from the National Clinical Database. Patients who underwent total or distal gastrectomy for gastric cancer after chemotherapy between January 2014 and December 2022 were included. Minimally invasive surgery was associated with lower incidences of overall postoperative complications of Clavien–Dindo grade ...
Nobuaki Hoshino, Shinya Hirakawa, Shiogeo Hisamori, Hisateru Tachimori, Yusuke Fujii, Koshi Kumagai, Hideki Ueno, Ken Shirabe, Kazutaka Obama   +8 more
wiley   +1 more source

The Geriatric Nutritional Risk Index Predicts Short‐ and Long‐Term Outcomes in the Oldest‐Old With Colorectal Cancer: A Multi‐Institutional Analysis of 225 Nonagenarians

Annals of Gastroenterological Surgery, EarlyView.
This multi‐institutional study evaluated the Geriatric Nutritional Risk Index (GNRI) in 225 nonagenarians undergoing surgical resection for colorectal cancer. A lower preoperative GNRI was independently associated with a longer hospital stay and poorer overall survival, even after adjustment for confounders using inverse‐probability‐of‐treatment ...
Toshiaki Toshima, Fuminori Teraishi, Satoe Takanaga, Toshiharu Mitsuhashi, Ryo Inada, Tsuyoshi Ohtani, Ryosuke Yoshida, Naoto Hori, Kaoru Shigemitsu, Sumiharu Yamamoto, Tetsushi Kubota, Yuka Okano, Tetsuji Nobuhisa, Fumitaka Taniguchi, Wataru Ishikawa, Ryohei Shoji, Tatsuo Matsuda, Tatsuo Umeoka, Toshiyoshi Fujiwara, The Setouchi Colorectal Neoplasm Registration Study Group Collaborators   +19 more
wiley   +1 more source

Dismal pathological response to neoadjuvant chemotherapy in stage III breast cancer patients in Tanzania: A retrospective review.

PLoS ONE
Response to neoadjuvant treatment in breast cancer has been associated with good oncological outcomes. In Tanzania, a majority of breast cancer patients are diagnosed at stage III; hence, they almost always require neoadjuvant therapy.
Nashivai Kivuyo, Larry Akoko, John Of God Mutajwaha, Caspar Haule, Innocent Mosha, Mungeni Misidai, Daniel Kitua, Obadia Nyongole, Ally Mwanga   +8 more
doaj   +1 more source