Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Pansharpening using total variation regularization [PDF]
, 2012 International audienceIn remote sensing, pansharpening refers to the technique that combines the complementary spectral and spatial resolution characteristics of a multispectral image and a panchromatic image, with the objective to generate a high ...
Xiyan He +7 more
core +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
A new inequality for the Riemann-Stieltjes integrals driven by irregular signals in Banach spaces
Journal of Inequalities and Applications, 2018 We prove an inequality of the Loéve-Young type for the Riemann-Stieltjes integrals driven by irregular signals attaining their values in Banach spaces, and, as a result, we derive a new theorem on the existence of the Riemann-Stieltjes integrals driven ...
Rafał M Łochowski
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Semisoft Generalized Total Variation Minimization for Image Reconstruction in Computed Tomography
IEEE Access, 2017 The generalized l1 greedy algorithm was recently proposed and shown to outperform the standard reweighted l1-minimization and l1-greedy algorithms for image reconstruction in computed tomography (CT).
Xiezhang Li +3 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Maps of several variables of finite total variation. I. Mixed differences and the total variation [PDF]
, 2010 Given two points a=(a1,…,an) and b=(b1,…,bn) from Rn with ...
Chistyakov, Vyacheslav V. +1 more
core +1 more source
Rate of convergence of Stancu beta operators for functions of bounded variation
Journal of Numerical Analysis and Approximation Theory, 2004 In this paper we study beta operators of second kind recently introduced by Prof. D. D. Stancu. We obtain an estimate on the rate of convergence for functions of bounded variation by means of the decomposition technique.
Ulrich Abel, Vijay Gupta
doaj +2 more sources
Variational Destriping in Remote Sensing Imagery: Total Variation with L1 Fidelity
Remote Sensing, 2018 This paper introduces a variational method for destriping data acquired by pushbroom-type satellite imaging systems. The model leverages sparsity in signals and is based on current research in sparse optimization and compressed sensing.
Igor Yanovsky, Konstantin Dragomiretskiy
doaj +1 more source