Results 91 to 100 of about 5,438,961 (250)
Generalized totally nonnegative matrices [PDF]
, 2002 We define a new class of generalized totally nonnegative matrices, shortly GTN-matrices, over a noncommutative ring with identity and a positive part.
Miroslav Fiedler +3 more
core +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
, 1999 An m-by-n matrix A is called totally nonnegative (resp. totally positive) if the determinant of every square submatrix (i.e., minor) of A is nonnegative (resp. positive).
Fallat, Shaun M.
core +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Infinite totally positive matrices: some open problems
How can the variation-diminishing property and the invertibility conditions of totally positive matrices be extended to infinite totally positive matrices? These questions arise in the context of sampling theory and time-frequency analysis.
Karlheinz Gröchenig
core +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta +7 more
wiley +1 more source
ANÁLISE DAS VARIÁVEIS DE UMA AMOSTRA DE CERÂMICA PAPEBA
Clio Arqueológica, 2012 Aplicando uma abordagem de análise de cerâmica arqueológica desenvolvida através de estudos etnoarqueológicos com populações indígenas brasileiras, o autor analisa uma amostra de cerâmica recolhida da superfície do Sítio Papeba, RN, envolvendo parâmetros
Tom O. Miller
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