Results 81 to 90 of about 5,438,961 (250)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
A combinatorial interpretation of the LDU-decomposition of totally positive matrices and their inverses [PDF]
, 2018 We study the combinatorial description of the LDU-decomposition of totally positive matrices. We give a description of the lower triangular L, the diagonal D, and the upper triangular U matrices of the LDU-decomposition of totally positive matrices in ...
Muhammad ElGebali +3 more
core +1 more source
Construction and validation of a risk prediction model for high altitude de-acclimatization syndrome
陆军军医大学学报Objective To construct risk models for predicting the occurrence of high altitude de-acclimatization syndrome （HADAS） in the population returning from the plateau to the plain based on different machine learning algorithms and validate the predicting ...
DING Yu +5 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
A class of totally positive P-matrices whose inverses are M-matrices [PDF]
, 2007 In this work we introduce some technical conditions to prove that a P-matrix has an inverse M-matrix.
Gassó, M., Torregrosa, Juan R.
core +1 more source
Intervals of Almost Totally Positive Matrices
, 2001 We consider the class of the totally nonnegative matrices, i.e., the matrices having all their minors nonnegative, and intervals of matrices with respect to the chequerboard partial ordering, which results from the usual entrywise partial ordering if we ...
Garloff, Jürgen
core +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Elimination techniques: from extrapolation to totally positive matrices and CAGD [PDF]
, 2000 In this survey, we will show some connections between several mathematical problems such as extrapolation, linear systems, totally positive matrices and computer-aided geometric design, with elimination techniques as the common tool to deal with all of ...
Mühlbach, G. +3 more
core +1 more source
Total Positivity of Toeplitz Matrices of Hyperlucas Sequence
, 2020 See the abstract in the attached pdf.
Rezig, Boualam, Ahmia, Moussa
openaire +3 more sources
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source