Results 61 to 70 of about 10,628 (259)

Trace compounds in the urban water cycle in the Freiberg region, Germany

open access: yesFrontiers in Water
Urban water contamination has become a pressing concern due to the surge in urbanization, industrialization, and population growth, resulting in increased pollution levels and the introduction of emerging contaminants (ECs) into the environment.
Dibyanshu, Marco Kern, Traugott Scheytt
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Totally nonnegative matrices

open access: yes, 1999
An m-by-n matrix A is called totally nonnegative (resp. totally positive) if the determinant of every square submatrix (i.e., minor) of A is nonnegative (resp. positive).
Fallat, Shaun M.
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

A probabilistic representation of totally positive matrices

open access: yes, 1986
C. Loewner (Math. Z. 63 (1955), 338–340) has shown that every non-singular totally positive matrix of finite order can be reached from the identity by forward solutions of the control equation dRdt = C(t)R, when C(t) varies in the class of Jacobi ...
Goodman, Gerald S
core   +1 more source

Investigation of metal(loid) concentrations in drinking water and urine: A biomonitoring study in Qom, central Iran

open access: yesHeliyon
The main purpose of this study was to assess metal(loid) concentrations in drinking water and urine samples from adults in Qom, Iran. Additionally, the study aimed to analyze these concentrations based on age, sex, and season, and to investigate the ...
Leila Kazemizad   +6 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

The LU-factorization of totally positive matrices

open access: yes, 1973
An n × n real matrix A is an STP (strictly totally positive) matrix if all its minors are strictly positive. An n × n real triangular matrix A is a ΔSTP matrix if all its nontrivial minors are strictly positive. It is proved that A is an STP matrix iff A
Colin W. Cryer, Cryer, Colin W.
core   +1 more source

Total Positivity of Toeplitz Matrices of Hyperlucas Sequence

open access: yes, 2020
See the abstract in the attached pdf.
Rezig, Boualam, Ahmia, Moussa
openaire   +3 more sources

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

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