Results 71 to 80 of about 5,438,961 (250)
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Trace compounds in the urban water cycle in the Freiberg region, Germany
Frontiers in WaterUrban water contamination has become a pressing concern due to the surge in urbanization, industrialization, and population growth, resulting in increased pollution levels and the introduction of emerging contaminants (ECs) into the environment.
Dibyanshu, Marco Kern, Traugott Scheytt
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Scaffoldings of totally positive matrices and line insertion
Linear and Multilinear Algebra, 2022 Given a totally positive matrix, can one insert a line (row or column) between two given lines while maintaining total positivity? This question was first posed and solved by Johnson and Smith who gave an algorithm that results in one possible line insertion. In this work we revisit this problem.
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
The approximation of a totally positive band matrix by a strictly banded totally positive one [PDF]
, 1982 Every nonsingular totally positive m-banded matrix is shown to be the product of m totally positive one-banded matrices and, therefore, the limit of strictly m-banded totally positive matrices.
Pinkus, Allan, de Boor, Carl
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
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HeliyonThe main purpose of this study was to assess metal(loid) concentrations in drinking water and urine samples from adults in Qom, Iran. Additionally, the study aimed to analyze these concentrations based on age, sex, and season, and to investigate the ...
Leila Kazemizad +6 more
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
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On the boundary of totally positive upper triangular matrices [PDF]
, 1995 Let B+ ⊂ GLn (R) denote the subgroup of upper triangular n × n matrices with positive entries on the main diagonal. A matrix M ∈ B+ is called totally positive if the determinants of all its minors not containing a row or column lying completely under the
Shapiro, B.Z., Shapiro, M.Z.
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