Results 51 to 60 of about 10,628 (259)

Characterizations of rectangular totally and strictly totally positive matrices

open access: yes, 2010
An n×m real matrix A is said to be totally positive (strictly totally positive) if every minor is nonnegative (positive). In this paper, we study characterizations of these classes of matrices by minors, by their full rank factorization and by their thin
Ricarte, Beatriz   +2 more
core   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Weak interlacing properties of totally positive matrices

open access: yes, 1985
We prove certain interlacing inequalities for the eigenvalues of totally positive ...
Friedland, Shmuel
core   +1 more source

On Totally Geodesic Submanifolds

open access: yesAxioms
We give a proof of Cartan’s Theorem on totally geodesic submanifolds for real analytic manifolds endowed with a real analytic, torsion-free, affine connection. We apply the theorem to real analytic Hadamard manifolds and, more generally, to real analytic
Antonella Nannicini, Donato Pertici
doaj   +1 more source

Scaffoldings of totally positive matrices and line insertion

open access: yesLinear and Multilinear Algebra, 2022
Given a totally positive matrix, can one insert a line (row or column) between two given lines while maintaining total positivity? This question was first posed and solved by Johnson and Smith who gave an algorithm that results in one possible line insertion. In this work we revisit this problem.
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Coherence Matrix Estimation With Total Positivity Regularization for Interferometric Phase Linking

open access: yesIEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Interferometric phase linking has become a critical step in distributed scatterer interferometry, yet its performance is significantly affected by inaccuracies in the coherence matrix and its inverse, such as the precision matrix.
Changjun Zhao, Yan Yan, Hanwen Yu
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Surjectivity and invertibility properties of totally positive matrices

open access: yes, 1982
A new “finite section” type theorem is used to show that the members of an interesting class of bounded totally positive matrices map l∞ onto l∞ if and only if their range contains a vector which alternates in sign and has coordinates bounded away from ...
Demko, Stephen
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

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