Results 61 to 70 of about 45,774 (276)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Totally positive completions for monotonically labeled block clique graphs
, 2009 It is shown that if the connected graph of the specified entries of a combinatorially symmetric, partial totally positive matrix is monotonically labeled block clique, then there is a totally positive completion.
Johnson, Charles R. +2 more
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
DiagnosticsA hypothesis-forming exploratory cross-sectional assessment was conducted to assess the occurrence and relevance of Gram-positive rod-shaped bacteria like Corynebacterium spp. and Actinomycetaceae in human urine samples. In total, 1170 urine samples from
Hagen Frickmann +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
The totally nonnegative completion problem
, 1998 An n-by-n real matrix is said to be totally positive (nonnegative) if every minor (principal and non-principal) is positive (nonnegative). The totally nonnegative completion problem asks which partially totally nonnegative matrices have a completion to a
Johnson, Charles R +5 more
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
مجله آب و خاک, 2017 Introduction: Soil forms a thin layer over the surface of the earth that performs many essential life processes . Soil has always been important to humans and their health, providing a resource that can be used for shelter and food production.
A. Afshari, H. Khademi, P. Alamdari
doaj +1 more source
Factorization of totally positive, symmetric, periodic, banded matrices with applications
, 1993 We show that a totally positive, symmetric, periodic, banded matrix A can be factored in a symmetric manner into positive one-banded periodic factors and deduce from this that A has positive eigenvalues with certain restrictions on their coincidence and ...
Goodman, T.N.T., Sharma, A.
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source