Results 71 to 80 of about 45,782 (275)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

The linear interpolation problem for totally positive matrices [PDF]

, 2004
It is shown that for two real vectors x,y there is a totally positive matrix A such that Ax=y if and only if a certain refinement of a classical (sign) variation diminishing relationship between x and y is ...
Johnson, Charles R., Gekhtman, Michael
core   +1 more source

Emilin1 gene and essential hypertension: a two-stage association study in northern Han Chinese population

BMC Medical Genetics, 2009
Background Elastogenesis of elastic extracellular matrix (ECM) which was recognized as a major component of blood vessels has been believed for a long time to play only a passive role in the dynamic vascular changes of typical hypertension.
Huang Jianfeng, Chen Shufeng, Wang Laiyuan, Hou Liping, Liu Xiaoli, Zhao Qi, Li Yun, Lu Xiangfeng, Shen Chong, Gu Dongfeng   +9 more
doaj   +1 more source

Another Proof of the Total Positivity of the Discrete Spline Collocation Matrix

Journal of Approximation Theory, 1996
In [J. Approximation Theory 84, No. 3, 247-264 (1996; Zbl 0863.41006)] \textit{K. M. Mørken} gave necessary and sufficient conditions for a minor of a discrete B-spline collocation matrix to be strictly positive, correcting an earlier theorem of \textit{R. Q. Jia} [J. Approximation Theory 39, 11-23 (1983; Zbl 0515.41010)].
openaire   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

A class of totally positive P-matrices whose inverses are M-matrices [PDF]

, 2007
In this work we introduce some technical conditions to prove that a P-matrix has an inverse M-matrix.
Gassó, M., Torregrosa, Juan R.
core   +1 more source

UPLC-MS/MS determination of 71 neuropsychotropic drugs in human serum

Heliyon
In this study, a UPLC-MS/MS method was developed for the rapid detection of 71 neuropsychotropic drugs in human serum for drug concentration monitoring and toxicity screening.
Weifeng Jin, Jianhua Wang, Shuzi Chen, Qing Chen, Dan Li, Mengyuan Zhu, Xiaomei Fu, Yingyu Huang, Ping Lin   +8 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Antibiotic Resistance and Biofilm Production in Catalase-Positive Gram-Positive Cocci Isolated from Brazilian Pasteurized Milk

Journal of Food Quality and Hazards Control, 2020
Background: Milk is a reservoir for several groups of microorganisms, which may pose health risks. The aim of this work was to assess the antibiotic resistance and biofilm production in catalase-positive Gram-positive cocci isolated from Brazilian ...
M.A.A. Machado, W.A. Ribeiro, V.S. Toledo, G.L.P.A. Ramos, H.C. Vigoder, J.S. Nascimento   +5 more
doaj  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source