Results 61 to 70 of about 484,502 (151)
, 2017 The main therapeutic basis for a case of organophosphate poisoning is a combination therapy which includes atropine as an anticholinergic drug and pralidoxime.
Babak Mostafazadeh +3 more
core +2 more sources
Annals of Gastroenterological Surgery, Volume 10, Issue 5, Page 1586-1593, September 2026.This study identifies the preoperative lymphocyte‐to–C‐reactive protein ratio (LCR) as a potent and independent biomarker for predicting surgical site infection (SSI) in pediatric patients undergoing major surgery for ulcerative colitis. ROC analysis established an optimal cutoff of 5000 (AUC: 0.80), which demonstrated robust predictive performance ...
Yuhki Koike +9 more
wiley +1 more source
Toxic Megacolon leading to bowel perforation: A rare adverse effect of bortezomib
, 2023 Bortezomib is a chemotherapeutic drug used in the treatment of multiple myeloma and amyloidosis. The major dose-limiting adverse effect is neuropathy. Although rare, autonomic involvement of the gastrointestinal tract, can present with ileus. We report a
Sitaraman, Karthikeyan +3 more
core +1 more source
Toxic Megacolon in Granulomatous Colitis [PDF]
, 1973 Acute, toxic dilatation of the colon in granulomatous colitis occurs more frequently than heretofore reported, and is a more serious complication than its counterpart in ulcerative colitis.
De Marco, V. +2 more
core +1 more source
Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.In infants with necrotising enterocolitis (NEC), excessive inflammation and epithelial cell death promote the epithelial–mesenchymal transition (EMT), leading to damage to intestinal barriers and the translocation of bacteria and toxins. In addition, inflamed epithelia release cytokines to strengthen the inflammatory response.
Xiao‐Chen Liu +12 more
wiley +1 more source
Management of Refractory and Difficult‐To‐Treat Inflammatory Bowel Disease: An Expert Opinion Review
JCC Plus, Volume 1, Issue 5, September 2026.This expert opinion offers a practical framework for refractory and difficult‐to‐treat IBD: confirm inflammation objectively, distinguish pharmacologic from structural and functional disease, and then escalate. Across ten clinical questions, the evidence is often limited to case series, and the resulting statements are identified as expert opinion ...
Filiz Akyuz +10 more
wiley +1 more source
British Journal of Clinical Pharmacology, Volume 92, Issue 8, Page 2723-2740, August 2026.Aims Paediatric pharmacokinetics differ significantly from adults due to age‐related physiological changes, necessitating precise dose adjustments. However, data on therapeutic drug monitoring (TDM) implementation in paediatric setting remain limited.
Gianluca Gazzaniga +20 more
wiley +1 more source
A Case of Ulcerative Colitis Accompanied by Hemolytic Uremic Syndrome
Turkish Journal of Nephrology, 2019 Hemolytic uremic syndrome (HUS) is a disease presenting with nonimmune hemolytic anemia, renal impairment and low platelet count. Escherichia coli serotype O157:H7 is the most common bacterial strain in typical HUS.
Nilay ŞENGÜL SAMANCI +6 more
doaj
Pyridyl‐Imidazopyridine Derivatives Displaying Submicromolar Activity Against Trypanosoma cruzi
ChemMedChem, Volume 21, Issue 13, 14 July 2026.Previously reported pyridyl‐thiazoles and highly active imidazopyridines against Trypanosoma cruzi inspired the design of a new series of pyridyl‐substituted imidazopyridines. Among the synthesized compounds, 5h emerged as the most promising derivative, displaying potent trypanocidal activity (EC50 = 0.16 μM), excellent selectivity (SI > 1250), and ...
Ana Carolina Rocha Barreto +9 more
wiley +1 more source
Journal of Interdisciplinary Medicine, 2019 Background:Clostridium difficile (CD) is the major cause of nosocomial antibiotic-associated infections, having as main manifestation diarrhea and life-threatening inflammation of the colon.
Suciu Nicolae +3 more
doaj +1 more source