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Impact of Clostridioides difficile Reporting on Antimicrobial Therapy Days Directed at Treatment of C. difficile Infections [PDF]
Antimicrobial Stewardship & Healthcare EpidemiologyBackground: Previous studies have found that solely relying on molecular testing is likely to result in the overdiagnosis and overtreatment of C. difficile infections (CDI). Comparable outcomes have been demonstrated in patients with a positive molecular
Ardath Plauche +2 more
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Transmission Patterns of Clostridioides difficile in a Non-Epidemic Setting Based on WGS Analysis
Microbiology Research, 2022 Clostridioides difficile is a major nosocomial pathogen and has a considerable burden on healthcare systems. Our objective was to determine the transmission patterns of C. difficile in a non-epidemic setting using whole-genome multi-locus sequence typing
Virginie Courbin +6 more
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Heliyon, 2023 Background: We performed molecular epidemiological analyses of Clostridioides difficile isolates in a university hospital in Japan to reveal the risk of C. difficile infection.
Yukitaka Ito +8 more
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Clinical complications in patients with primary and recurrent infection: A real-world data analysis
SAGE Open Medicine, 2021 Objective: Clostridioides difficile infection and recurrent C. difficile infection result in substantial economic burden and healthcare resource use. Sepsis and bowel surgery are known to be serious complications of C. difficile infection.
Paul Feuerstadt +6 more
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Frontiers in Cellular and Infection Microbiology, 2023 IntroductionClostridioides difficile (C. difficile) is a nosocomial bacterial pathogen that causes antibiotic-associated diarrhea mediated by cellular exotoxins secreted into the intestine during bacterial growth.
Yuan Yuan Wang +10 more
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Comparison of Diagnostic Algorithms for Detecting Toxigenic Clostridium difficile in Routine Practice at a Tertiary Referral Hospital in Korea. [PDF]
PLoS ONE, 2016 Since every single test has some limitations for detecting toxigenic Clostridium difficile, multistep algorithms are recommended. This study aimed to compare the current, representative diagnostic algorithms for detecting toxigenic C.
Hee-Won Moon +5 more
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Gut microbiota patterns associated with colonization of different Clostridium difficile ribotypes. [PDF]
PLoS ONE, 2013 C. difficile infection is associated with disturbed gut microbiota and changes in relative frequencies and abundance of individual bacterial taxons have been described.
Jure Skraban +5 more
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Development of TaqMan-based quantitative PCR for sensitive and selective detection of toxigenic Clostridium difficile in human stools. [PDF]
PLoS ONE, 2014 Clostridium difficile is the main cause of nosocomial diarrhea, but is also found in asymptomatic subjects that are potentially involved in transmission of C. difficile infection. A sensitive and accurate detection method of C.
Hiroyuki Kubota +6 more
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Gut Microbes, 2021 Clostridioides difficile disproportionally affects the elderly living in nursing homes (NHs). Our objective was to explore the prevalence of C. difficile in NH elders, over time and to determine whether the microbiome or other clinical factors are ...
John P. Haran +7 more
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New Microbes and New Infections, 2019 Pathogenesis of Clostridium difficile has been linked to production of toxins, including the large toxins A and B as well as the binary toxin CDT. Until recently, toxin A was only found in combination in clinical strains with the toxin B, unlike toxin B ...
J.-C. Marvaud +4 more
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