Results 21 to 30 of about 18,984,511 (231)

Clostridium difficile spore-macrophage interactions: spore survival. [PDF]

open access: yesPLoS ONE, 2012
BACKGROUND: Clostridium difficile is the main cause of nosocomial infections including antibiotic associated diarrhea, pseudomembranous colitis and toxic megacolon. During the course of Clostridium difficile infections (CDI), C.
Daniel Paredes-Sabja   +4 more
doaj   +1 more source

Bile acid-independent protection against Clostridioides difficile infection.

open access: yesPLoS Pathogens, 2021
Clostridioides difficile infections occur upon ecological / metabolic disruptions to the normal colonic microbiota, commonly due to broad-spectrum antibiotic use.
Andrea Martinez Aguirre   +8 more
doaj   +1 more source

Clostridium difficile–associated Disease in New Jersey Hospitals, 2000–2004

open access: yesEmerging Infectious Diseases, 2007
Recent emergence of a virulent strain of Clostridium difficile demonstrates the importance of tracking C. difficile incidence locally. Our survey of New Jersey hospitals documented increases in the rates of C. difficile disease (by 2-fold), C.
Esther T. Tan   +5 more
doaj   +1 more source

Inhibition of spores to prevent the recurrence of Clostridioides difficile infection - A possibility or an improbability?

open access: yesJournal of Microbiology, Immunology and Infection, 2021
Clostridioides difficile is one of the most common nosocomial gastrointestinal pathogens, and recurrence is a problematic issue because approximately 20–30% of patients experience at least one episode of recurrence, even after treatment with a ...
Chun-Wei Chiu   +4 more
doaj   +1 more source

Gut Microbiota Diversity of Preterm Neonates Is Associated With Clostridioides Difficile Colonization

open access: yesFrontiers in Cellular and Infection Microbiology, 2022
In adults, Clostridioides difficile infections are associated with alterations of the intestinal bacterial populations. Although preterm neonates (PN) are frequently colonized by C. difficile, limited data are available regarding the relationship between
Jeanne Couturier   +13 more
doaj   +1 more source

Transcriptional analysis of temporal gene expression in germinating Clostridium difficile 630 endospores. [PDF]

open access: yes, 2013
Clostridium difficile is the leading cause of hospital acquired diarrhoea in industrialised countries. Under conditions that are not favourable for growth, the pathogen produces metabolically dormant endospores via asymmetric cell division.
Fairweather, NF   +24 more
core   +1 more source

Exogenous butyrate inhibits butyrogenic metabolism and alters virulence phenotypes in Clostridioides difficile

open access: yesmBio
The gut microbiome engenders colonization resistance against the diarrheal pathogen Clostridioides difficile, but the molecular basis of this colonization resistance is incompletely understood.
Daniel A. Pensinger   +5 more
doaj   +1 more source

Identification of a novel zinc metalloprotease through a global analysis of clostridium difficile extracellular proteins [PDF]

open access: yes, 2013
Clostridium difficile is a major cause of infectious diarrhea worldwide. Although the cell surface proteins are recognized to be important in clostridial pathogenesis, biological functions of only a few are known.
Maria Scarselli (247406)   +39 more
core   +1 more source

Prevalence of Clostridium difficile infections among Kenyan children with diarrhea

open access: yesInternational Journal of Infectious Diseases, 2019
Background: Diarrhea causes significant morbidity and mortality among children worldwide. Regions most affected by diarrhea include Sub-Saharan Africa and Southeast Asia, where antibiotics are in common use and can make children more vulnerable to ...
Kimberly Plants-Paris   +8 more
doaj   +1 more source

Genetically Programmed Shape‐Morphing of Engineered Living Materials

open access: yesAdvanced Functional Materials, EarlyView.
Here, bacterial and mammalian engineered living materials (ELMs) are presented, in which living cells direct genetically programmed and enzymatically mediated shape‐morphing. The resulting deformation and shape‐recovery can be actuated in a genetically controlled manner by an ELM incorporating out‐of‐equilibrium counteracting biochemical reactions with
Jan Becker   +7 more
wiley   +1 more source

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