Results 41 to 50 of about 18,984,511 (231)

Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae

Advanced Science, EarlyView.
Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch, Muhammad D. Ariadi, Min Jung Kwun, Leonie Howells, Saiveth Hernandez‐Hernandez, Nicholas J. Croucher, Pedro J. Ballester   +6 more
wiley   +1 more source

Biofilms harbour Clostridioides difficile, serving as a reservoir for recurrent infection

npj Biofilms and Microbiomes, 2021
C. difficile infection (CDI) is a worldwide healthcare problem with ~30% of cases failing primary therapy, placing a burden on healthcare systems and increasing patient morbidity. We have little understanding of why these therapies fail.
Charmaine Normington, Ines B. Moura, Jessica A. Bryant, Duncan J. Ewin, Emma V. Clark, Morgan J. Kettle, Hannah C. Harris, William Spittal, Georgina Davis, Matthew R. Henn, Christopher B. Ford, Mark H. Wilcox, Anthony M. Buckley   +12 more
doaj   +1 more source

Investigation into the mobile genetic elements of Clostridium difficile [PDF]

, 2013
Clostridium difficile is a pathogenic bacterium that can colonise both humans and various animals. Toxin production leads to clinical symptoms ranging from mild to severe diarrhoea and can result in potentially fatal pseudomembranous colitis.
Brouwer, MSM
core  

Calprotectin and lactoferrin faecal levels in patients with Clostridium difficile infection (CDI): a prospective cohort study. [PDF]

, 2014
Measurement of both calprotectin and lactoferrin in faeces has successfully been used to discriminate between functional and inflammatory bowel conditions, but evidence is limited for Clostridium difficile infection (CDI).
Beadsworth, Mike B.J., Swale, Andrew, Mike B J Beadsworth, Munir Pirmohamed (40546), Andrew Swale, Kolamunnage-Dona, Ruwanthi, Chris M Parry, Little, Margaret, Hall, Amanda, Nick J. Beeching (623705), Parry, Chris M, Miyajima, Fabio, Paul Roberts (208537), Roberts, Paul, Fabio Miyajima, Amanda Hall, Ruwanthi Kolamunnage-Dona, Paul Roberts, Mike B. J. Beadsworth (623704), Pirmohamed, Munir, Chris M. Parry (304425), Beeching, Nick J, Munir Pirmohamed, Nick J Beeching, Beeching, Nicholas, Margaret Little (623703), Fabio Miyajima (208536), Andrew Swale (208539), Ruwanthi Kolamunnage-Dona (623706), Margaret Little, Parry, Christopher, Beadsworth, Mike BJ, Amanda Hall (210816)   +32 more
core   +1 more source

F‐Type Pyocin Versus Phage λ Tail: Conserved Hub, Divergent Fibers

Advanced Science, EarlyView.
Near‐atomic cryo‐EM structures of a Gram‐negative F‐type pyocin reveal a conserved tail tip architecture shared with bacteriophage λ together with a previously unrecognized side‐fiber attachment mode. These findings provide new insight into tailocin assembly and host recognition and establish a structural framework for engineering precision ...
Zhiwei Gu, Yufan Xie, Lanxin Wang, Luyan Ma, Xiaofei Ge, Jiawei Wang   +5 more
wiley   +1 more source

The association between histamine 2 receptor antagonist use and Clostridium difficile infection: a systematic review and meta-analysis. [PDF]

, 2013
Background Clostridium difficile infection (CDI) is a major health problem. Epidemiological evidence suggests that there is an association between acid suppression therapy and development of CDI.
Sutton, AJ, Aref A. Bin. Abdulhak, Abdulhak Aref A. Bin., Hernandez, Adrian V., Imad M. Tleyjeh (104252), AlGhamdi, Mushabab, Alex J Sutton, Patricia J. Erwin, Muhammad Riaz (104236), Erwin, Patricia J., Mushabab AlGhamdi (112556), Baddour, LM, Alasmari Faisal A., Baddour, Larry M., Alasmari, Faisal A., Sutton, Alex J., Faisal A. Alasmari, Alasmari, FA, Faisal A. Alasmari (112549), F. A. Alasmari (7656575), A. R. Khan (3951662), Mushabab Alghamdi, AlGhamdi Mushabab, Alex J. Sutton, Khan, AR, Aref A. Bin. Abdulhak (385158), Tleyjeh, IM, I. M. Tleyjeh (7656566), Alex J. Sutton (112577), Garbati Musa A., L. M. Baddour (7656596), M. A. Garbati (7656578), Imad M. Tleyjeh, M. Alghamdi (7687019), Imad M Tleyjeh, Khan Abdur Rahman, Al-Tannir, M, Patricia J Erwin, Muhammad Riaz, Abdur Rahman Khan (104234), Tleyjeh, Imad M., Garbati, MA, Aref Bin Abdulhak, A. B. Abdulhak (7687013), Erwin, PJ, Sutton Alex J., M. Riaz (7656572), Garbati, Musa A., Riaz Muhammad, Abdulhak, Aref A. Bin., Musa A Garbati, M. Al-Tannir (7687016), Mohamad Al-Tannir, Patricia J. Erwin (104246), Abdur Rahman Khan, Al-Tannir Mohamad, A. J. Sutton (7648487), Alghamdi, M, Faisal A Alasmari, Musa A. Garbati, Erwin Patricia J., Larry M Baddour, Baddour Larry M., P. J. Erwin (7656587), Abdulhak, AB, Larry M. Baddour (104249), Riaz, Muhammad, Riaz, M, Khan, Abdur Rahman, Al-Tannir, Mohamad, Tleyjeh Imad M., Mohamad Al-Tannir (385159), Musa A. Garbati (104244), Larry M. Baddour   +73 more
core   +1 more source

Programming Gut Microbiome Function Through Cross‐Feeding: From Ecological Mechanisms to Live Biotherapeutics

Advanced Science, EarlyView.
This graphical abstract presents gut microbial cross‐feeding through a Mechanism–Technology–Application framework. It summarizes major resource‐transfer modes, the experimental and computational tools used to establish causality, and potential interventions involving dietary substrates, live biotherapeutic products, and engineered microbes.
Chuankai Sun, Teng Ma, Hao Jin, Zelong Li, Yi Cheng, Jingjin Li, Lai‐Yu Kwok, Zhihong Sun   +7 more
wiley   +1 more source

Interactions Between Clostridioides difficile and Fecal Microbiota in in Vitro Batch Model: Growth, Sporulation, and Microbiota Changes

Frontiers in Microbiology, 2018
Disturbance in gut microbiota is crucial for the development of Clostridioides difficile infection (CDI). Different mechanisms through which gut microbiota influences C. difficile colonization are known. However, C.
Sabina Horvat, Maja Rupnik, Maja Rupnik
doaj   +1 more source

Impact of Postoperative Infectious Complications on Long‐Term Survival After Curative Resection for Colorectal Cancer: A Multicenter Study in the Minimally Invasive Era

Annals of Gastroenterological Surgery, EarlyView.
Postoperative infectious complications (PICs) have been associated with poor long‐term outcomes after colorectal cancer surgery, but evidence in the modern minimally invasive era remains limited. In this multicenter cohort of 5377 patients undergoing curative resection, PICs were independently associated with worse overall survival and relapse‐free ...
Takehito Yamamoto, Ryosuke Mizuno, Yoshiro Itatani, Tetsuya Shiota, Masahiro Yamada, Tadayoshi Yamaura, Mami Yoshitomi, Kazutaka Obama   +7 more
wiley   +1 more source

Elucidating human gut microbiota interactions that robustly inhibit diverse Clostridioides difficile strains across different nutrient landscapes

Nature Communications
The human gut pathogen Clostridioides difficile displays substantial inter-strain genetic variability and confronts a changeable nutrient landscape in the gut. We examined how human gut microbiota inter-species interactions influence the growth and toxin
Jordy Evan Sulaiman, Jaron Thompson, Yili Qian, Eugenio I. Vivas, Christian Diener, Sean M. Gibbons, Nasia Safdar, Ophelia S. Venturelli   +7 more
doaj   +1 more source