Results 51 to 60 of about 18,984,511 (231)

Bacterial metabolites influence the autofluorescence of Clostridioides difficile

open access: yesFrontiers in Microbiology
Clostridioides difficile is a bacterial pathogen that has been implicated in severe gastrointestinal infections. C. difficile has intrinsic green autofluorescence and the level of this autofluorescence is known to be increased by growth time and oxygen ...
Taylor D. Ticer   +12 more
doaj   +1 more source

Interspecies Interactions between Clostridium difficile and Candida albicans

open access: yesmSphere, 2016
The facultative anaerobic polymorphic fungus Candida albicans and the strictly anaerobic Gram-positive bacterium Clostridium difficile are two opportunistic pathogens residing in the human gut.
Pim T. van Leeuwen   +8 more
doaj   +1 more source

Development of an Effective Nontoxigenic Clostridioides difficile–Based Oral Vaccine against C. difficile Infection

open access: yesMicrobiology Spectrum, 2022
The symptoms of Clostridioides difficile infection (CDI) are largely attributed to two C. difficile toxins, TcdA and TcdB. Significant efforts have been devoted to developing vaccines targeting both toxins through parenteral immunization routes. Recently,
Shaohui Wang, Duolong Zhu, Xingmin Sun
doaj   +1 more source

Targeting B‐Cell‐Activating Factor and Its Receptor in Immune Thrombocytopenia and Warm Autoimmune Hemolytic Anemia

open access: yesAmerican Journal of Hematology, EarlyView.
ABSTRACT Current treatments for immune thrombocytopenia (ITP) and warm autoimmune hemolytic anemia (wAIHA), rare autoimmune diseases in which autoreactive B cells play a major role, can lead to high response rates; however, for many patients these responses are not durable or maintained after treatment discontinuation.
Matthieu Mahévas   +4 more
wiley   +1 more source

Gut Health in Ostriches (Struthio camelus): Insights Into Intestinal Structure, Functions, Microbiome, and Improvement Strategies

open access: yesAnimal Research and One Health, EarlyView.
Our paper systematically reviews the intestinal structure, function, and microbiota of ostriches, along with strategies for improving their gut health. We analyze how these factors collectively influence intestinal homeostasis and ostrich welfare, emphasizing probiotics as a promising intervention to enhance gut health, boost population well‐being, and
Zi‐Qun Zhang   +6 more
wiley   +1 more source

Oral vancomycin solution is superior to capsule in inducing clinical biomarker and endoscopic remission in children with atypical ulcerative colitis

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims Atypical colitis (presenting reverse gradient colitis, backwash ileitis or rectal sparing) is associated with primary sclerosing cholangitis–ulcerative colitis (PSC). Oral vancomycin has been used to manage paediatric atypical colitis with/without confirmed PSC. Different preparations had shown different efficacy.
Laura Räisänen   +4 more
wiley   +1 more source

Novel insights into phage biology of the pathogen Clostridioides difficile based on the active virome

open access: yesFrontiers in Microbiology
The global pathogen Clostridioides difficile is a well-studied organism, and researchers work on unraveling its fundamental virulence mechanisms and biology. Prophages have been demonstrated to influence C.
Miriam A. Schüler   +2 more
doaj   +1 more source

Myxopyronin B inhibits growth of a Fidaxomicin-resistant Clostridioides difficile isolate and interferes with toxin synthesis

open access: yesGut Pathogens, 2022
The anaerobic, gastrointestinal pathogen Clostridioides difficile can cause severe forms of enterocolitis which is mainly mediated by the toxins it produces.
Madita Brauer   +5 more
doaj   +1 more source

Homophily‐adjusted social influence estimation

open access: yesCanadian Journal of Statistics, EarlyView.
Abstract Homophily and social influence are two key concepts of social network analysis. Distinguishing between these phenomena is difficult, and approaches to disambiguate the two have been primarily limited to longitudinal data analyses. In this study, we provide sufficient conditions for valid estimation of social influence through cross‐sectional ...
Hanh T.D. Pham, Daniel K. Sewell
wiley   +1 more source

Negative interactions determine Clostridioides difficile growth in synthetic human gut communities

open access: yesMolecular Systems Biology, 2021
Understanding the principles of colonization resistance of the gut microbiome to the pathogen Clostridioides difficile will enable the design of defined bacterial therapeutics.
Susan Hromada   +7 more
doaj   +1 more source

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