Results 101 to 110 of about 546,003 (354)
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
Acute spontaneous and experimental poisoning by Solanum pseudoquina in cattle [PDF]
Pesquisa Veterinária Brasileira: The epidemiology, toxic potential, and clinical and pathological presentation of acute spontaneous and experimental poisoning by Solanum pseudoquina are described.
Elaine Melchioretto +4 more
doaj +1 more source
Tropane alkaloids in food [PDF]
A large number of wild and cultured plants produce secondary metabolites that are toxic to humans and animals. Through accidental or intentional mixing of these plants with normal food and feed the consumers of these products will be exposed to the ...
Adamse, P., Egmond, H.P., van
core +1 more source
Molecular Oncology, EarlyView.The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine +10 more
wiley +1 more source
Molecular Oncology, EarlyView.In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop +10 more
wiley +1 more source
Journal of Medicinal Plants, 2019 Background: Because in todaychr('39')s societies, not only the nutritional role of plants and fungi is very high, but also the main basis of many drugs are plants and plant products, therefore one of the problems of clinical toxicologists is the toxicity
S Sattarzad Fathi +4 more
doaj
Plantas tóxicas para ruminantes e equídeos do estado de Sergipe
Pesquisa Veterinária BrasileiraRESUMO: Em um levantamento feito nos anos de 2015 e 2016 no estado de Sergipe, com o objetivo de conhecer as plantas tóxicas para ruminantes e equídeos, foram visitadas propriedades rurais em 16 municípios, englobando as mesorregiões do litoral, agreste ...
Eduardo M. Nascimento +2 more
doaj +1 more source
No-cost meals might not exist for insects feeding on toxic plants. [PDF]
Biol Open, 2023 Pokharel P.
europepmc +1 more source
Involvement of the leaf-specific multidrug and toxic compound extrusion (MATE) transporter Nt-JAT2 in vacuolar sequestration of nicotine in Nicotiana tabacum [PDF]
, 2014 Alkaloids play a key role in higher plant defense against pathogens and herbivores. Following its biosynthesis in root tissues, nicotine, the major alkaloid of Nicotiana species, is translocated via xylem transport toward the accumulation sites, leaf ...
Goossens, Alain +11 more
core +4 more sources