Veterinary and Comparative Oncology, Volume 24, Issue 2, Page 229-239, June 2026.ABSTRACT Radiation therapy (RT) has emerged as a promising non‐surgical approach for treating canine adrenal tumours. This multi‐institutional, retrospective study describes clinical outcomes for 21 dogs having been prescribed a course of hypofractionated image‐guided intensity‐modulated RT (IMRT) entailing delivery of 25–35 Gy total in 5 fractions ...
Yen‐Hao Erik Lai +4 more
wiley +1 more source
Case Report: Fulminant shock due to PVL-positive <i>Staphylococcus aureus</i> in an adolescent-superantigen-negative sepsis with toxic shock-like features. [PDF]
Front Med (Lausanne)Attou R +4 more
europepmc +1 more source
Molecular Oncology, Volume 20, Issue 5, Page 1220-1236, May 2026.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Streptococcus mitis Cellulitis Progressing to Severe Sepsis, Septic Shock, and Suspected Toxic Shock Syndrome in a Previously Healthy Child. [PDF]
CureusGuignan O +5 more
europepmc +1 more source
Advanced Science, Volume 13, Issue 26, 8 May 2026.We established patient‐derived SWN cell lines and orthotopic PDX models that recapitulate patient pain phenotypes, alongside a novel intravital DRG imaging platform to track macrophage infiltration and neuronal pain responses. Using these models, we define HMGB1–CCL2–IL‐6 signaling crosstalk driving pain and identify EGF signaling as a key regulator of
Zhenzhen Yin +17 more
wiley +1 more source
Advanced Science, Volume 13, Issue 25, 4 May 2026.HSP90α is significantly upregulated in platelets from sepsis patients, with its origin from megakaryocyte‐derived trafficking. Furthermore, activated platelets secrete HSP90α into the extracellular space in both free and exosome‐associated forms. Finally, extracellular HSP90α directly engages TLR4 on neutrophils to induce autophagy, leading to NET ...
Chengbo Wang +17 more
wiley +1 more source
Rapid Proteome‐Wide Discovery of Protein–Protein Interactions With ppIRIS
Advanced Science, Volume 13, Issue 26, 8 May 2026.ppIRIS is a lightweight deep learning framework for proteome‐wide protein–protein interaction prediction directly from sequence. By fusing evolutionary and structural embeddings with a regularized Siamese architecture, ppIRIS achieves state‐of‐the‐art accuracy across species, enables minute‐scale screening, and reveals biologically validated bacterial ...
Luiz Felipe Piochi +4 more
wiley +1 more source
Toxic Shock Syndrome in a 45-Year-Old Woman Possibly Associated with Tampon Use: A Case Report of Multiorgan Failure Due to <i>Streptococcus agalactiae</i>. [PDF]
DiseasesZavidić T, Dejhalla E, Zahirović D.
europepmc +1 more source
Digital seed amplification assay for TDP‐43 aggregate quantification in CSF
Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.Abstract INTRODUCTION Dementia is commonly caused by underlying pathologies driven by misfolded protein aggregates. Although dementia subtypes have distinct mechanisms, overlapping symptoms make diagnosis without biomarkers difficult. Misdiagnosis has previously hindered drug development by enrolling patients non‐specifically in trials.
Ella Borberg +7 more
wiley +1 more source
Necrotizing Soft Tissue Infection at a Self-Administered Subcutaneous Etanercept Injection Site in an Immunosuppressed Patient With Rheumatoid Arthritis: A Case Report. [PDF]
CureusTai S +4 more
europepmc +1 more source