Results 1 to 10 of about 10,720 (171)
CD28: Direct and Critical Receptor for Superantigen Toxins
Toxins, 2013 Every adaptive immune response requires costimulation through the B7/CD28 axis, with CD28 on T-cells functioning as principal costimulatory receptor. Staphylococcal and streptococcal superantigen toxins hyperstimulate the T-cell-mediated immune response ...
Ziv Rotfogel +5 more
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Bacterial Superantigen Toxins, CD28, and Drug Development
Toxins, 2018 During severe bacterial infections, death and disease are often caused by an overly strong immune response of the human host. Acute toxic shock is induced by superantigen toxins, a diverse set of proteins secreted by Gram-positive staphylococcal and ...
Raymond Kaempfer
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Assessment of the Functional Regions of the Superantigen Staphylococcal Enterotoxin B
Toxins, 2013 The functional activity of superantigens is based on capacity of these microbial proteins to bind to both the β-chain of the T cell receptor (TcR) and the major histocompatibility complex (MHC) class II dimer.
Thomas J. Rogers, Lily Zhang
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Role of Infectious Agents in the Etiology of Kawasaki Disease [PDF]
Pediatric Infectious Disease, 2022 Kawasaki disease (KD) is a multisystemic childhood vasculitis that predominantly affects the coronary arteries. The constellation of clinical features in KD, such as, acute onset of fever, redness of lips and oral mucosa, rash, swelling over palms and ...
Aaqib Banday +2 more
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eLife, 2021 Influenza pandemics pose public health threats annually for lacking vaccine that provides cross-protection against novel and emerging influenza viruses.
Yansheng Li +11 more
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Pathogens, 2022 It has been posited SARS-CoV-2 contains at least one unique superantigen-like motif not found in any other SARS or endemic coronaviruses. Superantigens are potent antigens that can send the immune system into overdrive.
Adam Hamdy, Anthony Leonardi
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Binding of superantigen toxins into the CD28 homodimer interface is essential for induction of cytokine genes that mediate lethal shock. [PDF]
PLoS Biology, 2011 Bacterial superantigens, a diverse family of toxins, induce an inflammatory cytokine storm that can lead to lethal shock. CD28 is a homodimer expressed on T cells that functions as the principal costimulatory ligand in the immune response through an ...
Gila Arad +9 more
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Frontiers in Microbiology, 2022 Enterotoxins (SEs) produced by Staphylococcus aureus are the cause of serious food intoxications. Staphylococcal enterotoxin C (SEC) is one of the main contributors, as it is often highly expressed. S. aureus possesses a competitive growth advantage over
Danai Etter +5 more
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Experimental Dermatology, 1996 Abstract Superantigens are potent modulators of the immune system. Some of their biological and immunological properties are reviewed here with special attention to their potential significance for cutaneous inflammation, specific skin immune responses and skin diseases.
J, Saloga, E W, Gelfand, J, Knop
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Antigen-specific downregulation of miR-150 in CD4 T cells promotes cell survival
Frontiers in Immunology, 2023 MicroRNA-150 (miR-150) has been shown to play a general role in the immune system, but very little is known about its role on CD4+ T cell responses. During T cell responses against superantigen Staphylococcal Enterotoxin A, miR-150 expression was down ...
Antoine Ménoret +5 more
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