Results 31 to 40 of about 12,609 (207)

Epidemiology and distribution of 10 superantigens among invasive Streptococcus pyogenes disease in Germany from 2009 to 2014.

PLoS ONE, 2017
A nationwide laboratory-based surveillance study of invasive S. pyogenes infections was conducted in Germany. Invasive isolates (n = 719) were obtained between 2009 and 2014. Most isolates were obtained from blood (92.1%).
Matthias Imöhl, Christina Fitzner, Stephanie Perniciaro, Mark van der Linden   +3 more
doaj   +1 more source

Detection of Streptococcus pyogenes M1UK in Australia and characterization of the mutation driving enhanced expression of superantigen SpeA

, 2023
A new variant of Streptococcus pyogenes serotype M1 (designated ‘M1UK’) has been reported in the United Kingdom, linked with seasonal scarlet fever surges, marked increase in invasive infections, and exhibiting enhanced expression of the superantigen ...
Brouwer, Stephan, Pitt, Miranda E, De Oliveira, David MP, Cork, Amanda J, Harbison-Price, Nichaela, Taiaroa, George, Lacey, Jake A, Jespersen, Magnus G, Curren, Bodie F, Bertolla, Olivia M, Keller, Nadia, Davies, Mark R, Grimwood, Keith, Hayes, Andrew J, Mediati, Daniel G, et al.   +15 more
core   +1 more source

Marginal zone B-cells, a gatekeeper of innate immunity

Frontiers in Immunology, 2011
To maintain the integrity of an organism constantly challenged by pathogens, the immune system is endowed with a variety of cell types. B-lymphocytes were initially thought to only play a role in the adaptative branch of immunity.
Moncef eZOUALI, Yolande eRICHARD
doaj   +1 more source

Endogenous Superantigens Shape Response to Exogenous Superantigens [PDF]

Clinical and Vaccine Immunology, 2005
ABSTRACT Endogenous superantigen-mediated thymic negative selection resulted in a paucity of mature T cells bearing T-cell receptor (TCR) Vβ8 in the periphery. Consequently, the magnitude of immune response to exogenous superantigen staphylococcal enterotoxin B, which activates TCR Vβ8 + T cells, was ...
Govindarajan, Rajagopalan, Manisha, Singh, Moon M, Sen, Narayana S, Murali, Karl A, Nath, Chella S, David   +5 more
openaire   +2 more sources

Human Keratinocyte Response to Superantigens

mSphere, 2020
Staphylococcus aureus and Streptococcus pyogenes are significant human pathogens, causing infections at multiple body sites, including across the skin. Both are organisms that cause human diseases and secrete superantigens, including toxic shock syndrome
Patrick M. Schlievert, Francoise A. Gourronc, Donald Y. M. Leung, Aloysius J. Klingelhutz   +3 more
doaj   +1 more source

Superantigen antagonist peptides [PDF]

, 2001
The production of superantigenic exotoxins by Gram positive bacteria underlies the pathology of toxic shock syndrome. Future treatment strategies for superantigen-mediated diseases are likely to be directed at blocking the three-way interaction between ...
Jonathan Cohen (26835), Martin Llewelyn (4461757)   +1 more
core   +1 more source

Characterization of Staphylococcus aureus Enterotoxin L [PDF]

, 2003
Staphylococcus aureus causes a wide variety of diseases. Major virulence factors of this organism include enterotoxins (SEs) that cause both food poisoning and toxic shock syndrome.
Bohach, G. A., Gutierrez, J. A., Orwin, Paul M., Fitzgerald, Ross; id_orcid, Fitzgerald, J. Ross, Schlievert, Patrick M., Orwin, P. M., Bohach, Gregory A., Schlievert, P. M., Leung, D. Y. M., Leung, Donald Y. M., Gutierrez, Juan A.   +11 more
core   +1 more source

Characteristics of Group A Streptococcus Strains Circulating during Scarlet Fever Epidemic, Beijing, China, 2011

Emerging Infectious Diseases, 2013
Scarlet fever is one of a variety of diseases caused by group A Streptococcus (GAS). During 2011, a scarlet fever epidemic characterized by peak monthly incidence rates 2.9–6.7 times higher than those in 2006–2010 occurred in Beijing, China.
Peng Yang, Xiaomin Peng, Daitao Zhang, Shuangsheng Wu, Yimeng Liu, Shujuan Cui, Guilan Lu, Wei Duan, Weixian Shi, Shuang Liu, Jing Li, Quanyi Wang   +11 more
doaj   +1 more source

Viral Superantigens [PDF]

Mikrobiyoloji Bulteni, 2016
Superantigens (SAgs) are microbial proteins produced by various microorganisms that elicit excessive and strong stimulation of T cells via an unconventional mechanism. They cause polyclonal activation of T cells in a non-specific manner, by binding to a particular variable-beta (Vβ) chain of T-cell receptor (TCR) and MHC class II molecule, in ...
openaire   +2 more sources

Investigating Primary Biliary Cholangitis for a Human Betaretrovirus Superantigen signature

, 2022
Primary Biliary Cholangitis (PBC) is an idiopathic autoimmune disease characterized by destruction of small hepatic bile ducts and presence of antimitochondrial antibodies (AMA).
Syed, Hussain
core   +2 more sources