Results 21 to 30 of about 12,609 (207)

T cell activation or tolerization: the Yin and Yang of bacterial superantigens

Frontiers in Microbiology, 2015
Bacterial superantigens are exotoxins from pathogens which interact with innate and adaptive immune cells. The paradox that superantigens cause activation and inactivation/anergy of T-cells was soon recognized.
Aline eSähr, Sandra eFörmer, Dagmar eHildebrand, Klaus eHeeg   +3 more
doaj   +1 more source

Toxin exposure and HLA alleles determine serum antibody binding to toxic shock syndrome toxin 1 (TSST-1) of Staphylococcus aureus

Frontiers in Immunology, 2023
Life-threatening toxic shock syndrome is often caused by the superantigen toxic shock syndrome toxin-1 (TSST-1) produced by Staphylococcus aureus. A well-known risk factor is the lack of neutralizing antibodies.
Stefan Weiss, Stefan Weiss, Silva Holtfreter, Tanja C. Meyer, Frieder Schmiedeke, Clemens Cammann, Marcus Dörr, Marcus Dörr, Stephan B. Felix, Stephan B. Felix, Hans J. Grabe, Georg Homuth, Christian Kohler, Cedric Mahncke, Stephan Michalik, Matthias Nauck, Matthias Nauck, Nele Friedrich, Nele Friedrich, Stefanie Samietz, Henry Völzke, Henry Völzke, Uwe Völker, Uwe Völker, Barbara M. Bröker   +24 more
doaj   +1 more source

Superantigens, superantigen-like proteins and superantigen derivatives for cancer treatment.

European review for medical and pharmacological sciences, 2021
Bacterial superantigens (SAgs) are proteins produced by few types of bacteria that have been linked to several human diseases. Due to their potent in vitro and in vivo tumoricidal effects, they are extensively investigated for oncological applications either alone or in combination with classical anticancer drugs.
openaire   +2 more sources

Interactions between staphylococcal enterotoxins A and D and superantigen-like proteins 1 and 5 for predicting methicillin and multidrug resistance profiles among Staphylococcus aureus ocular isolates.

PLoS ONE, 2021
BackgroundMethicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant (MDR) S. aureus strains are well recognized as posing substantial problems in treating ocular infections. S.
Min Lu, Jean-Marie Parel, Darlene Miller
doaj   +1 more source

Apoptosis-mediated inhibition of human T-cell acute lymphoblastic leukemia upon treatment with Staphylococus Aureus enterotoxin-superantigen

Frontiers in Immunology, 2023
Patients with relapsed T cell acute lymphoblastic leukemia (T-ALL) have limited therapeutic options and poor prognosis. The finding of efficient strategies against this refractory neoplasm is a medical priority.
Alejandra Duarte, Alejandra Duarte, Daniela R. Montagna, Mercedes Pastorini, Mercedes Alemán   +4 more
doaj   +1 more source

Computational Construction of a Single-Chain Bi-Paratopic Antibody Allosterically Inhibiting TCR-Staphylococcal Enterotoxin B Binding

Frontiers in Immunology, 2021
Staphylococcal enterotoxin B (SEB) simultaneously crosslinks MHC class II antigen and TCR, promoting proliferation of T cells and releasing a large number of toxic cytokines.
Ganggang Bai, Yanhong Ge, Yuhong Su, Shuo Chen, Xingcheng Zeng, Huixia Lu, Buyong Ma, Buyong Ma   +7 more
doaj   +1 more source

Diversity of Functionally Distinct Clonal Sets of Human Conventional Memory B Cells That Bind Staphylococcal Protein A

Frontiers in Immunology, 2021
Staphylococcus aureus, a common cause of serious and often fatal infections, is well-armed with secreted factors that disarm host immune defenses. Highly expressed in vivo during infection, Staphylococcal protein A (SpA) is reported to also contribute to
Emily E. Radke, Emily E. Radke, Zhi Li, Zhi Li, David N. Hernandez, Hanane El Bannoudi, Sergei L. Kosakovsky Pond, Bo Shopsin, Peter Lopez, David Fenyö, David Fenyö, Gregg J. Silverman   +11 more
doaj   +1 more source

Novel SPEA Superantigen Peptide Agonists and Peptide Agonist-TGFαL3 Conjugate. In Vitro Study of Their Growth-Inhibitory Effects for Targeted Cancer Immunotherapy

, 2023
Bacterial superantigens (SAgs) are effective T-cell stimulatory molecules that lead to massive cytokine production. Superantigens crosslink between MHC class II molecules on the Antigen Presenting Cells (APC) and TCR on T-cells.
Sayed, G., Bashraheel, S. S.
core   +1 more source

Superantigen-Induced Proliferation of Human CD4+CD25− T Cells Is Followed by a Switch to a Functional Regulatory Phenotype

, 2010
Bacterial superantigens are potent T cell activators. In humans they cause toxic shock and scarlet fever, and they are implicated in Kawasaki’s disease, autoimmunity, atopy, and sepsis.
Martin J. Llewelyn, Amanda L Taylor (16048991), Amanda L. Taylor, Martin Llewelyn (4461757)   +3 more
core   +2 more sources

Superantigen Recognition and Interactions: Functions, Mechanisms and Applications

Frontiers in Immunology, 2021
Superantigens are unconventional antigens which recognise immune receptors outside their usual recognition sites e.g. complementary determining regions (CDRs), to elicit a response within the target cell.
Anthony M. Deacy, Samuel Ken-En Gan, Samuel Ken-En Gan, Jeremy P. Derrick   +3 more
doaj   +1 more source