Results 21 to 30 of about 10,170 (163)

Interactions between staphylococcal enterotoxins A and D and superantigen-like proteins 1 and 5 for predicting methicillin and multidrug resistance profiles among Staphylococcus aureus ocular isolates.

PLoS ONE, 2021
BackgroundMethicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant (MDR) S. aureus strains are well recognized as posing substantial problems in treating ocular infections. S.
Min Lu, Jean-Marie Parel, Darlene Miller
doaj   +1 more source

Endogenous Superantigens Shape Response to Exogenous Superantigens [PDF]

Clinical and Vaccine Immunology, 2005
ABSTRACT Endogenous superantigen-mediated thymic negative selection resulted in a paucity of mature T cells bearing T-cell receptor (TCR) Vβ8 in the periphery. Consequently, the magnitude of immune response to exogenous superantigen staphylococcal enterotoxin B, which activates TCR Vβ8 + T cells, was ...
Govindarajan, Rajagopalan, Manisha, Singh, Moon M, Sen, Narayana S, Murali, Karl A, Nath, Chella S, David   +5 more
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Apoptosis-mediated inhibition of human T-cell acute lymphoblastic leukemia upon treatment with Staphylococus Aureus enterotoxin-superantigen

Frontiers in Immunology, 2023
Patients with relapsed T cell acute lymphoblastic leukemia (T-ALL) have limited therapeutic options and poor prognosis. The finding of efficient strategies against this refractory neoplasm is a medical priority.
Alejandra Duarte, Alejandra Duarte, Daniela R. Montagna, Mercedes Pastorini, Mercedes Alemán   +4 more
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Computational Construction of a Single-Chain Bi-Paratopic Antibody Allosterically Inhibiting TCR-Staphylococcal Enterotoxin B Binding

Frontiers in Immunology, 2021
Staphylococcal enterotoxin B (SEB) simultaneously crosslinks MHC class II antigen and TCR, promoting proliferation of T cells and releasing a large number of toxic cytokines.
Ganggang Bai, Yanhong Ge, Yuhong Su, Shuo Chen, Xingcheng Zeng, Huixia Lu, Buyong Ma, Buyong Ma   +7 more
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Diversity of Functionally Distinct Clonal Sets of Human Conventional Memory B Cells That Bind Staphylococcal Protein A

Frontiers in Immunology, 2021
Staphylococcus aureus, a common cause of serious and often fatal infections, is well-armed with secreted factors that disarm host immune defenses. Highly expressed in vivo during infection, Staphylococcal protein A (SpA) is reported to also contribute to
Emily E. Radke, Emily E. Radke, Zhi Li, Zhi Li, David N. Hernandez, Hanane El Bannoudi, Sergei L. Kosakovsky Pond, Bo Shopsin, Peter Lopez, David Fenyö, David Fenyö, Gregg J. Silverman   +11 more
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Superantigen Recognition and Interactions: Functions, Mechanisms and Applications

Frontiers in Immunology, 2021
Superantigens are unconventional antigens which recognise immune receptors outside their usual recognition sites e.g. complementary determining regions (CDRs), to elicit a response within the target cell.
Anthony M. Deacy, Samuel Ken-En Gan, Samuel Ken-En Gan, Jeremy P. Derrick   +3 more
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Epidemiology and distribution of 10 superantigens among invasive Streptococcus pyogenes disease in Germany from 2009 to 2014.

PLoS ONE, 2017
A nationwide laboratory-based surveillance study of invasive S. pyogenes infections was conducted in Germany. Invasive isolates (n = 719) were obtained between 2009 and 2014. Most isolates were obtained from blood (92.1%).
Matthias Imöhl, Christina Fitzner, Stephanie Perniciaro, Mark van der Linden   +3 more
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Viral Superantigens [PDF]

Mikrobiyoloji Bulteni, 2016
Superantigens (SAgs) are microbial proteins produced by various microorganisms that elicit excessive and strong stimulation of T cells via an unconventional mechanism. They cause polyclonal activation of T cells in a non-specific manner, by binding to a particular variable-beta (Vβ) chain of T-cell receptor (TCR) and MHC class II molecule, in ...
openaire   +2 more sources

Marginal zone B-cells, a gatekeeper of innate immunity

Frontiers in Immunology, 2011
To maintain the integrity of an organism constantly challenged by pathogens, the immune system is endowed with a variety of cell types. B-lymphocytes were initially thought to only play a role in the adaptative branch of immunity.
Moncef eZOUALI, Yolande eRICHARD
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Superantigens, superantigen-like proteins and superantigen derivatives for cancer treatment.

European review for medical and pharmacological sciences, 2021
Bacterial superantigens (SAgs) are proteins produced by few types of bacteria that have been linked to several human diseases. Due to their potent in vitro and in vivo tumoricidal effects, they are extensively investigated for oncological applications either alone or in combination with classical anticancer drugs.
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