Results 21 to 30 of about 10,720 (171)
Frontiers in Immunology, 2023 Patients with relapsed T cell acute lymphoblastic leukemia (T-ALL) have limited therapeutic options and poor prognosis. The finding of efficient strategies against this refractory neoplasm is a medical priority.
Alejandra Duarte +4 more
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Frontiers in Immunology, 2021 Staphylococcal enterotoxin B (SEB) simultaneously crosslinks MHC class II antigen and TCR, promoting proliferation of T cells and releasing a large number of toxic cytokines.
Ganggang Bai +7 more
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Frontiers in Immunology, 2021 Staphylococcus aureus, a common cause of serious and often fatal infections, is well-armed with secreted factors that disarm host immune defenses. Highly expressed in vivo during infection, Staphylococcal protein A (SpA) is reported to also contribute to
Emily E. Radke +11 more
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Superantigen Recognition and Interactions: Functions, Mechanisms and Applications
Frontiers in Immunology, 2021 Superantigens are unconventional antigens which recognise immune receptors outside their usual recognition sites e.g. complementary determining regions (CDRs), to elicit a response within the target cell.
Anthony M. Deacy +3 more
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PLoS ONE, 2017 A nationwide laboratory-based surveillance study of invasive S. pyogenes infections was conducted in Germany. Invasive isolates (n = 719) were obtained between 2009 and 2014. Most isolates were obtained from blood (92.1%).
Matthias Imöhl +3 more
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Endogenous Superantigens Shape Response to Exogenous Superantigens [PDF]
Clinical and Vaccine Immunology, 2005 ABSTRACT Endogenous superantigen-mediated thymic negative selection resulted in a paucity of mature T cells bearing T-cell receptor (TCR) Vβ8 in the periphery. Consequently, the magnitude of immune response to exogenous superantigen staphylococcal enterotoxin B, which activates TCR Vβ8 + T cells, was ...
Govindarajan, Rajagopalan +5 more
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Marginal zone B-cells, a gatekeeper of innate immunity
Frontiers in Immunology, 2011 To maintain the integrity of an organism constantly challenged by pathogens, the immune system is endowed with a variety of cell types. B-lymphocytes were initially thought to only play a role in the adaptative branch of immunity.
Moncef eZOUALI, Yolande eRICHARD
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Mikrobiyoloji Bulteni, 2016 Superantigens (SAgs) are microbial proteins produced by various microorganisms that elicit excessive and strong stimulation of T cells via an unconventional mechanism. They cause polyclonal activation of T cells in a non-specific manner, by binding to a particular variable-beta (Vβ) chain of T-cell receptor (TCR) and MHC class II molecule, in ...
openaire +3 more sources
Human Keratinocyte Response to Superantigens
mSphere, 2020 Staphylococcus aureus and Streptococcus pyogenes are significant human pathogens, causing infections at multiple body sites, including across the skin. Both are organisms that cause human diseases and secrete superantigens, including toxic shock syndrome
Patrick M. Schlievert +3 more
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Lack of evidence for superantigen activity of Toxoplasma gondii towards human T cells
Brazilian Journal of Medical and Biological Research, 2001 Toxoplasma gondii is an obligatory intracellular parasite whose life cycle may include man as an intermediate host. More than 500 million people are infected with this parasite worldwide. It has been previously reported that T.
A.L. Vallochi +8 more
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