Results 11 to 20 of about 10,170 (163)
Pathogens, 2022 It has been posited SARS-CoV-2 contains at least one unique superantigen-like motif not found in any other SARS or endemic coronaviruses. Superantigens are potent antigens that can send the immune system into overdrive.
Adam Hamdy, Anthony Leonardi
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Binding of superantigen toxins into the CD28 homodimer interface is essential for induction of cytokine genes that mediate lethal shock. [PDF]
PLoS Biology, 2011 Bacterial superantigens, a diverse family of toxins, induce an inflammatory cytokine storm that can lead to lethal shock. CD28 is a homodimer expressed on T cells that functions as the principal costimulatory ligand in the immune response through an ...
Gila Arad +9 more
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Frontiers in Microbiology, 2022 Enterotoxins (SEs) produced by Staphylococcus aureus are the cause of serious food intoxications. Staphylococcal enterotoxin C (SEC) is one of the main contributors, as it is often highly expressed. S. aureus possesses a competitive growth advantage over
Danai Etter +5 more
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Experimental Dermatology, 1996 Abstract Superantigens are potent modulators of the immune system. Some of their biological and immunological properties are reviewed here with special attention to their potential significance for cutaneous inflammation, specific skin immune responses and skin diseases.
J, Saloga, E W, Gelfand, J, Knop
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Antigen-specific downregulation of miR-150 in CD4 T cells promotes cell survival
Frontiers in Immunology, 2023 MicroRNA-150 (miR-150) has been shown to play a general role in the immune system, but very little is known about its role on CD4+ T cell responses. During T cell responses against superantigen Staphylococcal Enterotoxin A, miR-150 expression was down ...
Antoine Ménoret +5 more
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陆军军医大学学报, 2023 As of November 2022, 22 countries in Europe have reported 572 cases of severe acute hepatitis in children with unknown causes. The most common pathogens tested are human adenovirus and SARS-CoV-2. Therefore, the researchers have proposed hypotheses about
DENG Guohong, SHI Tuo
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Frontiers in Immunology, 2022 Multisystem inflammatory syndrome in children (MIS-C) is a febrile pediatric inflammatory disease that may develop weeks after initial SARS-CoV-2 infection or exposure.
Magali Noval Rivas +8 more
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Generation of Novel Tumour-Selective SEA Superantigen-Based Peptides with Improved Safety and Efficacy for Precision Cancer Immunotherapy [PDF]
International Journal of Molecular SciencesSara Bashraheel +2 more
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T cell activation or tolerization: the Yin and Yang of bacterial superantigens
Frontiers in Microbiology, 2015 Bacterial superantigens are exotoxins from pathogens which interact with innate and adaptive immune cells. The paradox that superantigens cause activation and inactivation/anergy of T-cells was soon recognized.
Aline eSähr +3 more
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Frontiers in Immunology, 2023 Life-threatening toxic shock syndrome is often caused by the superantigen toxic shock syndrome toxin-1 (TSST-1) produced by Staphylococcus aureus. A well-known risk factor is the lack of neutralizing antibodies.
Stefan Weiss +24 more
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