Results 11 to 20 of about 10,720 (171)

Superantigens in Cancer Immunotherapy: Mechanisms, Engineering Strategies, and Therapeutic Potential [PDF]

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
Schematic overview of superantigen‐mediated antitumor immune responses and immune suppression within the tumor microenvironment. (1) Antigen‐presenting cells activate T cells through MHC‐II/TCR interactions resulting in the production of cytokines (2) The pro‐inflammatory cytokines released by activated immune cells stimulate downstream immune ...
Urooj Yousaf Virk, Hafiza Aasia Malik, Muneera Anwer, Jennifer Wilson, Md. Sifat Rahi, Ming Q. Wei   +5 more
wiley   +2 more sources

Selective Expansion of TCR Vβ2+ Tregs and Impaired Lymphocyte TSST‐1 Responsiveness in Bullous Pemphigoid Patients Colonised by Staphylococcus aureus [PDF]

Experimental Dermatology, Volume 35, Issue 9, September 2026.
ABSTRACT Bullous pemphigoid (BP) is an autoimmune blistering disease of the elderly who are frequently colonised by Staphylococcus aureus, particularly strains producing the superantigen toxic shock syndrome toxin‐1 (TSST‐1). Given the ability of TSST‐1 to engage the T cell receptor (TCR) Vβ2 chain, we investigated whether superantigen (SAg) exposure ...
Tian Y. Chen, Tyler P. Crowe, Maryam Fakhimi, Mia Poleksíc, Samuel H. Kilgore, Patrick M. Schlievert, Janet A. Fairley, Kelly N. Messingham   +7 more
wiley   +2 more sources

Acquisition of toxin-encoding lysogenic bacteriophage elements enhances the virulence of pandemic Streptococcus pyogenes M1UK [PDF]

Infection and Immunity
Multiple countries have observed an alarming increase in scarlet fever cases, and invasive infections often associated with a new sublineage of Streptococcus pyogenes known as M1UK.
Juan Manuel Díaz, Jasmine E. J. Wells, Amanda C. Marple, Blake A. Shannon, Aanchal Rishi, Irene Martin, Allison McGeer, Matthew A. Croxen, Gregory J. Tyrrell, Mark J. Walker, Stephan Brouwer, John K. McCormick   +11 more
doaj   +2 more sources

Proinflammatory synergy between protease and superantigen streptococcal pyogenic exotoxins [PDF]

Infection and Immunity
Streptococcal pyogenic exotoxins (Spe proteins) secreted by Streptococcus pyogenes (group A Streptococcus, GAS) are responsible for scarlet fever and streptococcal toxic shock syndrome.
Anders F. Johnson, Summer D. Bushman, Doris L. LaRock, Juan Manuel Díaz, John K. McCormick, Christopher N. LaRock   +5 more
doaj   +2 more sources

Outbreak of severe acute hepatitis of unknown cause in children in 2022: analysis of plausible pathogenic mechanism

陆军军医大学学报, 2023
As of November 2022, 22 countries in Europe have reported 572 cases of severe acute hepatitis in children with unknown causes. The most common pathogens tested are human adenovirus and SARS-CoV-2. Therefore, the researchers have proposed hypotheses about
DENG Guohong, SHI Tuo
doaj   +1 more source

Multisystem Inflammatory Syndrome in Children and Long COVID: The SARS-CoV-2 Viral Superantigen Hypothesis

Frontiers in Immunology, 2022
Multisystem inflammatory syndrome in children (MIS-C) is a febrile pediatric inflammatory disease that may develop weeks after initial SARS-CoV-2 infection or exposure.
Magali Noval Rivas, Magali Noval Rivas, Rebecca A. Porritt, Rebecca A. Porritt, Mary Hongying Cheng, Ivet Bahar, Moshe Arditi, Moshe Arditi, Moshe Arditi   +8 more
doaj   +1 more source

T cell activation or tolerization: the Yin and Yang of bacterial superantigens

Frontiers in Microbiology, 2015
Bacterial superantigens are exotoxins from pathogens which interact with innate and adaptive immune cells. The paradox that superantigens cause activation and inactivation/anergy of T-cells was soon recognized.
Aline eSähr, Sandra eFörmer, Dagmar eHildebrand, Klaus eHeeg   +3 more
doaj   +1 more source

Toxin exposure and HLA alleles determine serum antibody binding to toxic shock syndrome toxin 1 (TSST-1) of Staphylococcus aureus

Frontiers in Immunology, 2023
Life-threatening toxic shock syndrome is often caused by the superantigen toxic shock syndrome toxin-1 (TSST-1) produced by Staphylococcus aureus. A well-known risk factor is the lack of neutralizing antibodies.
Stefan Weiss, Stefan Weiss, Silva Holtfreter, Tanja C. Meyer, Frieder Schmiedeke, Clemens Cammann, Marcus Dörr, Marcus Dörr, Stephan B. Felix, Stephan B. Felix, Hans J. Grabe, Georg Homuth, Christian Kohler, Cedric Mahncke, Stephan Michalik, Matthias Nauck, Matthias Nauck, Nele Friedrich, Nele Friedrich, Stefanie Samietz, Henry Völzke, Henry Völzke, Uwe Völker, Uwe Völker, Barbara M. Bröker   +24 more
doaj   +1 more source

Interactions between staphylococcal enterotoxins A and D and superantigen-like proteins 1 and 5 for predicting methicillin and multidrug resistance profiles among Staphylococcus aureus ocular isolates.

PLoS ONE, 2021
BackgroundMethicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant (MDR) S. aureus strains are well recognized as posing substantial problems in treating ocular infections. S.
Min Lu, Jean-Marie Parel, Darlene Miller
doaj   +1 more source

Superantigens, superantigen-like proteins and superantigen derivatives for cancer treatment.

European review for medical and pharmacological sciences, 2021
Bacterial superantigens (SAgs) are proteins produced by few types of bacteria that have been linked to several human diseases. Due to their potent in vitro and in vivo tumoricidal effects, they are extensively investigated for oncological applications either alone or in combination with classical anticancer drugs.
openaire   +2 more sources