Results 11 to 20 of about 12,609 (207)

Abrin Toxin Paradoxically Increases Protein Synthesis in Stimulated CD4⁺ T-Cells While Decreasing Protein Synthesis in Kidney Cells [PDF]

Current Issues in Molecular Biology
Abrin, a toxin of the rosary pea plant (Abras precatorius), has been implicated as causing an autoimmune demyelinating disease in humans, but the exact mechanisms responsible for the induction of these demyelinating conditions are still unknown.
Bradley Hernlem, Reuven Rasooly
doaj   +2 more sources

Role of Infectious Agents in the Etiology of Kawasaki Disease [PDF]

Pediatric Infectious Disease, 2022
Kawasaki disease (KD) is a multisystemic childhood vasculitis that predominantly affects the coronary arteries. The constellation of clinical features in KD, such as, acute onset of fever, redness of lips and oral mucosa, rash, swelling over palms and ...
Aaqib Banday, Pandiarajan Vignesh, Surjit Singh   +2 more
doaj   +1 more source

A recombinant protein containing influenza viral conserved epitopes and superantigen induces broad-spectrum protection

eLife, 2021
Influenza pandemics pose public health threats annually for lacking vaccine that provides cross-protection against novel and emerging influenza viruses.
Yansheng Li, Mingkai Xu, Yongqiang Li, Wu Gu, Gulinare Halimu, Yuqi Li, Zhichun Zhang, Libao Zhou, Hui Liao, Songyuan Yao, Huiwen Zhang, Chenggang Zhang   +11 more
doaj   +1 more source

Superantigens and SARS-CoV-2

Pathogens, 2022
It has been posited SARS-CoV-2 contains at least one unique superantigen-like motif not found in any other SARS or endemic coronaviruses. Superantigens are potent antigens that can send the immune system into overdrive.
Adam Hamdy, Anthony Leonardi
doaj   +1 more source

Mild NaCl Stress Influences Staphylococcal Enterotoxin C Transcription in a Time-Dependent Manner and Reduces Protein Expression

Frontiers in Microbiology, 2022
Enterotoxins (SEs) produced by Staphylococcus aureus are the cause of serious food intoxications. Staphylococcal enterotoxin C (SEC) is one of the main contributors, as it is often highly expressed. S. aureus possesses a competitive growth advantage over
Danai Etter, Danai Etter, Christina Ukowitz, Corinne Eicher, Taurai Tasara, Sophia Johler   +5 more
doaj   +1 more source

Antigen-specific downregulation of miR-150 in CD4 T cells promotes cell survival

Frontiers in Immunology, 2023
MicroRNA-150 (miR-150) has been shown to play a general role in the immune system, but very little is known about its role on CD4+ T cell responses. During T cell responses against superantigen Staphylococcal Enterotoxin A, miR-150 expression was down ...
Antoine Ménoret, Federica Agliano, Timofey A. Karginov, Keaton S. Karlinsey, Beiyan Zhou, Anthony T. Vella   +5 more
doaj   +1 more source

Superantigens [PDF]

Experimental Dermatology, 1996
Abstract Superantigens are potent modulators of the immune system. Some of their biological and immunological properties are reviewed here with special attention to their potential significance for cutaneous inflammation, specific skin immune responses and skin diseases.
J, Saloga, E W, Gelfand, J, Knop
openaire   +2 more sources

Outbreak of severe acute hepatitis of unknown cause in children in 2022: analysis of plausible pathogenic mechanism

陆军军医大学学报, 2023
As of November 2022, 22 countries in Europe have reported 572 cases of severe acute hepatitis in children with unknown causes. The most common pathogens tested are human adenovirus and SARS-CoV-2. Therefore, the researchers have proposed hypotheses about
DENG Guohong, SHI Tuo
doaj   +1 more source

Multisystem Inflammatory Syndrome in Children and Long COVID: The SARS-CoV-2 Viral Superantigen Hypothesis

Frontiers in Immunology, 2022
Multisystem inflammatory syndrome in children (MIS-C) is a febrile pediatric inflammatory disease that may develop weeks after initial SARS-CoV-2 infection or exposure.
Magali Noval Rivas, Magali Noval Rivas, Rebecca A. Porritt, Rebecca A. Porritt, Mary Hongying Cheng, Ivet Bahar, Moshe Arditi, Moshe Arditi, Moshe Arditi   +8 more
doaj   +1 more source

Superantigenic Activity of emm3 Streptococcus pyogenes Is Abrogated by a Conserved, Naturally Occurring smeZ Mutation [PDF]

, 2012
Streptococcus pyogenes M/emm3 strains have been epidemiologically linked with enhanced infection severity and risk of streptococcal toxic shock syndrome (STSS), a syndrome triggered by superantigenic stimulation of T cells. Comparison of S.
McGregor, Karen, Davies, F.J., Frances J Davies, Chong, Deborah L. W., McGregor, K., Davies, Frances J., McGregor, K, Leili Farzaneh, Spratt, BG, Leili Farzaneh (130255), Pichon, B., Shiranee Sriskandan, Efstratiou, A, McGregor Karen, Bruno Pichon (130249), Pichon, B, Holden, Matthew T. G., Davies, FJ, Mary Sommerlad, Androulla Efstratiou, Turner, CE, Sommerlad, M, Chong, DLW, Sriskandan Shiranee, Mary Sommerlad (130242), Sommerlad, M., Turner Claire E., Farzaneh, L., Brian G Spratt, Deborah L. W. Chong (130252), Brian G. Spratt (10001), Sriskandan, Shiranee, Holden, M.T., Holden, MTG, Matthew T G Holden, Sriskandan, S., Androulla Efstratiou (130260), Sommerlad Mary, Matthew T. G. Holden (130258), Pichon Bruno, Frances J. Davies (130247), Spratt, B.G., Shiranee Sriskandan (16154), Holden Matthew T. G., Karen McGregor (130245), Chong Deborah L. W., Turner, C.E., Karen McGregor, Sommerlad, Mary, Farzaneh, L, Sriskandan, S, Claire E Turner, Davies Frances J., Pichon, Bruno, Efstratiou, A., Farzaneh, Leili, Spratt Brian G., Claire E. Turner (130239), Spratt, Brian G., Efstratiou, Androulla, Efstratiou Androulla, Chong, D.L., Deborah L W Chong, Bruno Pichon, Farzaneh Leili, Turner, Claire E.   +65 more
core   +1 more source