Results 51 to 60 of about 12,609 (207)

Genomic analysis and identification of a novel superantigen, SargEY, in Staphylococcus argenteus isolated from atopic dermatitis lesions

mSphere
During surveillance of Staphylococcus aureus in lesions from patients with atopic dermatitis (AD), we isolated Staphylococcus argenteus, a species registered in 2011 as a new member of the genus Staphylococcus and previously considered a lineage of S ...
Fatkhanuddin Aziz, Junzo Hisatsune, Hisaya K. Ono, Junko Kajimura, Liansheng Yu, Kanako Masuda, Hiroki Kitagawa, Yusuke Sato'o, Koji Yahara, Mika Yamaoka, Akio Nakane, Hiroshi Kawasaki, Shoko Obata, Ayano Fukushima-Nomura, Yoshihiro Ito, Meiji Soe Aung, Masayuki Amagai, Siti Isrina Oktavia Salasia, Hiroki Ohge, Yoichiro Kusunoki, Motoyuki Sugai   +20 more
doaj   +1 more source

Bacterial superantigen facilitates epithelial presentation of allergen to T helper 2 cells

, 2007
Although clinical and laboratory evidence support roles for both staphylococcal infection and environmental allergens in the pathogenesis of atopic dermatitis, human studies have largely considered these variables independently.
Ardern-Jones, Michael R., Bateman, Elizabeth A., Ogg, Graham S., Black, Antony P.   +3 more
core   +1 more source

The Systemic and Pulmonary Immune Response to Staphylococcal Enterotoxins

Toxins, 2010
In response to environmental cues the human pathogen Staphylococcus aureus synthesizes and releases proteinaceous enterotoxins. These enterotoxins are natural etiologic entities of severe food poisoning, toxic shock syndrome, and acute diseases ...
Anthony T. Vella, Sanjeev Kumar, Soo-Mun Ngoi, Antoine Ménoret   +3 more
doaj   +1 more source

Human scFvs That Counteract Bioactivities of Staphylococcus aureus TSST-1

Toxins, 2017
Some Staphylococcus aureus isolates produced toxic shock syndrome toxin-1 (TSST-1) which is a pyrogenic toxin superantigen (PTSAg). The toxin activates a large fraction of peripheral blood T lymphocytes causing the cells to proliferate and release ...
Thunchanok Rukkawattanakul, Nitat Sookrung, Watee Seesuay, Nattawat Onlamoon, Pornphan Diraphat, Wanpen Chaicumpa, Nitaya Indrawattana   +6 more
doaj   +1 more source

Elucidating the Staphylococcus aureus TSST‐1 Regulatory Network as a Response to Vaginal pH

Molecular Microbiology, EarlyView.
Toxic shock syndrome toxin‐1 (TSST‐1) is a potent Staphylococcus aureus superantigen responsible for menstrual toxic shock syndrome (mTSS). Regulation of TSST‐1 is controlled by multiple systems including the stand‐alone transcriptional regulators CcpA and SarA and two‐component systems including the redox sensor SrrAB, the membrane stress sensor SaeRS,
Carla S. Maduta, Nicholas R. Walton, Emily P. Barbosa, Erica N. DeJong, Karine Dufresne, John K. McCormick   +5 more
wiley   +1 more source

Staphylococcal Enterotoxin C Is an Important Virulence Factor for Mastitis

Toxins, 2019
Staphylococcus aureus is an important bacterial pathogen causing bovine mastitis, but little is known about the virulence factor and the inflammatory responses in the mammary infection.
Rendong Fang, Jingchun Cui, Tengteng Cui, Haiyong Guo, Hisaya K. Ono, Chun-Ho Park, Masashi Okamura, Akio Nakane, Dong-Liang Hu   +8 more
doaj   +1 more source

Lymphocyte Redox Imbalance and Reduced Proliferation after a Single Session of High Intensity Interval Exercise. [PDF]

PLoS ONE, 2016
This study investigated whether an acute session of high-intensity interval training (HIIT) is sufficient to alter lymphocyte function and redox status. Sixteen young healthy men underwent a HIIT session on a cycloergometer, consisting of eight bouts of ...
Rosalina Tossige-Gomes, Karine Beatriz Costa, Vinícius de Oliveira Ottone, Flávio de Castro Magalhães, Fabiano Trigueiro Amorim, Etel Rocha-Vieira   +5 more
doaj   +1 more source

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source

Lack of improvement after short‐term topical antistaphylococcal endolysin SA.100 therapy in patients with mild‐to‐moderate atopic dermatitis: Results from a randomized, vehicle‐controlled trial

British Journal of Clinical Pharmacology, Volume 92, Issue 7, Page 2409-2413, July 2026.
Abstract Atopic dermatitis (AD) is a chronic immune‐mediated inflammatory skin disease. An overgrowth of Staphylococcus aureus (S. aureus) and decreased microbial diversity is apparent in 70%–90% of AD patients. SA.100 is a recombinant endolysin targeting S. aureus that might be a novel treatment for patients with mild‐to‐moderate AD.
Laura W. J. van der Meulen, Menthe E. Bergmans, Salma Assil, Ismahaan Abdisalaam, Rianne Rijneveld, Erica S. Klaassen, Alexa J. Tibboel, Thorsten Brach, Bjorn L. Herpers, Johan Frieling, Benthe Freyee, Karin Platenkamp, Mariette E. van Poelgeest, Robert Rissmann, Martijn B. A. van Doorn, Tessa Niemeyer – van der Kolk   +15 more
wiley   +1 more source

Transcytosis, Antitumor Activity and Toxicity of Staphylococcal Enterotoxin C2 as an Oral Administration Protein Drug

Toxins, 2016
Staphylococcal enterotoxin C2 (SEC2) is a classical superantigen (SAg), which can tremendously activate T lymphocytes at very low dosage, thus exerting its powerful antitumor activity.
Wenbin Zhao, Yangyang Li, Wenhui Liu, Ding Ding, Yingchun Xu, Liqiang Pan, Shuqing Chen   +6 more
doaj   +1 more source