Results 1 to 10 of about 5,849 (122)

Toxin exposure and HLA alleles determine serum antibody binding to toxic shock syndrome toxin 1 (TSST-1) of Staphylococcus aureus [PDF]

Frontiers in Immunology, 2023
Life-threatening toxic shock syndrome is often caused by the superantigen toxic shock syndrome toxin-1 (TSST-1) produced by Staphylococcus aureus. A well-known risk factor is the lack of neutralizing antibodies.
Silva Holtfreter, Clemens Cammann, Stephan Michalik   +2 more
exaly   +4 more sources

TSST-1 promotes colonization of Staphylococcus aureus within the vaginal tract by activation of CD8 + T cells [PDF]

Infection and Immunity
Toxic shock syndrome toxin-1 (TSST-1) is a superantigen produced by Staphylococcus aureus and is the determinant of menstrual toxic shock syndrome (mTSS); however, the impact of TSST-1 on the vaginal environment beyond mTSS is not understood.
Karine Dufresne, Heather C Craig, Jeremy P Burton   +2 more
exaly   +4 more sources

Human scFvs That Counteract Bioactivities of Staphylococcus aureus TSST-1 [PDF]

Toxins, 2017
Some Staphylococcus aureus isolates produced toxic shock syndrome toxin-1 (TSST-1) which is a pyrogenic toxin superantigen (PTSAg). The toxin activates a large fraction of peripheral blood T lymphocytes causing the cells to proliferate and release ...
Nitat Sookrung, Watee Seesuay, Nattawat Onlamoon   +2 more
exaly   +4 more sources

Identification of a novel fully human anti-toxic shock syndrome toxin (TSST)-1 single-chain variable fragment antibody averting TSST-1-induced mitogenesis and cytokine secretion [PDF]

BMC Biotechnology, 2022
Background Staphylococcal superantigens are virulence factors that help the pathogen escape the immune system and develop an infection. Toxic shock syndrome toxin (TSST)-1 is one of the most studied superantigens whose role in toxic shock syndrome and ...
Mahdieh Soezi, Somayeh Piri-Gavgani, Mostafa Ghanei, Mir Davood Omrani, Behnoush Soltanmohammadi, Kamran Pooshang Bagheri, Reza Ahangari Cohan, Farzam Vaziri, Seyed Davar Siadat, Abolfazl Fateh, Shohreh Khatami, Masoumeh Azizi, Fatemeh Rahimi-Jamnani   +12 more
doaj   +2 more sources

Toxic Shock Syndrome Toxin-1 (TSST-1) in Staphylococcus aureus: Prevalence, Molecular Mechanisms, and Public Health Implications [PDF]

Toxins
Staphylococcus aureus is a significant pathogen responsible for various infections, with its production of toxic shock syndrome toxin-1 (TSST-1) being a central factor in the pathogenesis of toxic shock syndrome (TSS).
Rahima Touaitia, Nasir Adam Ibrahim, Eman Abdullah Almuqri, Nosiba S. Basher, Takfarinas Idres, Abdelaziz Touati   +5 more
doaj   +2 more sources

Occurrence of Staphylococcus aureus TSST-1 in Foods: A Review [PDF]

Toxins
Toxic Shock Syndrome Toxin-1 (TSST-1) is produced by Staphylococcus aureus strains encoded by the tst gene. Toxic shock syndrome (TSS) is a severe disease caused by TSST-1 toxin and associated with staphylococcal food poisoning (SFP).
Maria Govari, Andreana Pexara
doaj   +2 more sources

Staphylococcal TSST-1 Association with Eczema Herpeticum in Humans [PDF]

mSphere, 2021
Atopic dermatitis (eczema, AD) with concurrent herpes simplex virus infection (eczema herpeticum, ADEH) is a severe form of AD.
Patrick M. Schlievert, Richard J. Roller, Samuel H. Kilgore, Miguel Villarreal, Aloysius J. Klingelhutz, Donald Y. M. Leung   +5 more
doaj   +2 more sources

Candida albicans promotes TSST-1 production by Staphylococcus aureus through glucose depletion and relief of CcpA-mediated repression [PDF]

Journal of Bacteriology
Menstrual toxic shock syndrome (mTSS) is a rare yet life-threatening disease that is caused when the opportunistic pathogenic bacterium Staphylococcus aureus releases the toxic shock syndrome toxin 1 (TSST-1) superantigen, which triggers systemic ...
Mathias Carriou, Cédric Badiou, Alexandre Soulard, Christophe d'Enfert, Karine Dufresne, Gérard Lina   +5 more
doaj   +2 more sources

Does Aerobic Capacity Protect Against Stress? Insights From Two Stress-Induction Paradigms. [PDF]

Psychophysiology
ABSTRACT Prior evidence suggests that individuals with higher fitness exhibit attenuated endocrine and autonomic responses to acute psychological and physical stressors. However, it remains unclear whether this stress‐buffering effect depends on the type of stressor.
Raidl P, Vogl A, Dreisörner A, Wessner B, Nater UM, Csapo R.   +5 more
europepmc   +2 more sources

Psychological stress catalyses free radical-mediated activation of coagulation in humans. [PDF]

J Physiol
Abstract figure legend This study provides the first in vivo evidence that acute psychological stress triggers systemic free radical formation and prothrombotic remodelling of blood clot microstructure. By inducing stress in healthy participants, we observed a significant increase in oxidative stress (A•−), a shortening of the intrinsic pathway of ...
Fall L, Stacey BS, Swain E, Samuel E, Robinson M, Walmsley DW, Marley CJ, Owens TS, Haq A, Yandle LG, Cox K, Bailey DM.   +11 more
europepmc   +2 more sources