Human scFvs That Counteract Bioactivities of Staphylococcus aureus TSST-1 [PDF]
Toxins, 2017 Some Staphylococcus aureus isolates produced toxic shock syndrome toxin-1 (TSST-1) which is a pyrogenic toxin superantigen (PTSAg). The toxin activates a large fraction of peripheral blood T lymphocytes causing the cells to proliferate and release ...
Nitat Sookrung +2 more
exaly +8 more sources
Identification of a novel fully human anti-toxic shock syndrome toxin (TSST)-1 single-chain variable fragment antibody averting TSST-1-induced mitogenesis and cytokine secretion [PDF]
BMC Biotechnology, 2022 Background Staphylococcal superantigens are virulence factors that help the pathogen escape the immune system and develop an infection. Toxic shock syndrome toxin (TSST)-1 is one of the most studied superantigens whose role in toxic shock syndrome and ...
Mahdieh Soezi +12 more
doaj +9 more sources
Toxin exposure and HLA alleles determine serum antibody binding to toxic shock syndrome toxin 1 (TSST-1) of Staphylococcus aureus [PDF]
Frontiers in Immunology, 2023 Life-threatening toxic shock syndrome is often caused by the superantigen toxic shock syndrome toxin-1 (TSST-1) produced by Staphylococcus aureus. A well-known risk factor is the lack of neutralizing antibodies.
Tanja C Meyer +2 more
exaly +5 more sources
Staphylococcal TSST-1 Association with Eczema Herpeticum in Humans [PDF]
mSphere, 2021 Atopic dermatitis (eczema, AD) with concurrent herpes simplex virus infection (eczema herpeticum, ADEH) is a severe form of AD.
Patrick M. Schlievert +5 more
doaj +5 more sources
TSST-1 protein exerts indirect effect on platelet activation and apoptosis
Platelets, 2022 Thrombocytopenia or platelet dysfunction is a risk factor for severe infection. Staphylococcus aureus (S. aureus) releases a variety of virulence factors especially toxic shock syndrome toxin 1 (TSST-1), which may cause toxic shock syndrome. S.
Min Guo +6 more
exaly +5 more sources
Toxic Shock Syndrome Toxin-1 (TSST-1) in Staphylococcus aureus: Prevalence, Molecular Mechanisms, and Public Health Implications [PDF]
ToxinsStaphylococcus aureus is a significant pathogen responsible for various infections, with its production of toxic shock syndrome toxin-1 (TSST-1) being a central factor in the pathogenesis of toxic shock syndrome (TSS).
Rahima Touaitia +5 more
doaj +3 more sources
The superantigens SpeC and TSST-1 specifically activate TRBV12-3/12-4+ memory T cells. [PDF]
Commun Biol, 2023 Severe bacterial or viral infections can induce a state of immune hyperactivation that can culminate in a potentially lethal cytokine storm. The classic example is toxic shock syndrome, a life-threatening complication of Staphylococcus aureus or ...
Shepherd FR +9 more
europepmc +6 more sources
Occurrence of Staphylococcus aureus TSST-1 in Foods: A Review [PDF]
ToxinsToxic Shock Syndrome Toxin-1 (TSST-1) is produced by Staphylococcus aureus strains encoded by the tst gene. Toxic shock syndrome (TSS) is a severe disease caused by TSST-1 toxin and associated with staphylococcal food poisoning (SFP).
Maria Govari, Andreana Pexara
doaj +3 more sources
TSST-1 promotes colonization of Staphylococcus aureus within the vaginal tract by activation of CD8+ T cells [PDF]
Infection and ImmunityToxic shock syndrome toxin-1 (TSST-1) is a superantigen produced by Staphylococcus aureus and is the determinant of menstrual toxic shock syndrome (mTSS); however, the impact of TSST-1 on the vaginal environment beyond mTSS is not understood.
Karine Dufresne +6 more
doaj +3 more sources
Vaginal community state types (CSTs) alter environmental cues and production of the Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1). [PDF]
J Bacteriol, 2023 Menstrual toxic shock syndrome (mTSS) is a rare but life-threatening disease associated with the use of high-absorbency tampons. The production of the Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1) superantigen is involved in nearly all ...
Maduta CS, McCormick JK, Dufresne K.
europepmc +2 more sources