Results 31 to 40 of about 5,899 (161)

Structural basis of T‐cell specificity and activation by the bacterial superantigen TSST‐1 [PDF]

The EMBO Journal, 2007
Superantigens (SAGs) bind simultaneously to major histocompatibility complex (MHC) and T-cell receptor (TCR) molecules, resulting in the massive release of inflammatory cytokines that can lead to toxic shock syndrome (TSS) and death. A major causative agent of TSS is toxic shock syndrome toxin-1 (TSST-1), which is unique relative to other bacterial ...
Beenu, Moza, Ashok K, Varma, Rebecca A, Buonpane, Penny, Zhu, Christine A, Herfst, Melissa J, Nicholson, Anne-Kathrin, Wilbuer, Nilufer P, Seth, Kai W, Wucherpfennig, John K, McCormick, David M, Kranz, Eric J, Sundberg   +11 more
openaire   +2 more sources

Shocking! The Effect of TSST‐1 in Toxic Shock Syndrome

The FASEB Journal, 2019
Almost 20% of children who die of Sudden Infant Death Syndrome have a protein called Toxic Shock Syndrome Toxin‐1 (TSST‐1), produced by Staphylococcus aureus. This protein is also responsible for toxic shock and food poisoning. S. aureus produces this superantigen TSST‐1 to divert the immune system and multiply rapidly inside the body.
Mark Arnholt, Diane H Munzenmaier, Evelyn Anderson, Cassidy Benson, Julia Brown, Margaret Colwell, Theodore Colwell, Michael Flanagan, Lauren Hautala, Delaney Hennes, Gabriel Hoffmann, Cara Kennedy, Leah Lisowski, Tate Stoeckmann, Emma Witt, Rachel Zuern   +15 more
openaire   +1 more source

Modulatory Effects of Staphylococcal Superantigen TSST-1 on IGE Synthesis in Atopic Dermatitis [PDF]

Clinical Immunology and Immunopathology, 1995
Atopic dermatitis (AD) is a chronic skin disorder associated with elevated serum IgE and colonization of the skin by Staphylococi which secrete toxins with superantigenic activity. The present study examined the immunomodulatory effects of toxic shock syndrome toxin (TSST)-1, a prototypic superantigen, on IgE synthesis by interleukin (IL)-4-stimulated ...
M R, Lester, M F, Hofer, H, Renz, A E, Trumble, E W, Gelfand, D Y, Leung   +5 more
openaire   +3 more sources

Staphylococcal Superantigens Stimulate Epithelial Cells through CD40 To Produce Chemokines

mBio, 2019
Mucosal and skin tissues form barriers to infection by most bacterial pathogens. Staphylococcus aureus causes diseases across these barriers in part dependent on the proinflammatory properties of superantigens.
Patrick M. Schlievert, Michael P. Cahill, Bruce S. Hostager, Amanda J. Brosnahan, Aloysius J. Klingelhutz, Francoise A. Gourronc, Gail A. Bishop, Donald Y. M. Leung   +7 more
doaj   +1 more source

Variations in amount of TSST-1 produced by clinical methicillin resistant Staphylococcus aureus (MRSA) isolates and allelic variation in accessory gene regulator (agr) locus

BMC Microbiology, 2009
Background Staphylococcus aureus (S. aureus) is an important pathogen associated with both nosocomial and community-acquired infections and its pathogenicity is attributed to its potential to produce virulence factors.
Hasegawa Yoshinori, Hasegawa Tadao, Yamada Keiko, Okamoto Akira, Nagao Miki, Ohta Michio   +5 more
doaj   +1 more source

Association of tsst-1 and pvl with mecA Genes among Clinical Staphylococcus aureus Isolates from a Tertiary Care Hospital

Journal of Pure and Applied Microbiology, 2019
To investigate the association of both tsst-1 and pvl with mecA genes in clinical Staphylococcus aureus (S. aureus) strains obtained from a tertiary care hospital, Mansoura-Egypt.
Amira M. Sultan, Yasmin Nabiel
doaj   +1 more source

Detection of Toxic Shock Syndrome Toxin-1 among Children Undergoing Surgical Operations

مجلة كلية الطب, 2017
Background: Toxic-shock syndrome (TSS) is an acute onset; multiorgan disease caused mainly by Toxic-shock syndrome toxin-1 (TSST-1) producing Staphylococcus aureus strains.Testing for TSST-1 or anti-TSST-1 antibodies in the clinical setting may help to ...
Abdul-Razak Sh. Hasan, Asmaa H. Hwaid, Zainab H. Mahdy   +2 more
doaj   +1 more source

Comparison of Transcriptional Signatures of Three Staphylococcal Superantigenic Toxins in Human Melanocytes

Biomedicines, 2022
Staphylococcus aureus, a gram-positive bacterium, causes toxic shock through the production of superantigenic toxins (sAgs) known as Staphylococcal enterotoxins (SE), serotypes A-J (SEA, SEB, etc.), and toxic shock syndrome toxin-1 (TSST-1).
Nabarun Chakraborty, Seshamalini Srinivasan, Ruoting Yang, Stacy-Ann Miller, Aarti Gautam, Leanne J. Detwiler, Bonnie C. Carney, Abdulnaser Alkhalil, Lauren T. Moffatt, Marti Jett, Jeffrey W. Shupp, Rasha Hammamieh   +11 more
doaj   +1 more source

شناسایی ژن مولد توکسین-1 سندروم شوک توکسیک (TSST-1) در جدایه‌های استافیلوکوکوس ارئوس‌های جمع‌آوری شده از نمونه‌های شیرتورم پستان گاو [PDF]

Archives of Razi Institute, 2013
استافیلوکوکوس ارئوس یکی از مهمترین عوامل ایجاد کننده تورم پستان بالینی و تحت بالینی در دام‌های شیری می‌باشد. این باکتری طیف وسیعی از توکسین‌های خارج سلولی و فاکتورهای حدت (TSST-1) تولید می‌کند که در بیماری‌زایی آن نقش دارد.
ح. دستمالچی ساعی, مهدی احمدی, س. فرحمند آذر, احسان عناصری   +3 more
doaj   +1 more source

Extrinsic and Intrinsic Charge Transfer at Interfaces of Membrane‐Based Oxide Heterostructures

Advanced Electronic Materials, EarlyView.
Freestanding oxides have emerged as a new opportunity to tailor oxides outside of the typical epitaxial constraints. We present the fabrication of TiO2‐terminated SrTiO3 membranes via direct growth control. We demonstrate competing ionic and electronic charge transfer in LaAlO3/SrTiO3 bilayers using near ambient pressure XPS.
Kapil Nayak, Marcus A. Wohlgemuth, Anton Kaus, Lisa Heymann, Alexandros Sarantopoulos, Lee‐Kang Huang, Christoph Baeumer, Regina Dittmann, Felix Gunkel   +8 more
wiley   +1 more source