Results 131 to 140 of about 3,132,425 (322)
, 2001 In this Article we offer one small idea with potentially large implications. We propose the recognition arid development of a special tort for toxic exposures, where the exposures have not yet led to a physical illness such as cancer. We argue, in brief,
Heinzerling, Lisa +1 more
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
The non-selective Antarctic filter feeder Salpa thompsoni as a bioindicator of mercury origin
Scientific ReportsHg is considered as the most toxic metal in the environment. Sources of Hg in the environment include burning fossil fuels, burning waste, and forest fires.
Adriana Wojdasiewicz +2 more
doaj +1 more source
Environmental Chemistry and EcotoxicologyThe ecological and human health risks associated with heavy metal(loid)s (HMs) have attracted much attentions worldwide. In this study, 153 topsoil samples were collected across China in 2019, aiming to investigate the HMs pollution characteristics.
Chang-Yu Weng +3 more
doaj +1 more source
[Preparedness on Assaults with Highly Toxic Substances in Public Space]. [PDF]
Gesundheitswesen, 2022 Socher M, Zilker T, Fromme H, Wildner M.
europepmc +1 more source
Increasing ecological safety during underground mining of iron-ore deposits [PDF]
, 2018 Purpose. To create the technology increasing the level of ecological safety of underground mining of iron ores by means of decreasing the number of harmful substances released into the atmosphere. Methodology. Laboratory and industrial research studies
Khomenko, O.Ye +3 more
core
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Ecotoxicology and Environmental SafetyOverusing chlorpyrifos (CPF) in tropical countries such as Costa Rica poses a potential risk to freshwater ecosystems. This study investigated the effects of transient exposure to an environmentally relevant CPF concentration on the native fish species ...
Daniel Sánchez-González +4 more
doaj +1 more source
Toxic Substances Control Act (TSCA) Implementation: New Ways to Promote Occupational Justice and Prevent Worker Exposures From Hazardous Chemicals. [PDF]
Workplace Health Saf, 2022 Koman PD +3 more
europepmc +1 more source