Results 51 to 60 of about 780,751 (311)

Intravenous Injection of Saeng Maek San - A Safe Method of Treatment in Rats

Journal of Pharmacopuncture, 2014
Objectives:This study evaluated the single-dose toxicity of Saeng Maek San (SMS) in rats. Methods:All experiments were conducted at Biotoxtech (Chungwon, Korea), an institute authorized to perform non-clinical studies under the regulations of Good ...
Seung-Hun Cho, Min-ji Choi, Sung-chul Kim   +2 more
doaj   +1 more source

The multifocal pattern electroretinogram in chloroquine retinopathy [PDF]

, 2004
Purpose: Optimal screening for ocular toxicity caused by chloroquine and hydroxychloroquine is still controversial. With the multifocal pattern electroretinogram (mfPERG), a new electrophysiological technique has recently become available to detect early
Stiefelmeyer, S., Berninger, T., Neubauer, A. S., Arden, G. B., Rudolph, G.   +4 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Hemolytic toxicity test.

, 2019
Hemolytic toxicity test.
Ayumi Sakata (5499740), Akira Saito (244888), Yasunari Miyazaki (664431), Hiroaki Saito (24514), Rie Kurashige (6744104), Hiroki Kageshima (6744107), Daisuke Murakami (6106532), Yumi Sakakibara (4822074)   +7 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Does selenium offset methylmercury toxicity across trophic levels in a primary producer, Auxenochlorella pyrenoidosa, and a detritovore, Aeolosoma variegatum?

FACETS
Methylmercury ([CH3Hg]+ or MeHg) is a potent neurotoxin that impairs functioning of the nervous system, and selenium (Se) is known to provide a protective effect against MeHg.
Husnah Azmi, Stephanie J. Melles, Andrew E. Laursen   +2 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Liver Safety Assessment of an Indonesian Hexavalent Vaccine Candidate Through Histopathology and ALT/AST Evaluation in Rats and Rabbits

Vaccines
Background: Administering several separate childhood vaccines can reduce adherence to immunization schedules due to missed appointments and the burden of repeated injections. A hexavalent formulation targeting diphtheria, tetanus, pertussis, hepatitis B,
Elisa D. Pratiwi, Tiza W. Mawaddah, Arif R. Sadjuri, Dimas T. Nugroho, Arip Hidayat, Astria N. Nidom, Zakiyyan I. Ayyuba, Eka S. Wahyuningsih, Kuncoro P. Santoso, Hani Plumeriastuti, Soeharsono, Setyarina Indrasari, Reviany V. Nidom, Acep R. Wijayadikusumah, Chairul A. Nidom   +14 more
doaj   +1 more source

Review on the acute Daphnia magna toxicity test – Evaluation of the sensitivity and the precision of assays performed with organisms from laboratory cultures or hatched from dormant eggs [PDF]

Knowledge and Management of Aquatic Ecosystems, 2009
One of the most internationally used bioassays for toxicity screening of chemicals and for toxicity monitoring of effluents and contaminated waters is the acute toxicity test with daphnid crustaceans, and in particular that performed with Daphnia magna ...
G. Persoone, R. Baudo, M. Cotman, C. Blaise, K.Cl. Thompson, M. Moreira-Santos, B. Vollat, A. Törökne, T. Han   +8 more
doaj  

Intramuscular Single-dose Toxicity Test of Bufonis venonum Pharmacopuncture in Sprague-Dawley Rats

Journal of Pharmacopuncture, 2015
Objectives: Bufonis venonum (BV) is the dried white secretions of the auricular and skin glands of the toads Bufo bufo gargarizans or Bufo melanosticus Schneider.
Kwang-Ho Lee, Seung-Ho Sun, Jun-Sang Yu, Ki-Rok Kwon   +3 more
doaj   +1 more source