Results 41 to 50 of about 3,927 (153)

Ashwagandha: Is It Safe? Part 2: A Preclinical Evidence Review

Phytotherapy Research, EarlyView.
ABSTRACT The preclinical evidence for the safety of ashwagandha (Withania somnifera (L.) Dunal, AS) is reviewed, and its preparations (extracts) and constituents, from the general toxicity in animal models to in vitro and cell culture studies, which may elucidate mechanisms of action and explain clinical case reports.
Elizabeth M. Williamson, Thomas Brendler
wiley   +1 more source

In Vivo and In Vitro Toxicity Evaluation of Polyprenols Extracted from Ginkgo biloba L. Leaves

Molecules, 2015
Polyprenols of Ginkgo biloba L. leaves (GBP) are a new type of lipid with 14–24 isoprenyl units, which in humans have strong bioactivity like the dolichols.
Cheng-Zhang Wang, Jiao-Jiao Yuan, Wen-Jun Li, Hong-Yu Zhang, Jian-Zhong Ye   +4 more
doaj   +1 more source

Acute and Subchronic Toxicity Studies of Aristolochic Acid A in Tianfu Broilers

Animals, 2021
Aristolochic acid (AA) is one of the components of some traditional Chinese medicines, which has high toxic potential in animals, leading to huge economic losses in the breeding industry.
Dan Xu, Chonglin Ran, Lizi Yin, Juchun Lin, Hualin Fu, Xi Peng, Xiaoling Zhao, Gang Shu   +7 more
doaj   +1 more source

Ecotoxicological Evaluation of Organic Sunscreens Used Worldwide, Alone and in Mixture, on Terrestrial Plants

Environmental Toxicology, EarlyView.
ABSTRACT The environmental hazards of sunscreens are discussed worldwide. However, there are few ecotoxicological studies on these compounds alone for edaphic organisms, and none for their mixtures. Avobenzone (1 and 10 ng/L), octocrylene (10 and 100 μg/L), and oxybenzone (2 and 20 μg/L), alone and in binary combinations (between the lowest and the ...
Diego Espirito Santo, Edson Araújo de Almeida, Elisângela Dusman, A. C. Downs, Regiane da Silva Gonzalez, Osvaldo Valarini Junior, Ana Paula Peron   +6 more
wiley   +1 more source

The Impact of Environmental Pollution and Climate Change on Allergic Rhinitis and Lung Diseases

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Environmental pollution and climate change seriously affect human health, leading to the onset and exacerbation of chronic respiratory diseases, such as allergic rhinitis and lung diseases. Over the past several decades, increasing air pollution and environmental exposure owing to global urbanization, industrialization, and rapid economic ...
Xin‐Yan Liu, Rui‐Ming Han, Yong‐Tai Wang, Dong‐Dong Zhu, Cui‐Da Meng   +4 more
wiley   +1 more source

Subchronic effect of different doses ofDiclofenac Sodium on female reproductive system in rats.

Iraqi Journal of Pharmaceutical Sciences, 2023
 NSAIDs are widely utilized drugs in today's world. These medications are well-known for their anti-inflammatory and analgesic properties. The goal of this study was to suggest and explain the subchronic effects of low and high doses of diclofenac on ...
Bedoor A. Salim, Muhsin S.G. AL-Moziel, Ausama Ayob Jaccob   +2 more
doaj   +1 more source

Targeting Autophagy in Ovarian Cancer: The Emerging Role of Ginsenosides

Cancer Medicine, Volume 15, Issue 3, March 2026.
ABSTRACT Background Ovarian cancer, the third most prevalent gynecological malignancy, is frequently diagnosed at an advanced stage owing to its asymptomatic early progression. Despite the application of conventional therapies, clinical management remains limited by adverse effects and the development of drug resistance.
Yuxin Guo, Cuilan Yun, Yuemei Zhang, Xu Yang, Huiqin Liu   +4 more
wiley   +1 more source

Acute and subchronic dermal toxicity of nanosilver in guinea pig

International Journal of Nanomedicine, 2011
M Korani1, SM Rezayat1,2,4, K Gilani3, S Arbabi Bidgoli4, S Adeli11Department of Pharmacology, Faculty of Medicine, Tehran University of Medical Sciences; 2Department of Nanotechnology, Faculty of Advanced Sciences and Technology in Medicine ...
Arbabi Bidgoli S, Rezayat SM, Gilani K, Adeli S, Korani M   +3 more
doaj  

Safety and efficacy evaluation of halicin as an effective drug for inhibiting intestinal infections

Frontiers in Pharmacology
Halicin, the first antibacterial agent discovered by artificial intelligence, exerts broad-spectrum antibacterial effects and has a unique structure. Our study found that halicin had a good inhibitory effect on clinical isolates of drug-resistant strains
Maolu Zhang, Maolu Zhang, Shuqian Lin, Lianquan Han, Jiaming Zhang, Shaoning Liu, Xiuzhen Yang, Ruiming Wang, Xiaohui Yang, Yunpeng Yi   +9 more
doaj   +1 more source

Non-clinical safety evaluation of salvianolic acid A: acute, 4-week intravenous toxicities and genotoxicity evaluations

BMC Pharmacology and Toxicology, 2022
Background Toxicological problem associated with herbal medicine is a significant public health problem. Hence, it is necessary to elaborate on the safety of herbal medicine.
Ming-Yan Yang, Ze-Yu Song, Hai-Lin Gan, Mei-Hua Zheng, Qian Liu, Xiang-Ting Meng, Tao Pan, Zhen-Yuan Li, Ruo-Xuan Peng, Ke Liu, Hua-Ying Fan   +10 more
doaj   +1 more source