Results 21 to 30 of about 4,361 (182)

Genotoxicity and acute and subchronic toxicity studies of a bioactive polyoxometalate in Wistar rats

BMC Pharmacology and Toxicology, 2017
Background Cs2K4Na [SiW9Nb3O40] (POM93) is a novel broad-spectrum antiviral agent with high activity, high stability, and low toxicity in vitro. Most toxicity studies for POM93 have been performed in cultured cell lines rather than in animals. Like other
Xiaofeng Qu, Kun Xu, Chao Zhao, Xiuling Song, Jinhua Li, Li Li, Wei Nie, Hao Bao, Juan Wang, Fenglan Niu, Juan Li   +10 more
doaj   +1 more source

Toxicity Profiles of Kleeb Bua Daeng Formula, a Traditional Thai Medicine, and Its Protective Effects on Memory Impairment in Animals

Pharmaceuticals, 2022
Kleeb Bua Daeng (KBD) formula has long been used in Thailand as a traditional herbal medicine for promoting brain health. Our recent reports illustrated that KBD demonstrates multiple modes of action against several targets in the pathological cascade of
Pornthip Waiwut, Kanchana Kengkoom, Wanassanun Pannangrong, Natdanai Musigavong, Chantha Chheng, Kusawadee Plekratoke, Pitchayakarn Taklomthong, Nutchareeporn Nillert, Supaporn Pitiporn, Pakakrong Kwankhao, Supawadee Daodee, Yaowared Chulikhit, Orawan Montakantirat, Chantana Boonyarat   +13 more
doaj   +1 more source

Toxicological Assessments of a Proprietary Blend of Punica granatum Fruit Rind and Theobroma cacao Seed Extracts: Acute, Subchronic, and Genetic Toxicity Studies

Journal of Toxicology, 2022
LN18178 (Tesnor®) is a standardized, proprietary composition of aqueous ethanol extracts of Punica granatum fruit rind and Theobroma cacao seeds. The present study demonstrates a broad-spectrum toxicological evaluation of LN18178 utilizing in vitro and ...
Ravi Kumar Madireddy, Krishnaraju Venkata Alluri, Venkateswarlu Somepalli, Trimurtulu Golakoti, Krishanu Sengupta   +4 more
doaj   +1 more source

Current Approaches to the Preclinical Assessment of Endocrine Toxicity

Безопасность и риск фармакотерапии, 2023
Scientific relevance. Endocrine disruptors affect the functioning of endocrine organs, which leads to adverse drug reactions. Endocrine toxicity requires special attention in preclinical studies of candidate medicinal products.Aim.
D. A. Babkov
doaj   +1 more source

Safety evaluation of ethanol extract from Artocarpus altilis leaves as a herbal medicine candidate: Studies in acute and subchronic toxicity

Phytomedicine Plus
Background: Artocarpus altilis is a traditional medicine proven to be efficacious in several pharmacological tests using animal models. However, there have been no reports regarding its safety so far.
Fitrya Fitrya, Elfita Elfita, Ferlinahayati, Salma Fayzah Septami, Umi Tsalsa Sabrina, Fatma Sri Wahyuni, Annisa Amriani, Rennie Puspa Novita   +7 more
doaj   +1 more source

Safety Evaluation and Whole Genome Sequencing of Aspergillus japonicas PJ01 Reveal Its Potential to Degrade Citrus Segments in Juice Processing

Foods, 2021
Aspergillus japonicas PJ01 (A. japonicas PJ01) is a strain isolated from the rotten branches. In previ-ous studies, it was shown that it can produce complex enzymes to degrade polysaccharide com-ponents.
Yujiao Qian, Zhipeng Gao, Jieyi Wang, Chen Wang, Gaoyang Li, Fuhua Fu, Jiajing Guo, Yang Shan   +7 more
doaj   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

UJI TOKSISITAS SUBKRONIS INFUSA DAUN SIRIH MERAH (Piper crocatum Ruiz & Pav) PADA TIKUS: STUDI TERHADAP GAMBARAN MIKROSKOPIS JANTUNG DAN KADAR SGOT DARAH

Jurnal Farmasi Sains dan Komunitas, 2016
: Red betel (Piper crocatum Ruiz & Pav) is one of the plants used as traditional medicine community. To determine the level of safety of long-term consumption, then tested subchronic toxicity.
Ignasius Kuncarli, Ipang Djunarko
doaj   +1 more source

Nanoparticle‐Mediated TIPE1 mRNA Delivery Enhances Paclitaxel Sensitivity in Triple‐Negative Breast Cancer by Modulating RAB7A Ubiquitination‐Associated Stability and Autophagy

Advanced Science, EarlyView.
TIPE1m NPs nanoparticles restore TIPE1 expression, promote RAB7A ubiquitination and degradation, suppress autophagic flux, and resensitize paclitaxel‐resistant triple‐negative breast cancer to therapy. ABSTRACT Acquired paclitaxel (PTX) resistance remains a major obstacle in triple‐negative breast cancer (TNBC) treatment.
Wei Hu, Qishuai Chen, Yan Ma, Yang Liu, Xianing Dong, Wenjuan Wei, Jianxin Du, Shusheng Qiu, Maojin Tian, Peiqing Zhao   +9 more
wiley   +1 more source

CDK4/MERCs/PINK1 Axis Drives PFOA/HFPO‐TA‐Induced Cardiac Senescence via Mitophagy Defect and cGAS‐STING Activation: In Vitro Amelioration by Cycloastragenol

Advanced Science, EarlyView.
The present study demonstrated that PFOA and HFPO‐TA exposure suppressed CDK4, disrupted MERCs and impaired PINK1/Parkin‐mediated mitophagy, thereby accelerating cardiac senescence, whereas CAG effectively reversed these pathological changes in vitro. Our findings identify CDK4 as a critical regulator bridging mitophagy defects and cardiac senescence ...
Nuo‐Wa Li, Jun‐Ze Jiang, Ying‐Ying Liu, Tian‐Tian Zhang, Kanwar Kumar Malhi, Xin Yao, Jin‐Long Li   +6 more
wiley   +1 more source