Results 1 to 10 of about 4,361 (182)

Characterizing the Antihyperglycemic Activity and Underlying Mechanisms of the Aqueous Extract of the Leaves from Ficus carica L. [PDF]

Molecules
Ficus carica L. is traditionally used for diabetes management. This study evaluated the antihyperglycemic activity, safety, possible mechanisms, and phytochemical composition of its aqueous leaf extract (EAcFc).
Fernando Calzada, Jesica Ramírez-Santos, Hannia Pérez-Álvarez, Miguel Valdes, Elizabeth Barbosa, Claudia Velázquez   +5 more
doaj   +2 more sources

A comprehensive safety evaluation of approved 2′-fucosyllactose for human nutritional applications in China [PDF]

Frontiers in Toxicology
Background2′-Fucosyllactose (2′-FL), as a significant human milk oligosaccharide, plays a crucial role in infant formula products. This study aims to provide a scientific basis for the safe application of 2′-FL by systematically evaluating its ...
Jiangge Zheng, Huali Wang, Wenfeng Liu, Zhongzhou Chen, Jiyue Zhang, Jianbo Zhang   +5 more
doaj   +2 more sources

Stevia rebaudiana extract (main components: chlorogenic acid and its analogues) as a new safe feed additive: evaluation of acute toxicity, sub chronic toxicity, genotoxicity, and teratogenicity [PDF]

Frontiers in Veterinary Science
IntroductionStevia rebaudiana extract (SREC), primarily composed of chlorogenic acid and its analogues, is a promising feed additive with potential benefits for livestock performance, gut health, and antioxidant capacity.
Yuting Li, Liping Zhu, Dongsheng He, Ling Fang, Yajing Li, Shusheng Tang   +5 more
doaj   +2 more sources

Safety Evaluation of the Aqueous Extract of the Mixture of Persea americana (Lauraceae), Cymbopogon citratus (Poaceae), Fruits of Citrus medica (Rutaceae), and Honey in Wistar Rat [PDF]

Journal of Toxicology
As part of the valorization of traditional medicine drugs, toxicological studies were carried out on the mixture of the aqueous extract of Persea americana, Cymbopogon citratus, Citrus medica, and honey, a traditional mixture recognized for its ...
Malane Nsangou Aicha El Ramadan, Bilanda Danielle Claude, Thamadeu Marie-Claire, Bidingha à Goufani Ronald, Tcheutchoua Yannick Carlos, Owona Pascal Emmanuel, Ngapout Fifen Rodrigue, Mbolang Nguegang Loick, Djientcheu Deugoue Franck Yvan, Dzeufiet Djomeni Paul Désiré, Kamtchouing Pierre   +10 more
doaj   +2 more sources

Repeated Systemic Toxicity Tests: A Call for Proper Understanding of Tests Durations Nomenclature [PDF]

Asia Pacific Journal of Medical Toxicology, 2022
Background: Testing of substances such as drugs, food, cosmetics, and chemicals meant for human utilization requires necessary guidelines to be followed.
Earnest Erhirhie, Goodies Moke
doaj   +1 more source

Safety evaluation of extracellular vesicles derived from hypoxia primed mesenchymal stem cells of umbilical cord and adipose tissue [PDF]

Scientific Reports
Extracellular vesicles (EVs) hold great promise as regenerative therapeutics due to their roles in intercellular communication and tissue repair. This study aimed to assess the safety of EVs derived from human mesenchymal stem cells (MSCs) obtained from ...
Quyen Thi Nguyen, Nhung Thi Hong Dinh, Ngo Thu Hang, Can Van Mao, Xuan-Hai Do, Duc Son Le, Hong-Nhung Dao, T. Ngan Giang, Nicholas Forsyth, Van T. Hoang, Liem Nguyen Thanh   +10 more
doaj   +2 more sources

Acute and Subchronic Oral Toxicity Evaluation of Herbal Formulation: Piper crocatum Ruiz and Pav., Typhonium flagelliforme (Lodd.) Blume, and Phyllanthus niruri L. in Sprague–Dawley Rats

Journal of Toxicology, 2023
Background. The product combination of Piper crocatum Ruiz. and Pav., Phyllanthus niruri Linn., and Typhonium flagelliforme (Lodd.) BL ethanolic extract (SKM) exerts immunomodulatory activity.
Retno Murwanti, A. Nurrochmad, Andayana P. Gani, Ediati Sasmito, Angela E. Edwina, Mayang K. Chandra, F. H. Suryawan, A. R. Wardana, null Natalia, Jelita L. S. R. Budiningsih   +9 more
doaj   +1 more source

Evaluation of acute, subacute, and subchronic toxicity of a hepatoprotective herbal formulation

Toxicology Reports, 2023
Background: The possible toxicity of natural products must be tested before being used in the market. The present work aimed to evaluate acute, subacute, and subchronic toxicity of an herbal formulation containing Anethum graveolens, Cynara scolymus ...
Abolfazl Bemidinezhad, Seyyed Abbas Zojaji, Shirin Taraz Jamshidi, Mostafa Mohammadi, Mohaddeseh Sadat Alavi, Ahmad Ghorbani   +5 more
doaj   +1 more source

Acute and Subchronic Toxicity of Indonesian House Dust Mites (IHDM) Allergenic Extract for Asthma Allergy Immunotherapy

Jurnal Farmasi dan Ilmu Kefarmasian Indonesia, 2022
Background: In developing a pharmaceutical product, it is necessary to conduct pre-clinical and clinical trials to ensure its safety and effectiveness.
Aniek Setiya Budiatin, Yusuf Alif Pratama, Winda Fatma Sari, Mahardian Rahmadi, Muhammad Taher, Zainul Amiruddin Zakaria, Junaidi Khotib   +6 more
doaj   +1 more source

Toxicological evaluation of lactase derived from recombinant Pichia pastoris. [PDF]

PLoS ONE, 2014
A recombinant lactase was expressed in Pichia pastoris, resulting in enzymatic activity of 3600 U/mL in a 5 L fermenter. The lactase product was subjected to a series of toxicological tests to determine its safety for use as an enzyme preparation in the ...
Shiying Zou, Xiaoyun He, Yifei Liu, Delong Chen, Yunbo Luo, Kunlun Huang, Wei Zhang, Wentao Xu   +7 more
doaj   +1 more source