Results 51 to 60 of about 3,927 (153)

Subchronic toxicity test on combination of extracted Phyllanthus niruri and Centella asiatica on haematology in rats [PDF]

Jurnal Kedokteran dan Kesehatan Indonesia, 2019
Background: Meniran (Phyllathus niruri) and Pegagan (Centella asiatica) are well-known medicinal plants in Indonesia. Uses of Meniran and Pegagan as herbal medicines need to be examined for their subchronic activity to assure their safety. Objective: This study aimed to evaluate subchronic effects of a combination of extracted Meniran and Pegagan on ...
Fatmawati Fatimah, Siti, Darmawan, Endang, Narwanti, Iin, Dzulhaifa, Dzulhaifa, Aprilia Wulandari, Ira, Putri Salma, Ria   +5 more
openaire   +3 more sources

Emex spinosa (L.) Campd.: A Review on Ethnomedicinal, Phytochemical, Pharmacological, and Toxicological Profile

Chemistry &Biodiversity, Volume 23, Issue 3, March 2026.
Graphical abstract illustrating the pharmacological potential of E. spinosa. ABSTRACT Emex spinosa (L.) Campd. (E. spinosa) is a plant species belonging to the Polygonaceae family. It is native to the Middle East, North Africa, and Europe and is most commonly seen on the coastlines of Mediterranean countries.
Smail Amtaghri, Kolawole Olofinsan, Mitchel Otieno Okumu, Kopang Clemendi Mokhetho, Shabnoor Iqbal, Innocensia M. Mangoato, Mohamed Amtaghri, Mouloud Lamtai, Mohamed Yassine El Brouzi, Motlalepula G. Matsabisa   +9 more
wiley   +1 more source

Safety Assessment and the Potential of a Postbiotic Powder Formulated from a Three-Strain Fermentation of Lactobacillus salivarius AP-32, Lactobacillus paracasei ET-66, and Lactobacillus plantarum LPL28

Fermentation
This study evaluated the safety, antimicrobial activity, and upper gastrointestinal gastroprotection of a postbiotic powder derived from Lactobacillus salivarius AP-32, Lactobacillus paracasei ET-66, and Lactobacillus plantarum LPL28.
Ching-Min Li, Yen-Yu Huang, Chi-Huei Lin, Jia-Hung Lin, Yi-Wei Kuo, Ko-Chiang Hsia, Shin-Yu Tsai, Yu-Fen Huang, Ching-Wei Chen, Hsieh-Hsun Ho   +9 more
doaj   +1 more source

Anti-inflammatory and toxicity studies of atranorin extracted from Cladina kalbii Ahti in rodents

Brazilian Journal of Pharmaceutical Sciences, 2011
Atranorin (ATR) is the main compound from the lichen Cladina kalbii Ahti, which grows in the arid regions of northeastern Brazil. This study was conducted to evaluate the anti-inflammatory and toxicological properties of ATR.
Marcelia Garcez Dória de Melo, Adriano Antunes de Souza Araújo, Mairim Russo Serafini, Larissa Feitosa Carvalho, Marília Santos Bezerra, Cledison Santos Ramos, Leonardo Rigoldi Bonjardim, Ricardo Luiz Cavalcanti Albuquerque-Júnior, Julianeli Tolentino Lima, Rosana Souza Siqueira, Vanessa Silveira Fortes, Maria José Vieira Fonseca, Lucindo José Quintans-Júnior   +12 more
doaj   +1 more source

Insect‐Derived Bioactives for Glycemic Control and Gut Health: A Review

Food Frontiers, Volume 7, Issue 2, March 2026.
Insect‐derived bioactive compounds (e.g., peptides, polysaccharides) effectively regulate blood glucose through dual mechanisms: directly inhibiting carbohydrate‐digesting enzymes and glucose transporters, and indirectly modulating gut microbiota to enhance intestinal barrier integrity.
Chaoyi Lv, Yuanyuan Huang, Mokhtar Dabbour, Benjamin Kumah Mintah, Ronghai He, Haile Ma   +5 more
wiley   +1 more source

Toxicological evaluation of porcine bile powder in Kunming mice and Sprague–Dawley rats

Frontiers in Pharmacology
Background: Porcine bile powder (PBP) is a traditional Chinese medicine that has been used for centuries in various therapeutic applications. However, PBP has not previously undergone comprehensive component analysis and not been evaluated for safety ...
Lirong Wu, Jieyi Wang, Jing Lei, Kun Ge, Chun Qu, Jiajian Liu, Fengjie Huang, Dongnan Sun, Xiaowen Chao, Tianlu Chen, Aihua Zhao, Wei Jia, Wei Jia, Xiaojiao Zheng, Guoxiang Xie   +14 more
doaj   +1 more source

Ximenia americana L. From Popular Use to Anti‐Inflammatory Activities: A Comprehensive Review

Food Frontiers, Volume 7, Issue 2, March 2026.
ABSTRACT Ximenia americana (L.), known as “yellow plum,” “sea lemon,” or “Brazilian plum,” is a tropical/subtropical plant widely used in traditional medicine. Its roots, leaves, flowers, stem, and fruits are traditionally employed to treat various inflammatory disorders.
Bruno Anderson F. Silva, Maria Gabriely de Lima Silva, Eduardo S. Silva, Lucas Yure S. Silva, Renata Torres Pessoa, Silvio C. Alves‐Júnior, Jullyana S. S. Quintans, Laurent Picot, Irwin Rose A. Menezes, Lucindo J. Quintans‐Júnior   +9 more
wiley   +1 more source

Study on the Potential Molecular Mechanisms of Sodium Dehydroacetate (Na‐DHA) Interfering With Bone Metabolism and Inducing Osteoporosis Based on Network Toxicology, Molecular Docking, and In Vitro Experimental Validation

Food Science &Nutrition, Volume 14, Issue 3, March 2026.
The main workflow and core design concept of the current study. ABSTRACT Sodium Dehydroacetate (Na‐DHA), a widely used food additive, has raised concerns about the chronic health risks associated with long‐term exposure. However, the potential impact of Na‐DHA on bone metabolism, its contribution to osteoporosis risk, and the specific molecular ...
Weihong Qian, Qingqing Bao, Xiaoqing Tang, Wuchao Lu, Jiaxin Huang, Jiapeng Bao, Zhihong Yao   +6 more
wiley   +1 more source

Acute and Subchronic Toxicity Assessment of Aerial Parts of Ferula persica in Female Mice

Journal of Medicinal Plants, 2019
Background: Ferula species have shown wide range of pharmacological properties but there is no study on oral safety profile of Ferula persica due to standard toxicology guidelines.
M Soleimani Far, F Mojab, S Arbabi Bidgoli   +2 more
doaj  

Pre-clinical safety studies of intranasal virus-like particles based vaccine for prevention of COVID-19

Вопросы вирусологии
Introduction. The large-scale and prolonged pandemic of the novel coronavirus disease (COVID-19) has demonstrated the need for effective vaccination. Along with immunogenicity, safety is a critical issue for vaccines, as public trust can contribute to ...
Yana Y. Chernoryzh, Valeria M. Kondratieva, Аnastasia P. Malkova, Tatyana E. Savochkina, Olesya V. Eliseeva, Oleg E. Latyshev, Dmitriy Y. Yakunin, Olga N. Zaykova, Ekaterina S. Sludnyakova, Tatyana V. Grebennikova   +9 more
doaj   +1 more source