Results 121 to 130 of about 784,142 (261)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Caracterização físico-química de ossos liofilizados de origem bovina e humana

Revista do Colégio Brasileiro de Cirurgiões
OBJETIVO: Verificar as similaridades físico-químicas por meio de análises orgânicas e minerais de ossos liofilizados humanos e bovinos produzidos a partir de um protocolo de processamento desenvolvido pelos autores.
Carlos Roberto Galia, Carlos Alberto de Souza Macedo, Ricardo Rosito, Tielle Muller de Mello, Cristiano Diesel, Luis Fernando Moreira   +5 more
doaj   +1 more source

Immunotoxicity In Vitro Assays for Environmental Pollutants under Paradigm Shift in Toxicity Tests. [PDF]

Int J Environ Res Public Health, 2022
Wang X, Li N, Ma M, Han Y, Rao K.
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Review of DDT, DDE, DDD, DDMU and DDMS Toxicity Data for Organisms Used in Estuarine and Marine Sediment Toxicity Tests. [PDF]

Bull Environ Contam Toxicol, 2023
Burkhard LP, Elonen GE, Mount DR.
europepmc   +1 more source

Repellent, irritant and toxic effects of plant EO compounds on the malaria vector Anopheles gambiae ss Giles [PDF]

, 2013
yrethroids resistance has become widespread among malaria vector Anopheles gambiae populations in Africa. Alternative insecticides must be considered to prevent diseases transmission by An. gambiae bites. The long lasted treated bed nets are particularly
Dumenil, Claire
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Comparação de métodos para testar a citotoxicidade "in vitro" de materiais biocompatíveis

Revista de Saúde Pública
OBJETIVO: Comparar a sensibilidade do método de difusão em ágar e do método de extração utilizando as linhagens celulares RC-IAL (células fibroblásticas de rim de coelho) e HeLa (células epiteliais de carcinoma do colo do útero humano), na avaliação da ...
Aurea Silveira Cruz, Cristina Adelaide Figueiredo, Tamiko Ichikawa Ikeda, Ana Claudia Egydio Vasconcelos, Jakson Batista Cardoso, Luís Florêncio de Salles-Gomes   +5 more
doaj  

Safety of the Oral Triphala Recipe from Acute and Chronic Toxicity Tests in Sprague-Dawley Rats. [PDF]

Toxics, 2022
Arpornchayanon W, Subhawa S, Jaijoy K, Lertprasertsuk N, Soonthornchareonnon N, Sireeratawong S.   +5 more
europepmc   +1 more source