Results 111 to 120 of about 410,071 (262)
Spatiotemporal Distribution of Hydrophobic Organic Contaminants in Spiked-Sediment Toxicity Tests: Measuring Total and Freely Dissolved Concentrations in Porewater and Overlying Water. [PDF]
Environ Toxicol Chem, 2021 Hiki K +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Ecotoxicological assessment of four pharmaceuticals compounds through acute toxicity tests
O Mundo da Saúde, 2014 In this study, we evaluated acute toxicity of four different pharmaceutical compounds: 17 α-ethinylestradiol (EE2), fluoxetine, diclofenac and ibuprofen to Daphnia similis. The average values of EC50 were 1.63 mg/L to the 17α-ethinylestradiol (EE2), 4.41
Flávia Junqueira de Castro +6 more
doaj
Comparison of <i>in vitro</i> (fish cell line) and <i>in vivo</i> (fish and crustacean) acute toxicity tests in aquatic toxicology. [PDF]
Vet Med (Praha), 2021 Kolarova J, Velisek J, Svobodova Z.
europepmc +1 more source
Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
Efficiency of ant-control agents in colony-level oral toxicity tests using Tetramorium tsushimae (Hymenoptera: Formicidae) for post-establishment control of the red imported fire ant, Solenopsis invicta (Hymenoptera: Formicidae). [PDF]
Appl Entomol Zool, 2023 Sakamoto H, Goka K.
europepmc +1 more source
FEBS Open Bio, EarlyView.This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake +4 more
wiley +1 more source