Results 101 to 110 of about 784,142 (261)
Journal of Tropical Pharmacy and ChemistryPyrazoline is an alkaloid compound which has various biological activities such as antibacterial, antifungal, antitumor and anticancer. The compound N-carbotioamide-3-(2,4-dichlorophenyl)-5-(4-hydroxy-3-methoxyphenyl)pyrazoline was successfully ...
Muhammad Irfan +3 more
doaj +1 more source
Rapid toxicity detection in water quality control utilizing automated multispecies biomonitoring for permanent space stations [PDF]
The objective of this study was to evaluate proposed design characteristics and applications of automated biomonitoring devices for real-time toxicity detection in water quality control on-board permanent space stations.
Eagleson, K. W. +3 more
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2022 Background and Aim The high use of pesticides has increased the concern about its possible harm to individual and environment health. Chronic exposure to pesticides has serious effects on different body organs even before the onset of clinical symptoms ...
Mir Saeed Attarchi +7 more
doaj
Potential toxicity of Schisandra chinensis to water environment: acute toxicity tests with water crustaceans. [PDF]
Environ Sci Pollut Res Int, 2023 Valíčková J +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Inhibitory Effects of Two Kinds of Microplastics on the Growth of Skeletonema costatum
Haiyang Kaifa yu guanliAs a new pollutant, microplastics may have an impact on the growth and photosynthesis of marine phytoplankton. In order to study the growth inhibitory effect of microplastics on the Skeletonema costatum in marine phytoplankton, the paper adopts light ...
YU Mingru, GUO Hui, WU Jianping
doaj
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Scientia Marina, 2004 The sediment formed by the tailings of an abandoned mine, which discharged into Portmán Bay, Murcia, SE-Spain, was tested to establish a possible gradient of heavy metals.
A. Cesar +3 more
doaj +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source