Results 91 to 100 of about 9,004 (219)

Finding Synergies for 3Rs – Toxicokinetics and Read-Across: Report from an EPAA Partners’ Forum

, 2018
The European Partnership for Alternative Approaches to Animal Testing (EPAA) convened a Partners’ Forum Toxicokinetics and Read-Across to provide an overview on research activities to develop in vitro toxicokinetics methods and physiologically-based ...
VAN AERTS Leon, TAALMAN Rob, MONSHOUWER Mario, DE GAETANO Federica, ROWAN Tim G, LAROCHE Charles, BIRK Barbara, SAUER Ursula G., BENDER Hans, DAL NEGRO Gianni, STIRLING Catrina, SCHUTTE Katrin, WEISSENHORN Renate, LOSTIA Alfonso, PAINI Alicia, JOHN David, HUBESCH Bruno, GARDNER Iain, DESAINTES Christian, IRIZAR Amaia, MUELLER Boris, KUMAR Vikas, AGGARWAL Manoj, REID Kirsty, CROZIER Jonathan, BENNDORF Paul, SACHANA Magda, MANOU Irene   +27 more
core   +1 more source

Buthanol toxicokinetics in mice

, 2009
Широкое использование бутанола в промышленности значительно повышает риск отравления им. Поскольку эффективная терапия отравлений возможна только с учетом особенностей токсикокинетики вещества, целью работы было изучение токсикокинетических показателей ...
Овчаренко, Н.В., Головенко, М.Я., Ларіонов, В.Б., Цапенко, Ж.М.   +3 more
core   +1 more source

Toxicokinetics of sulfur mustard

, 2016
In this chapter an overview is presented on the state of knowledge concerning the toxicokinetics of sulfur mustard. The procedures to analyze intact sulfur mustard in the blood and tissues of laboratory animals at toxicologically relevant levels are ...
Noort, D., Langenberg, J.P., Schans, M.J. van der   +2 more
core  

Environmental chemicals as substrates, inhibitors or inducers of drug transporters: implication for toxicokinetics, toxicity and pharmacokinetics.

, 2012
International audienceINTRODUCTION: Membrane drug transporters are well recognized as important contributing factors to pharmacokinetics, notably involved in drug-drug interactions.
Le Vee, Marc, Kolasa, Elise, Fardel, Olivier   +2 more
core   +1 more source

Benzo[b]fluoranthene Induces Mutation Accumulation and Cancer‐Relevant Mutational Signatures in Mouse Lung Alongside Steady State Levels of Chromosome Damage in Blood

Environmental and Molecular Mutagenesis, Volume 67, Issue 5-7, June‐August 2026.
ABSTRACT Polycyclic aromatic hydrocarbons (PAHs) are well‐known for their mutagenic and carcinogenic effects. Benzo[b]fluoranthene (BbF) is one of 16 PAHs prioritized by the US Environmental Protection Agency for toxicological evaluation due to pervasive human exposure.
Xinwen Zhang, Cheryl A. Hobbs, Miriam V. Rivas, Alex Diesing, Danielle P. M. LeBlanc, Gu Zhou, Julie F. Foley, Paul A. White, Francesco Marchetti, Carole L. Yauk, Stephanie L. Smith‐Roe   +10 more
wiley   +1 more source

Spatial Detection of Microsphere Polystyrene Plastics and Molecular Remodeling within a Full‐Body Mouse with MALDI Trapped Ion Mobility Mass Spectrometry Imaging

Angewandte Chemie, Volume 138, Issue 22, 25 May 2026.
Orally administered polystyrene microplastics accumulate in murine tissues and are detected using MALDI‐MSI with TIMS. Lipid profiling reveals decreases in hexosylceramides, sphingomyelins, and ether‐linked phospholipids, indicating altered metabolism.
Karina A. Vargas, Amy L. Parkhurst, Ming‐Fo Hsu, Christopher Hou, Fawaz G. Haj, Elizabeth K. Neumann   +5 more
wiley   +2 more sources

Importance of Toxicokinetics to Assess the Utility of Zebrafish Larvae as Model for Psychoactive Drug Screening Using Meta-Chlorophenylpiperazine (mCPP) as Example

Frontiers in Pharmacology, 2018
The number of new psychoactive substances (NPS) increases rapidly, harming society and fuelling the need for alternative testing strategies. These should allow the ever-increasing number of drugs to be tested more effectively for their toxicity and ...
Krishna Tulasi Kirla, Krishna Tulasi Kirla, Ksenia J. Groh, Ksenia J. Groh, Michael Poetzsch, Rakesh Kumar Banote, Julita Stadnicka-Michalak, Julita Stadnicka-Michalak, Rik I. L. Eggen, Rik I. L. Eggen, Kristin Schirmer, Kristin Schirmer, Kristin Schirmer, Thomas Kraemer   +13 more
doaj   +1 more source

Environmental Exposure to Emerging Per‐ and Polyfluoroalkyl Substances and Cardiovascular Diseases: A Mixture Analysis

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background Per‐ and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants with potential cardiovascular effects. However, evidence on their combined (mixture) impact remains limited. Objectives To assess associations between individual and mixed PFAS exposures and cardiovascular disease (CVD) outcomes among US adults ...
Rezaul Karim Ripon, Md. Mahadi Hassan, Mayra Volquez, Srikanth Sola, Sujata Saunik, Satish Govind, Narayana Prasad   +6 more
wiley   +1 more source

Chronic Low‐Dose Unsymmetrical Dimethylhydrazine Exposure in Rats: Multiorgan Mechanisms and Biomarker Identification

Journal of Applied Toxicology, Volume 46, Issue 6, Page 1987-2002, June 2026.
ABSTRACT Unsymmetrical dimethylhydrazine (UDMH), a highly toxic rocket propellant with known multiorgan effects, requires urgent characterization of its chronic low‐dose toxicity. Using an integrated approach including exploratory transcriptomics (n = 3/group) and metabolomic (n = 4/group) approaches in male Sprague–Dawley rats exposed to high‐dose ...
Fuzhou Liu, Bing Liu, Keli Wang, Xiaoyu Wang, Zhen Sun, Xiaojuan Pan, Zengming Zhao   +6 more
wiley   +1 more source

Ivermectin Toxicity in Humans and Animals: Clinical Spectrum, Mechanisms, and Management

Journal of Applied Toxicology, Volume 46, Issue 6, Page 1856-1870, June 2026.
ABSTRACT Ivermectin is a widely used macrocyclic lactone with established efficacy against a broad range of parasitic infections in humans and animals and a long‐standing reputation for clinical safety. However, increasing evidence indicates that ivermectin can produce clinically relevant toxicity under specific conditions, particularly involving the ...
Serkan Yilmaz, Bayram Göktaş, İlker Ateş, Mustafa Çelik   +3 more
wiley   +1 more source