Results 11 to 20 of about 817,532 (389)
Archives of Ophthalmology, 2020 Background and Purpose: The misuse and toxicity of antibiotics remain significant public health concerns, with implications extending beyond hepatotoxicity to include pancreatic injury.
Ibrahim K. Ibrahim +5 more
semanticscholar +4 more sources
The evolving role of investigative toxicology in the pharmaceutical industry
Nature reviews. Drug discovery, 2023 For decades, preclinical toxicology was essentially a descriptive discipline in which treatment-related effects were carefully reported and used as a basis to calculate safety margins for drug candidates.
F. Pognan +13 more
semanticscholar +1 more source
The Role of Cytochrome P450s in Insect Toxicology and Resistance.
Annual Review of Entomology, 2021 Insect cytochrome P450 monooxygenases (P450s) perform a variety of important physiological functions, but it is their role in the detoxification of xenobiotics, such as natural and synthetic insecticides, that is the topic of this review. Recent advances
R. Nauen +3 more
semanticscholar +1 more source
North American Congress of Clinical Toxicology (NACCT) 2022
Clinical toxicology, 2022 Background: The Coronavirus disease 2019 pandemic led to unprecedented changes to medical education as educators adapted to a world necessitating precautions and social distancing.
N. Titelbaum +3 more
semanticscholar +1 more source
Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology
Molecules, 2020 Polymeric nanoparticles (NPs) are particles within the size range from 1 to 1000 nm and can be loaded with active compounds entrapped within or surface-adsorbed onto the polymeric core. The term “nanoparticle” stands for both nanocapsules and nanospheres,
A. Zielińska +11 more
semanticscholar +1 more source
Toxicology and pharmacology of synthetic organoselenium compounds: an update
Archives of Toxicology, 2021 Here, we addressed the pharmacology and toxicology of synthetic organoselenium compounds and some naturally occurring organoselenium amino acids. The use of selenium as a tool in organic synthesis and as a pharmacological agent goes back to the middle of
C. W. Nogueira, N. V. Barbosa, J. Rocha
semanticscholar +1 more source
Nickel: Human Health and Environmental Toxicology
International Journal of Environmental Research and Public Health, 2020 Nickel is a transition element extensively distributed in the environment, air, water, and soil. It may derive from natural sources and anthropogenic activity.
G. Genchi +4 more
semanticscholar +1 more source
Use of Zebrafish in Drug Discovery Toxicology.
Chemical Research in Toxicology, 2020 Unpredicted human safety events in clinical trials for new drugs are costly in terms of human health and money. The drug discovery industry attempts to minimize those events with diligent preclinical safety testing. Current standard practices are good at
S. Cassar +9 more
semanticscholar +1 more source