Results 51 to 60 of about 817,532 (389)
Hepatotoxic metabolites in Polygoni Multiflori Radix— Comparative toxicology in mice
Frontiers in Pharmacology, 2022 Polygoni Multiflori Radix (PM) and Rhei radix et rhizoma (rhubarb) contain similar hepatocyte-toxic anthraquinones such as emodin (major free anthraquinone in PM), physcion and their glycosides.
Shixiao Wang +29 more
doaj +1 more source
A Multi-Level Analysis of World Scientific Output in Pharmacology [PDF]
, 2012 The purpose of this chapter is to analyse international research in “pharmacology, toxicology and pharmaceutics” (hereafter pharmacology) on the basis of the scientific papers listed in the Scopus multidisciplinary database.
Olmeda-Gómez, Carlos +2 more
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The Toxicology of Benzene [PDF]
Environmental Health Perspectives, 1993 Benzene is metabolized, primarily in the liver, to a series of phenolic and ring-opened products and their conjugates. The mechanism of benzene-induced aplastic anemia appears to involve the concerted action of several metabolites acting together on early stem and progenitor cells, as well as on early blast cells, such as pronormoblasts and normoblasts
Bernard D. Goldstein +2 more
openaire +3 more sources
FEBS Letters, EarlyView.Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile +8 more
wiley +1 more source
ToxCast Chemical Landscape: Paving the Road to 21st Century Toxicology.
Chemical Research in Toxicology, 2016 The U.S. Environmental Protection Agency's (EPA) ToxCast program is testing a large library of Agency-relevant chemicals using in vitro high-throughput screening (HTS) approaches to support the development of improved toxicity prediction models. Launched
A. Richard +17 more
semanticscholar +1 more source
, 2015 With the financial support of Internal Security Fund Police Programme European Commission Directorate General Home Affairs. This project has been founded with support from the European Commission. This publication reflects the views only of the authors, and European Commission cannot be held responsible for any use which may be made of the information ...
openaire +3 more sources
ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma
Molecular Oncology, EarlyView.In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee +9 more
wiley +1 more source
Environmental toxicology and chemistry (1 November 2017–31 October 2018)
Environmental Toxicology and Chemistry, 2019 Laboratory testing of sediments frequently involves manipulation by amendment with contaminants and homogenization, which changes the physicochemical structure of sediments.
S. Nedrich +6 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova +26 more
wiley +1 more source
Green Toxicology: a strategy for sustainable chemical and material development
Environmental Sciences Europe, 2017 Green Toxicology refers to the application of predictive toxicology in the sustainable development and production of new less harmful materials and chemicals, subsequently reducing waste and exposure.
Sarah E. Crawford +7 more
doaj +1 more source