Results 141 to 150 of about 295,113 (307)
Influence of Different Transposon Families on Genomic Stability of Shewanella oneidensis MR1
Microbial Biotechnology, Volume 18, Issue 7, July 2025.This study aimed for targeted genome stabilisation in Shewanella oneidensis MR1 through two approaches: complete ISSOD2 inactivation via CRISPR‐deaminase‐mediated stop codon integration, and megaplasmid size reduction (35% deletion). Analysis revealed ISSOD2 as the most active transposon family (84% activity) and identified transposition hotspots for ...
Benjamin Fritz +2 more
wiley +1 more source
Phage proteins block and trigger retron toxin/antitoxin systems
bioRxiv, 2020 Bacteria carry dozens of Toxin/Antitoxin systems (TAs) in their chromosomes. Upon growth, the antitoxin is co-expressed and neutralizes the toxin. TAs can be activated and inhibit growth, but when and how this occurs has largely remained enigmatic ...
Jacob Bobonis +7 more
semanticscholar +1 more source
Regulating Toxin-Antitoxin Expression: Controlled Detonation of Intracellular Molecular Timebombs
Toxins, 2014 Genes for toxin-antitoxin (TA) complexes are widely disseminated in bacteria, including in pathogenic and antibiotic resistant species. The toxins are liberated from association with the cognate antitoxins by certain physiological triggers to impair ...
Finbarr Hayes, Barbara Kędzierska
doaj +1 more source
Molecular processes underlying synergistic linuron mineralization in a triple-species bacterial consortium biofilm revealed by differential transcriptomics [PDF]
, 2018 The proteobacteria Variovorax sp. WDL1, Comamonas testosteroni WDL7, and Hyphomicrobium sulfonivorans WDL6 compose a triple-species consortium that synergistically degrades and grows on the phenylurea herbicide linuron.
Anders +52 more
core +2 more sources
Toxin-Antitoxin Flocculation in Tetanus
Experimental Biology and Medicine, 1936 While the flocculation-test with diphtheria-toxin and antitoxin has given fairly good results,1, 2 the method has been found unreliable when applied to toxins and respective antitoxins of tetanus,3, 4, 5 botulinus,6, 7 staphylococcus,8 and Streptococcus scarlatinœ.9, 10Bronfenbrenner and Reichert6 found that antitoxin obtained by immunizing animals ...
openaire +2 more sources
PLoS Genetics, 2012 Abortive infection, during which an infected bacterial cell commits altruistic suicide to destroy the replicating bacteriophage and protect the clonal population, can be mediated by toxin-antitoxin systems such as the Type III protein-RNA toxin-antitoxin
Tim R Blower +4 more
doaj +1 more source
Druggability of bacterial toxins-antitoxins [PDF]
, 2015 53 p.-8 fig.-3 tab.Type II (proteic) toxin-antitoxin (TA) operons are widely spread in bacteria and archaea. They are organized as operons in which, usually, the antitoxin gene precedes the cognate toxin gene.
Balsa, Dolors +2 more
core
A competence-regulated toxin-antitoxin system in Haemophilus influenzae.
PLoS ONE, 2020 Natural competence allows bacteria to respond to environmental and nutritional cues by taking up free DNA from their surroundings, thus gaining both nutrients and genetic information.
Hailey Findlay Black +6 more
doaj +1 more source
Novel Single-Cell Method for Studying Toxin-Antitoxin Systems [PDF]
, 2016 细菌的抗药性危害日益严重，毒素－抗毒素（TA）系统在细菌内的异质性表达是多药耐受性存留细胞形成的重要原因。阐明致病菌中毒素－抗毒素系统的作用机理和生理功能对研发防控致病菌的新策略和疾病诊断治疗等具有重要意义。目前，对TA系统的研究主要集中在基因水平或转录水平，而传统基于蛋白质水平的检测方法，如WesternBlot等都是对大量细菌裂解液中的毒素抗毒素蛋白进行检测，是大量细菌内毒素抗毒素蛋白表现的集权平均。对单细菌水平的毒素－抗毒素蛋白进行快速逐一分析可揭示因集权平均而被掩盖的个体差异 ...
宋毅怡
core
The DarTG toxin-antitoxin system provides phage defence by ADP-ribosylating viral DNA
Nature Microbiology, 2022 Michele LeRoux +9 more
semanticscholar +1 more source