Results 161 to 170 of about 144,728 (208)

Mechanisms of neutralization of toxSAS from toxin-antitoxin modules. [PDF]

Nat Chem Biol
Dominguez-Molina L, Kurata T, Cepauskas A, Echemendia-Blanco D, Zedek S, Talavera-Perez A, Atkinson GC, Hauryliuk V, Garcia-Pino A.   +8 more
europepmc   +1 more source

A quinolone N-oxide antibiotic selectively targets Neisseria gonorrhoeae via its toxin-antitoxin system. [PDF]

Nat Microbiol
Mix AK, Nguyen THN, Schuhmacher T, Szamosvári D, Muenzner P, Haas P, Heeb L, Wami HT, Dobrindt U, Delikkafa YÖ, Mayer TU, Böttcher T, Hauck CR.   +12 more
europepmc   +1 more source

The HicAB System: Characteristics and Biological Roles of an Underappreciated Toxin-Antitoxin System. [PDF]

Int J Mol Sci
Encina-Robles J, Pérez-Villalobos V, Bustamante P.   +2 more
europepmc   +1 more source

A noncanonical intrinsic terminator in the HicAB toxin-antitoxin operon promotes the transmission of conjugative antibiotic resistance plasmids. [PDF]

Nucleic Acids Res
Lin J, Ni S, Li B, Guo Y, Gao X, Liu Y, Yi L, Wang P, Chen R, Yao J, Wood TK, Wang X.   +11 more
europepmc   +1 more source

Conformational change as a mechanism for toxin activation in bacterial toxin-antitoxin systems. [PDF]

J Virol
Sanchez-Torres V, Hwang H-J, Wood TK.
europepmc   +1 more source

Molecular stripping underpins derepression of a toxin-antitoxin system. [PDF]

Nat Struct Mol Biol
Grabe GJ, Giorgio RT, Wieczór M, Gollan B, Sargen M, Orozco M, Hare SA, Helaine S.   +7 more
europepmc   +1 more source

Phages carry orphan antitoxin-like enzymes to neutralize the DarTG1 toxin-antitoxin defense system. [PDF]

Nat Commun
Johannesman A, Awasthi LC, Carlson N, LeRoux M.   +3 more
europepmc   +1 more source

Regulation of toxin–antitoxin systems by proteolysis [PDF]

Plasmid, 2013
Toxin-antitoxin systems are widely distributed among many bacterial species, including human pathogens. Regulation of type II TA system functions, where both components are proteins, relies on proteolysis.
Urszula Zielenkiewicz
exaly   +6 more sources

Biology and evolution of bacterial toxin–antitoxin systems

Nature Reviews Microbiology, 2022
Toxin–antitoxin systems are widespread in bacterial genomes. They are usually composed of two elements: a toxin that inhibits an essential cellular process and an antitoxin that counteracts its cognate toxin.
Nathan Fraikin, Laurence van Melderen, Frédéric Goormaghtigh   +2 more
exaly   +2 more sources

Toxin–antitoxin systems [PDF]

Mobile Genetic Elements, 2013
Toxin-antitoxin (TA) systems are small genetic elements composed of a toxin gene and its cognate antitoxin. The toxins of all known TA systems are proteins while the antitoxins are either proteins or non-coding RNAs. Based on the molecular nature of the antitoxin and its mode of interaction with the toxin the TA modules are currently grouped into five ...
Simon Josef Unterholzner, Wilfried Rozhon, Brigitte Poppenberger   +2 more
exaly   +3 more sources