Results 181 to 190 of about 25,002 (218)
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Toxins-antitoxins: diversity, evolution and function
Critical Reviews in Biochemistry and Molecular Biology, 2011Genes for toxin-antitoxin (TA) complexes are widespread in prokaryote genomes, and species frequently possess tens of plasmid and chromosomal TA loci. The complexes are categorized into three types based on genetic organization and mode of action.
Hayes, Finbarr, Van Melderen, Laurence
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Bacterial Persistence and Toxin-Antitoxin Loci
Annual Review of Microbiology, 2012Bacterial persistence is caused by the presence of rare, slowly growing bacteria among populations of rapidly growing cells. The slowly growing bacteria are tolerant of antibiotics and other environmental insults, whereas their isogenic, rapidly growing siblings are sensitive.
Gerdes K, Maisonneuve E
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FROZEN TOXIN-ANTITOXIN REACTIONS
JAMA: The Journal of the American Medical Association, 1924To the Editor: —In view of the widespread newspaper publicity that has been given to the reactions following the injection of frozentoxin-antitoxin mixture in this state, it seems desirable at this time to issue a statement giving the main facts at Concord and Bridgewater, Mass.
George W. McCoy +2 more
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Ribonucleases in bacterial toxin–antitoxin systems
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2013Toxin-antitoxin (TA) systems are widespread in bacteria and archaea and play important roles in a diverse range of cellular activities. TA systems have been broadly classified into 5 types and the targets of the toxins are diverse, but the most frequently used cellular target is mRNA.
Cook, Gregory M. +6 more
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Toxin-Antitoxin Systems in Bacteria and Archaea
Annual Review of Genetics, 2011Almost all bacteria and many archaea contain genes whose expression inhibits cell growth and may lead to cell death when overproduced, reminiscent of apoptotic genes in higher systems. The cellular targets of these toxins are quite diverse and include DNA replication, mRNA stability, protein synthesis, cell-wall biosynthesis, and ATP synthesis.
Yoshihiro Yamaguchi +2 more
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Prokaryotic toxin–antitoxin stress response loci
Nature Reviews Microbiology, 2005Although toxin-antitoxin gene cassettes were first found in plasmids, recent database mining has shown that these loci are abundant in free-living prokaryotes, including many pathogenic bacteria. For example, Mycobacterium tuberculosis has 38 chromosomal toxin-antitoxin loci, including 3 relBE and 9 mazEF loci. RelE and MazF are toxins that cleave mRNA
Gerdes, Kenn +2 more
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Journal of the American Medical Association, 1927
In October, 1925, the health department of Kansas City, in conjunction and cooperation with the school board, undertook to inaugurate a campaign for the prevention of diphtheria. Having a good understanding of conditions in the past, particularly with respect to contagious diseases here, we estimated that if we could reach 20 per cent of the total ...
John L. Lavan, E. C. Black
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In October, 1925, the health department of Kansas City, in conjunction and cooperation with the school board, undertook to inaugurate a campaign for the prevention of diphtheria. Having a good understanding of conditions in the past, particularly with respect to contagious diseases here, we estimated that if we could reach 20 per cent of the total ...
John L. Lavan, E. C. Black
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A toxin–antitoxin module as a target for antimicrobial development
Plasmid, 2010The emergence and spread of pathogenic bacteria that have become resistant to multiple antibiotics through lateral gene transfer have created the need of novel antimicrobials. Toxin-antitoxin (TA) modules, which have been implicated in plasmid maintenance and stress management, are ubiquitous among plasmids from vancomycin or methicillin resistant ...
Oscar Rey +4 more
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Archaeal Type II Toxin-Antitoxins
2012A few of the bacterial type II TA systems, primarily those involved in translational inhibition, occur widely throughout the archaeal domain. Using a bioinformatic approach, the frequency and distribution of these diverse TA loci were examined within completed genomes of 124 archaea that are distributed fairly evenly throughout the major archaeal phyla.
Shah, Shiraz Ali, Garrett, Roger Antony
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