Results 111 to 120 of about 383,704 (324)

Shifts of dominant personality and spatial pattern formation due to spatially heterogeneous pollution [PDF]

open access: yesarXiv
Personality traits, such as boldness and shyness, play a significant role in shaping the survival strategies of animals. Industrial pollution has long posed serious threats to ecosystems and is typically distributed heterogeneously. However, how animals with different personalities respond to spatially heterogeneous pollution remains largely unexplored.
arxiv  

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

Candida albicans Impacts Staphylococcus aureus Alpha-Toxin Production via Extracellular Alkalinization

open access: yesmSphere, 2019
Candida albicans and Staphylococcus aureus are common causes of nosocomial infections with severe morbidity and mortality. Murine polymicrobial intra-abdominal infection (IAI) with C. albicans and S.
Olivia A. Todd   +2 more
doaj   +1 more source

A simple mathematical model for assessment of anti-toxin antibodies [PDF]

open access: yesarXiv, 2011
The toxins associated with infectious diseases are potential targets for inhibitors which have the potential for prophylactic or therapeutic use. Many antibodies have been generated for this purpose, and the objective of this study was to develop a simple mathematical model that may be used to evaluate the potential protective effect of antibodies ...
arxiv  

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

open access: yesMolecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez   +17 more
wiley   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

open access: yesMolecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Numerical and analytical approaches to an advection-diffusion problem at small Reynolds number and large Péclet number [PDF]

open access: yesarXiv, 2016
Obtaining a detailed understanding of the physical interactions between a cell and its environment often requires information about the flow of fluid surrounding the cell. Cells must be able to effectively absorb and discard material in order to survive. Strategies for nutrient acquisition and toxin disposal, which have been evolutionarily selected for
arxiv  

Cyanobacterial Toxins

open access: yes, 2009
Lethal intoxications of animals dwelling in aquatic habitats are recurrently observed with blooms of cyanobacteria. The latter produces two types of toxins : cytotoxins & biotoxins and a few antibiotics (allelopaths) such as acutiphycins, indolcarbazoles, tantazoles, tolytoxins etc.
Garg, HK, Garg, Jaya
openaire   +1 more source

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